Animal Models and In Vivo Imaging Core

项目摘要-动物模型和活体成像核心 动物模型和体内成像核心将满足参与研究人员使用动物的需求 眼科疾病模型开展基础和转化性视力研究。核心将提供访问 体内生成和实施眼的先进技术和高素质的技术支持 动物模型的成像。体内综合组织偶联动物模型的可用性 结构和功能评估将极大地促进分子和细胞机制的研究 潜在的眼病过程，并促进基本科学发现的翻译，用于诊断和 治疗应用。具体目标是为以下方面提供仪器设备和技术专长：1) 生成和维护眼部疾病的动物模型，执行外科手术，获得 用于基因分型和采集眼组织的样本；2)使研究人员能够在体内使用各种眼球 成像和组织功能测试技术；3)培训调查人员和研究人员关于实用和 操作眼科成像和功能测试设备；以及4)咨询适当的 动物模型、外科手术和成像程序，以满足参与研究人员的研究需求。 。

Project Summary – Animal Models and In Vivo Imaging Core The Animal Models and In Vivo Imaging Core will meet the needs of participating investigators for using animal models of ocular diseases to conduct basic and translational vision research. The Core will provide access to advanced technologies and highly qualified technical support for generating and performing in vivo ocular imaging of animal models. The availability of animal models coupled with comprehensive in vivo tissue structure and function assessment will greatly accelerate study of molecular and cellular mechanisms underlying ocular disease processes, and facilitate translation of basic science findings for diagnostic and therapeutic applications. The specific aims are to provide instrumentation and technical expertise for: 1) generating and maintaining animal models of ocular diseases, performing surgical procedures, obtaining samples for genotyping, and harvesting ocular tissues; 2) enabling investigators to use various in vivo ocular imaging and tissue function testing technologies; 3) training investigators and research staff on the utility and operation of ocular imaging and function testing equipment; and 4) consultation regarding the appropriate animal models, surgical and imaging procedures to address research needs of participating investigators. .