Linking Complex Disease and Exposure Data to Established Data Standards

将复杂疾病和暴露数据与既定数据标准联系起来

基本信息

  • 批准号:
    9766828
  • 负责人:
  • 金额:
    $ 32.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-15 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT The goals of this proposed study, “Linking Complex Disease and Exposure Data to Established Data Standards,” are to use the community-based data standard consensus measures for Phenotypes and eXposures (PhenX) to link existing studies and, through that linkage, to extend semantic standards to environmental contributors to complex diseases and conditions. Our approach will address a documented standards gap, perform a pilot analysis, increase the reusability of seminal studies, and serve as a model for future data-driven standards efforts. To accomplish this, we offer a unique cross-disciplinary team of standards developers and researchers. The proposed 3-year research plan will meet the evolving needs of the environmental and human health research communities and address the need for Big Data to Knowledge (BD2K) Community-Based Data and Metadata Standards. We propose extending the application of existing standards to identify multifaceted interactions between environmental exposures and complex diseases through the following specific aims. 1: Use PhenX measures to link variables and identify gaps within our collaborative analysis of the four seminal studies: the Gulf Resilience on Women's Health Study, Gulf Long-term Follow-up Study, Multi-Ethnic Study of Atherosclerosis, and Columbia Center for Children's Environmental Health cohort. We will (a) identify study variable linkages to the PhenX data standard, common variables among the four studies, and potential cross-cutting research questions and (b) perform a pilot cross-study analysis to demonstrate that data harmonization revealed new results. 2: Extend existing formal ontologies in exposures and complex diseases to further support variable linkage and data harmonization efforts and to begin modeling exposure-disease interactions. (a) Use identified linkages to evaluate and extend the Environmental Conditions, Treatments, and Exposures Ontology (ECTO) to include concepts relevant to environmental contributors to complex disease, such as route of exposure and health outcomes. (b) Use the complex hierarchical structure provided by the ontology to facilitate further harmonization and evaluation of mappings to standard data elements. (c) Build and make available a community-based ontology of concepts relevant to environmental exposures and complex diseases. 3: Create Logical Observation Identifiers Names and Codes (LOINC) to simplify the electronic exchange of results. LOINC, a widely adopted standard in laboratory and clinical observation systems, will facilitate the integration of identified, linked data elements into existing clinical informatics pipelines. Through these aims, the proposed work has the potential to have a dramatic impact on the scientific inquiries by advancing tools for data integration in an area of current public health concern and active research: environmental contributors to complex disease occurrences and outcomes.
项目总结/文摘

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study.
  • DOI:
    10.3389/fphar.2022.883433
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5.6
  • 作者:
    Mandal, Meisha;Levy, Josh;Ives, Cataia;Hwang, Stephen;Zhou, Yi-Hui;Motsinger-Reif, Alison;Pan, Huaqin;Huggins, Wayne;Hamilton, Carol;Wright, Fred;Edwards, Stephen
  • 通讯作者:
    Edwards, Stephen
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Carol Marie Hamilton其他文献

Carol Marie Hamilton的其他文献

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{{ truncateString('Carol Marie Hamilton', 18)}}的其他基金

Establishing the PhenX Toolkit as a Biomedical Knowledgebase
将 PhenX 工具包建立为生物医学知识库
  • 批准号:
    10807362
  • 财政年份:
    2022
  • 资助金额:
    $ 32.94万
  • 项目类别:
Establishing the PhenX Toolkit as a Biomedical Knowledgebase
将 PhenX 工具包建立为生物医学知识库
  • 批准号:
    10707376
  • 财政年份:
    2022
  • 资助金额:
    $ 32.94万
  • 项目类别:
Linking Complex Disease and Exposure Data to Established Data Standards
将复杂疾病和暴露数据与既定数据标准联系起来
  • 批准号:
    9383531
  • 财政年份:
    2017
  • 资助金额:
    $ 32.94万
  • 项目类别:
An Extendable Infrastructure for Building Broad Community Support Around Clinical Trials Measures
可扩展的基础设施,可围绕临床试验措施建立广泛的社区支持
  • 批准号:
    8870486
  • 财政年份:
    2014
  • 资助金额:
    $ 32.94万
  • 项目类别:
Genomic Resource Grant for the PhenX Toolkit - expansion and sustainabilityPhenX Supplement for COVID-19 Research
PhenX 工具包的基因组资源资助 - 扩展和可持续性PhenX 针对 COVID-19 研究的补充
  • 批准号:
    10179036
  • 财政年份:
    2013
  • 资助金额:
    $ 32.94万
  • 项目类别:
Genomic Resource Grant for PhenX Toolkit - expansion and sustainability: Resource Project
PhenX 工具包的基因组资源资助 - 扩展和可持续性:资源项目
  • 批准号:
    10161810
  • 财政年份:
    2013
  • 资助金额:
    $ 32.94万
  • 项目类别:
Genomic Resource Grant for PhenX Toolkit (U41)
PhenX 工具包基因组资源资助 (U41)
  • 批准号:
    8690935
  • 财政年份:
    2013
  • 资助金额:
    $ 32.94万
  • 项目类别:
Genomic Resource Grant for the PhenX Toolkit - expansion and sustainability
PhenX 工具包的基因组资源资助 - 扩展和可持续性
  • 批准号:
    10594857
  • 财政年份:
    2013
  • 资助金额:
    $ 32.94万
  • 项目类别:
Genomic Resource Grant for the PhenX Toolkit - expansion and sustainability
PhenX 工具包的基因组资源资助 - 扩展和可持续性
  • 批准号:
    9277874
  • 财政年份:
    2013
  • 资助金额:
    $ 32.94万
  • 项目类别:
Genomic Resource Grant for PhenX Toolkit (U41)
PhenX 工具包基因组资源资助 (U41)
  • 批准号:
    8728441
  • 财政年份:
    2013
  • 资助金额:
    $ 32.94万
  • 项目类别:

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