Establishing the PhenX Toolkit as a Biomedical Knowledgebase

将 PhenX 工具包建立为生物医学知识库

• 批准号: 10807362
• 负责人: Carol Marie Hamilton
• 金额: $ 38.49万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10807362
• 关键词: Address; Administrative Supplement; Adolescent; Adoption; Alcohol consumption; All of Us Research Program; Award; Awareness; Biological Assay; Blood; Brain; COVID-19; Catalogs; Child Health; Clinical Research; Collaborations; Collection; Common Data Element; Communities; Complex; Consensus; Data; Data Collection; Development; Disease; Enrollment; Ensure; Etiology; Funding; Funding Opportunities; Future; Genetic Diseases; Genomics; Goals; Health; Human; Individual; International; Language; Link; Logical Observation Identifiers Names and Codes; Longitudinal Studies; Measurement; Measures; Medical Marijuana; Mental Health; National Health and Nutrition Examination Survey; National Human Genome Research Institute; National Institute of Drug Abuse; Online Systems; Outcome; Parents; Participant; Patient Care; PhenX Toolkit; Phenotype; Population Assessment of Tobacco and Health; Process; Protocols documentation; Quality of life; Questionnaires; Recommendation; Recovery; Research; Research Design; Research Personnel; Research Support; Resources; Science; Source; Stigmatization; Substance Addiction; Substance Use Disorder; Substance abuse problem; Time; Tobacco; Translational Research; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Update; Work; World Health Organization; bioinformatics tool; cognitive development; data sharing; database of Genotypes and Phenotypes; electronic data; epidemiology study; genome wide association study; human disease; improved; knowledgebase; marijuana use; medical specialties; polysubstance use; repository; response; social health determinants; standard measure; substance use; translational study; volunteer; working group

PROJECT SUMMARY/ABSTRACT The goal of PhenX (consensus measures for Phenotypes and eXposures) is to provide investigators with standard measurement protocols (e.g., questionnaires, bioassays, physical measurements) to improve the quality and consistency of data collection and increase the impact of individual studies. Over time, this common currency will enable investigators to more easily combine studies to increase statistical power and compare studies to validate findings. Enabling analysis of shared data should lead to a better understanding of the etiology, progression, and treatment of human disease, ultimately leading to improvements in patient care, health outcomes, and quality of life. To this end, PhenX has established a freely available, web-based catalog of measurement protocols intended for use in genomic, clinical, translational, and epidemiological research with human participants. The PhenX Toolkit content and features are driven by the scientific community. The PhenX Steering Committee (SC) provides overarching guidance and each measurement protocol in the PhenX Toolkit is selected by a Working Group (WG) of experts using a consensus-based process that relies on input from the scientific community. The research plan will establish the PhenX Toolkit as a sustainable knowledgebase that organizes, accumulates, and annotates standard protocols and links them to relevant resources and data. Specifically, this administrative supplement will expand the Toolkit to address medical cannabis use, polysubstance use, and recovery. The specific aims of this administrative supplement are to (1) review and adjust stigmatizing language in the Substance Abuse and Additions (SAA) collections, (2) identify pertinent linkages among SAA measurement protocols and other protocols in the PhenX Toolkit, (3) address gaps in SAA coverage related to Medical Cannabis Use, Polysubstance Use, and Recovery, and (4) disseminate results to the scientific community. This effort will support NIDA-funded initiatives, raise awareness of the Toolkit as a valuable resource, and attract additional users to the Toolkit. Widespread adoption of PhenX measures will facilitate cross-study analysis, thus increasing the scientific impact of individual studies.

项目总结/摘要 PhenX的目标（表型和eXposures的共识措施）是提供调查人员 利用标准测量协议（例如，问卷调查、生物测定、物理测量），以改善 提高数据收集的质量和一致性，并增加个别研究的影响。随着时间的推移，这 共同货币将使调查人员能够更容易地联合收割机研究，以提高统计能力， 比较研究以验证发现。对共享数据的分析应该会带来更好的 了解人类疾病的病因，进展和治疗，最终导致 改善患者护理、健康结果和生活质量。为此，PhenX已经建立了一个 免费提供的，基于网络的测量协议目录，旨在用于基因组，临床， 转化和流行病学研究与人类参与者。PhenX工具包的内容和 功能是由科学界驱动的。PhenX指导委员会（SC）提供了总体 指导和PhenX工具包中的每个测量协议是由一个工作组（WG）选择的 专家们利用一个基于共识的进程，依靠科学界的投入。 该研究计划将建立PhenX工具包作为一个可持续的知识库， 收集和注释标准协议，并将它们链接到相关资源和数据。具体地说， 这份行政补充文件将扩大工具包，以解决医用大麻使用、多种物质使用 和恢复。这一行政补充规定的具体目的是：（1）审查和调整 在物质滥用和添加（SAA）集合中使用语言，（2）确定 SAA测量协议和PhenX工具包中的其他协议，（3）解决SAA覆盖范围的差距 与医用大麻使用、多物质使用和恢复有关的研究，以及（4）向 科学界。这项工作将支持NIDA资助的倡议，提高对工具包的认识， 这是一个宝贵的资源，并吸引更多的用户使用工具包。PhenX措施的广泛采用将 促进交叉研究分析，从而增加个别研究的科学影响。