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Genomic Resource Grant for PhenX Toolkit (U41)

PhenX 工具包基因组资源资助 (U41)

基本信息

批准号：
8728441
负责人：
Carol Marie Hamilton
金额：
$ 29.69万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8728441
关键词：
Address Adoption Aging Area Autistic Disorder Awareness Bioinformatics Biomedical Research Chinese People Collaborations Collection Communities Companions Consensus Data Deposition Educational workshop Ensure Exhibits Federal Government Fostering Funding Opportunities Genome Genomics Goals Grant Individual Information Systems Institutes Journals Maps Measurement Measures Metric Nature Online Systems Patient Outcomes Assessments Pediatrics Peer Review Phenotype Pilot Projects Population Process Protocols documentation Publications Rare Diseases Research Research Design Research Personnel Resources Staging Substance Addiction Substance abuse problem Translations United States National Institutes of Health Update Veterans Work base cost database of Genotypes and Phenotypes genome wide association study meetings outreach population based programs research study social standard measure symposium tool web site working group

项目摘要

"The PhenX Toolkit-Standard Measures for Genomics Research" will maintain and expand the PhenX Toolkit to meet the evolving needs of the scientific community. The Toolkit currently includes 21 research domains, and 7 collections of measures related to Substance Abuse and Addiction. The Toolkit has a broad user base, and PhenX measures are being included in ongoing studies. The goals of the proposed work are to address four new research domains, to implement a rolling review and update of the 21 research domains, to integrate Chinese and Spanish translations of Toolkit protocols, to expand into social media, to build on our collaboration with the database of Genotypes and Phenotypes (dbGaP), and to make PhenX measures visible in all completed studies deposited in dbGaP. We will also foster collaborations with related measures efforts (e.g., the Patient Reported Outcomes Measurement Information System [PROMIS] and the National Institutes of Health [NIH] Toolbox), highlighting the complementary nature of these approaches and identifying synergies. Taken together, these efforts will attract additional users to the Toolkit and raise awareness of the Toolkit as an important, helpful resource for the scientific community. Widespread adoption of PhenX measures will facilitate cross-study analysis, thus increasing the scientific impact of individual studies. With continued support, PhenX will promote and advance collaborative research across the biomedical research community.

“PhenX工具包-基因组学研究的标准措施”将维护和扩展PhenX工具包以满足科学界不断变化的需求。该工具包目前包括21个研究领域，和7个与药物滥用和成瘾有关的措施集。工具包有广泛的用户基础，和PhenX措施正在进行中的研究。拟议工作的目标是解决四个新的研究领域，对21个研究领域进行滚动审查和更新，工具包协议的中文和西班牙文翻译，以扩展到社交媒体，加强我们的合作与基因型和表型数据库（dbGaP），并使PhenX措施在所有可见已完成的研究存放在dbGaP。我们还将促进与相关措施的合作（例如，患者报告结局测量信息系统（PROMIS）和美国国立卫生研究院（NIH）卫生[NIH]研究所），强调这些方法的互补性，并确定协同作用。总之，这些努力将吸引更多的用户使用工具包，并提高人们对工具包作为一种对科学界来说是重要的有用的资源。PhenX措施的广泛采用将促进交叉研究分析，从而增加个别研究的科学影响。随着不断的支持，PhenX 将促进和推动整个生物医学研究界的合作研究。