9.4T MRI Upgrade for Translational Neuroimaging Research

9.4T MRI 升级用于转化神经影像研究

• 批准号: 10177221
• 负责人: Shella D Keilholz
• 金额: $ 90万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2023-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177221
• 关键词: Animals; Area; Brain; Communities; Computer software; Electronics; Funding; Human; Imaging Techniques; Infrastructure; Magnetic Resonance Imaging; Maintenance; Neurosciences; Noise; Operating System; Power Sources; Rattus; Research; Risk; Rodent; Signal Transduction; Time; Translational Research; Universities; Work; design; heat exchanger; imaging system; improved; magnetic field; neuroimaging; pre-clinical; pre-clinical research; repaired

Funds are requested to upgrade the existing Bruker 9.4 T small animal magnetic resonance imaging (MRI) scanner that is housed within the Center for Systems Imaging Core (CSIC) at Emory University. The software (PV5) and electronics (AVANCE-I) on the scanner are obsolete, prohibiting implementation of current imaging techniques. It is becoming difficult to obtain parts for repairs, and without an upgrade, the scanner is at risk of becoming inoperable. The proposed upgrade would use the existing magnet and Faraday cage, along with much of the existing hardware. New electronics (NEO) and the latest operating system (PV360) will be installed to bring the scanner infrastructure up to date. The other most critical pieces of the upgrade are high power shim and gradient amplifers and the addition of multiple receive channels. The 9.4T MRI system is predominantly used for neuroimaging studies in rodents, and one of the major challenges for this line of work is achieving magnetic field homogeneity. The new software and electronics allow dynamic shimming, and the replacement of existing shim and gradient power supplies with high power ones will allow the full capabilities of the RRI gradient/shim insert purchased in 2015 to be used to improve magnetic field homogeneity. Multiple receive channels will be added to allow the use of array coils, which have become ubiquitous in human neuroimaging research due to the ability to improve the signal to noise ratio and/or increase the temporal rate of acquisition. A rat brain array coil designed to work with the four receive channels will also be purchased. Other components that have needed maintenance and are at the end of their operational span are included in the upgrade, such as a heat exchanger and animal holder. The developer framework is also included to allow new sequences to be implemented on the preclinical scanner. With this upgrade, the 9.4 T MRI will remain operational so that it can continue to support preclinical research. At the same time, the new cutting-edge neuroimaging capabilities will enhance translational research by the growing neuroscience community in the Atlanta area.

需要资金升级现有的布鲁克9.4 T小动物磁共振成像（MRI） 该扫描仪位于埃默里大学系统成像核心中心（CSIC）。软件 (PV5)扫描仪上的电子设备（AVANCE-I）已过时，无法执行当前成像 技术.越来越难以获得零件进行维修，如果不升级，扫描仪将面临 变得不可操作。拟议的升级将使用现有的磁铁和法拉第笼，以及沿着的许多功能 现有的硬件。将安装新的电子设备（NEO）和最新的操作系统（PV 360）， 更新扫描仪基础设施。 升级的其他最关键的部分是高功率匀场和梯度放大器， 多个接收通道。9.4T MRI系统主要用于啮齿动物的神经成像研究， 并且这一工作线的主要挑战之一是实现磁场均匀性。新软件 和电子设备允许动态匀场，以及替换现有的匀场和梯度电源 与高功率的，将允许在2015年购买的RRI梯度/垫片插入的全部功能， 用于改善磁场均匀性。将添加多个接收通道，以允许使用阵列 线圈，由于能够改善信号， 噪声比和/或增加采集的时间速率。一种设计用于与 并会购买四个接收频道。 其他需要维护且处于运行期结束的组件包括在 升级，如热交换器和动物保持器。还包括开发人员框架， 在临床前扫描仪上实施新序列。 通过此次升级，9.4 T MRI将继续运行，以便继续支持临床前 research.与此同时，新的尖端神经成像能力将增强转化研究 亚特兰大地区不断壮大的神经科学界。