Establishing the PhenX Toolkit as a Biomedical Knowledgebase

将 PhenX 工具包建立为生物医学知识库

• 批准号: 10707376
• 负责人: Carol Marie Hamilton
• 金额: $ 175万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707376
• 关键词: Address; Adoption; Area; Awareness; Bioinformatics; Biological Assay; Biomedical Research; Blood; COVID-19; Catalogs; Clinical Research; Collection; Common Data Element; Communities; Consensus; Data; Data Collection; Educational Materials; Electronic Health Record; Ensure; Etiology; Exposure to; Fast Healthcare Interoperability Resources; Focus Groups; Funding Opportunities; Genome; Genomics; Goals; Health; Health Status; Human; Individual; International; Link; Logical Observation Identifiers Names and Codes; Measurement; Measures; National Human Genome Research Institute; National Institute on Minority Health and Health Disparities; Online Systems; Outcome; Participant; Patient Care; PhenX Toolkit; Phenotype; Process; Protocols documentation; Quality of life; Questionnaires; RADx Underserved Populations; Recommendation; Research; Research Personnel; Researching COVID to Enhance Recovery; Resources; Science; Scientist; Site; Strategic vision; Substance Addiction; Substance abuse problem; Time; Translational Research; United States National Institutes of Health; United States National Library of Medicine; Update; biomedical resource; career; data sharing; database of Genotypes and Phenotypes; electronic data; epidemiology study; human disease; improved; interoperability; knowledgebase; medical specialties; outreach; response; social health determinants; working group

PROJECT SUMMARY/ABSTRACT The goal of PhenX (consensus measures for Phenotypes and eXposures) is to provide investigators with standard measurement protocols (e.g., questionnaires, bioassays, physical measurements) to improve the quality and consistency of data collection and increase the impact of individual studies. Over time, this common currency will enable investigators to more easily combine studies to increase statistical power and compare studies to validate findings. Enabling analysis of shared data should lead to a better understanding of the etiology, progression, and treatment of human disease, ultimately leading to improvements in patient care, health outcomes and quality of life. To this end, PhenX has established a freely available, Web-based catalog (https://www.phenxtoolkit.org/) of measurement protocols intended for use in genomic, clinical, translational, and epidemiological research with human participants. The PhenX Toolkit content and features are driven by the scientific community. The PhenX Steering Committee (SC) provides overarching guidance and each measurement protocol in the PhenX Toolkit is selected by a Working Group (WG) of experts using a consensus-based process that relies on input from the scientific community. Initially released in 2009, the PhenX Toolkit currently includes 874 protocols addressing human phenotypes and exposures. In the next 5 years, PhenX will expand the breadth and depth of the Toolkit, increase utility, and strive to increase awareness of the resource. The Specific Aims are to (1) review, update, and expand PhenX Toolkit content; (2) leverage biomedical standards to increase scientific impact of PhenX Toolkit; and (3) raise awareness and increase adoption of the PhenX Toolkit. This research plan will establish the PhenX Toolkit as a sustainable knowledgebase that organizes, accumulates, and annotates standard protocols and links them to relevant resources and data. This plan, which reflects a multipronged approach, will ensure that the value and impact of the PhenX Toolkit will continue to increase over time.

项目总结/文摘