Establishing the PhenX Toolkit as a Biomedical Knowledgebase

项目总结/摘要 PhenX的目标（表型和eXposures的共识措施）是为研究人员提供 标准测量协议（例如，问卷调查，生物测定，物理测量），以改善 提高数据收集的质量和一致性，并增加个别研究的影响。随着时间的推移，这 共同货币将使调查人员能够更容易地联合收割机研究，以提高统计能力， 比较研究以验证发现。对共享数据进行分析有助于更好地理解 研究人类疾病的病因、进展和治疗，最终改善患者 保健、健康结果和生活质量。为此，PhenX已经建立了一个免费的，基于Web的 用于基因组，临床， 转化和流行病学研究与人类参与者。PhenX工具包的内容和 功能是由科学界驱动的。PhenX指导委员会（SC）提供了总体 指导和PhenX工具包中的每个测量协议是由一个工作组（WG）选择的 专家们利用一个基于共识的进程，依靠科学界的投入。最初 发布于2009年，PhenX工具包目前包括874个解决人类表型的协议， 暴露。在未来5年，PhenX将扩大工具包的广度和深度，增加实用性， 努力提高对资源的认识。具体目标是（1）审查、更新和扩大 PhenX工具包内容;（2）利用生物医学标准，以增加PhenX工具包的科学影响; 和（3）提高认识和增加PhenX工具包的采用。这项研究计划将建立 PhenX工具包作为一个可持续的知识库，组织，积累，和注释标准 协议，并将其链接到相关的资源和数据。这一计划体现了多管齐下的做法， 将确保PhenX工具包的价值和影响将随着时间的推移继续增加。

PROJECT SUMMARY/ABSTRACT The goal of PhenX (consensus measures for Phenotypes and eXposures) is to provide investigators with standard measurement protocols (e.g., questionnaires, bioassays, physical measurements) to improve the quality and consistency of data collection and increase the impact of individual studies. Over time, this common currency will enable investigators to more easily combine studies to increase statistical power and compare studies to validate findings. Enabling analysis of shared data should lead to a better understanding of the etiology, progression, and treatment of human disease, ultimately leading to improvements in patient care, health outcomes and quality of life. To this end, PhenX has established a freely available, Web-based catalog (https://www.phenxtoolkit.org/) of measurement protocols intended for use in genomic, clinical, translational, and epidemiological research with human participants. The PhenX Toolkit content and features are driven by the scientific community. The PhenX Steering Committee (SC) provides overarching guidance and each measurement protocol in the PhenX Toolkit is selected by a Working Group (WG) of experts using a consensus-based process that relies on input from the scientific community. Initially released in 2009, the PhenX Toolkit currently includes 874 protocols addressing human phenotypes and exposures. In the next 5 years, PhenX will expand the breadth and depth of the Toolkit, increase utility, and strive to increase awareness of the resource. The Specific Aims are to (1) review, update, and expand PhenX Toolkit content; (2) leverage biomedical standards to increase scientific impact of PhenX Toolkit; and (3) raise awareness and increase adoption of the PhenX Toolkit. This research plan will establish the PhenX Toolkit as a sustainable knowledgebase that organizes, accumulates, and annotates standard protocols and links them to relevant resources and data. This plan, which reflects a multipronged approach, will ensure that the value and impact of the PhenX Toolkit will continue to increase over time.