Cancer Prevention and Control Research Program

癌症预防与控制研究计划

• 批准号: 10177893
• 负责人: PAUL G SPICER
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177893
• 关键词: Address; Affect; American Indians; Award; Biological Products; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Control Research Program; Caring; Catchment Area; Direct Costs; Disease Progression; Emerging Tobacco Products; Faculty; Funding; Goals; Grant; Intervention; Maintenance; Malignant Neoplasms; Nature; Oklahoma; Oncology; Patients; Peer Review; Postdoctoral Fellow; Publications; Publishing; Relapse; Reporting; Research; Research Personnel; Rural; Rural Population; Tobacco; Tobacco Use Cessation; Training; Training Programs; Training and Education; Tribes; Trust; Underserved Population; United States National Institutes of Health; Vulnerable Populations; addiction; base; cancer chemoprevention; cancer health disparity; cancer prevention; care coordination; care delivery; cohort; community based participatory research; community based research; community engaged research; graduate student; high risk; inter-institutional; member; novel; prevent; programs; tobacco prevention; underserved community

CANCER PREVENTION AND CONTROL PROGRAM – ABSTRACT The goal of the Cancer Prevention and Control (CPC) program at the Stephenson Cancer Center (SCC) is to build a robust, transdisciplinary CPC research and training program in order to reduce the burden of cancer in Oklahoma (the SCC catchment area), especially in the state's underserved populations. The program Specific Aims are: 1) to conduct community-engaged research to address the disproportionate burden of cancer affecting American Indian (AI), rural and other underserved populations in the SCC catchment area; 2) to discover the mechanisms underlying tobacco initiation, maintenance, cessation and relapse, and to develop and evaluate novel tobacco treatments targeted to vulnerable and underserved populations; and 3) to discover, develop and apply natural, synthetic and biological agents to prevent, reverse or suppress cancer disease progression in high-risk cohorts in the SCC catchment area and the nation. Highlights of the CPC program include: 1) a highly interactive team of cancer health disparities researchers who have developed collaborative, trust-based relationships with the state's AI and rural populations, leading to NIH-funded community-based research; 2) a highly successful AI Patient Navigation Program that has facilitated access for 1,554 AI patients (representing 54 different tribes) to specialized oncology care at the SCC over the past five years; 3) a growing and highly collaborative team of NIH-funded tobacco investigators who are conducting a wide range of tobacco research, from basic mechanisms of addiction to novel cessation interventions and emerging tobacco products; 4) a nationally recognized cancer chemoprevention team supported by more than $12 million in NCI funding (PREVENT and other) since 2012; and 5) a robust CPC- focused education and training program for under- and graduate students, postdoctoral fellows and junior faculty, with plans for an NIH institutional training grant submission within two years. The CPC program has 27 members, representing 11 departments and a range of transdisciplinary expertise, including cancer health disparities, community-based participatory research, care coordination and delivery, novel interventions for tobacco prevention and cessation, emerging tobacco products, basic mechanisms of addiction and cancer chemoprevention. As of December 31, 2016, CPC program members were awarded $5,575,776 (36 projects) in annual NCI and other peer-reviewed cancer-relevant funding (direct cost). NCI funding ($2,637,717) accounts for nearly half (47.3%) of the peer-reviewed funding, highlighting the program's cancer focus. Total annual CPC program funding is $8,945,333 (direct cost). For the five-year reporting period (2012-2016), CPC program members published 237 peer-reviewed articles, of which 36.3% had intra- programmatic, 5.9% had inter-programmatic, and 64.1% had inter-institutional collaborators. For 2016, intra- programmatic publications were 42.0%, underscoring the highly collaborative nature of CPC program research.

癌症预防和控制计划 - 摘要 斯蒂芬森癌症中心（SCC）预防和控制计划（CPC）计划的目标是 建立一个健壮的跨学科CPC研究和培训计划，以减少癌症的燃烧 俄克拉荷马州（SCC集水区）​​，尤其是在该州服务不足的人口中。该程序具体 目的是：1）进行社区参与的研究以解决癌症的不成比例燃烧 在SCC集水区影响美洲印第安人（AI），粗糙和其他服务不足的人群； 2）到 发现烟草倡议，维护，停止和救济的机制，并发展 并评估针对脆弱和服务不足人群的新型烟草治疗； 3）发现， 开发和应用天然，合成和生物学剂来预防，逆转或抑制癌症疾病 SCC集水区和国家的高风险人群的发展。 CPC计划的亮点包括：1）高度互动的癌症健康差异团队研究人员 他们与国家的AI和粗糙人群建立了协作，基于信任的关系，领导 进行基于NIH资助的社区研究； 2）具有非常成功的AI患者导航计划 促进了1,554名AI患者（代表54个不同部落）的访问权限 SCC在过去五年中； 3）由NIH资助的烟草调查人员组成的成长且高度协作的团队 从成瘾的基本机制到新颖的戒烟，他们正在进行广泛的烟草研究 干预和新兴的烟草产品； 4）一个全国认可的癌症化学预防团队 自2012年以来，由超过1200万美元的NCI资金（预防和其他）支持； 5）强大的CPC- 专注的教育和培训计划针对未成年人和研究生，博士后研究员和初中 教师，计划在两年内提交NIH机构培训赠款。 CPC计划有27名成员，代表11个部门和一系列跨学科专业知识， 包括癌症健康分布，基于社区的参与研究，护理协调和交付， 预防烟草预防和停止的新干预措施，新兴的烟草产品，基本机制 成瘾和癌症化学预防。截至2016年12月31日，CPC计划成员被授予 $ 5,575,776（36个项目）年度NCI和其他同行评审的与癌症相关的资金（直接成本）。 NCI 资金（$ 2,637,717）占同行评审资金的几乎一半（47.3％），重点介绍了该计划的 癌症的重点。年度CPC计划的总资金为8,945,333美元（直接费用）。五年报告期 （2012-2016），CPC计划成员发表了237篇经过同行评审的文章，其中36.3％的内部 程序化，5.9％的程序间截图，而64.1％的机构间合作者。 2016年，内部 程序化出版物为42.0％，强调了CPC计划研究的高度协作性质。