Cancer Prevention and Control Research Program

癌症预防与控制研究计划

• 批准号: 10413080
• 负责人: PAUL G SPICER
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413080
• 关键词: Address; Affect; American Indians; Award; Biological Products; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Control Research Program; Caring; Catchment Area; Direct Costs; Disease Progression; Emerging Tobacco Products; Faculty; Funding; Goals; Grant; Intervention; Maintenance; Malignant Neoplasms; Nature; Oklahoma; Oncology; Patients; Peer Review; Postdoctoral Fellow; Publications; Publishing; Relapse; Reporting; Research; Research Personnel; Rural; Rural Population; Tobacco; Tobacco Use Cessation; Training; Training Programs; Training and Education; Tribes; Trust; Underserved Population; United States National Institutes of Health; Vulnerable Populations; addiction; base; cancer chemoprevention; cancer health disparity; cancer prevention; care coordination; care delivery; cohort; community based participatory research; community based research; community engaged research; graduate student; high risk; inter-institutional; member; novel; prevent; programs; tobacco prevention; underserved community

CANCER PREVENTION AND CONTROL PROGRAM – ABSTRACT The goal of the Cancer Prevention and Control (CPC) program at the Stephenson Cancer Center (SCC) is to build a robust, transdisciplinary CPC research and training program in order to reduce the burden of cancer in Oklahoma (the SCC catchment area), especially in the state's underserved populations. The program Specific Aims are: 1) to conduct community-engaged research to address the disproportionate burden of cancer affecting American Indian (AI), rural and other underserved populations in the SCC catchment area; 2) to discover the mechanisms underlying tobacco initiation, maintenance, cessation and relapse, and to develop and evaluate novel tobacco treatments targeted to vulnerable and underserved populations; and 3) to discover, develop and apply natural, synthetic and biological agents to prevent, reverse or suppress cancer disease progression in high-risk cohorts in the SCC catchment area and the nation. Highlights of the CPC program include: 1) a highly interactive team of cancer health disparities researchers who have developed collaborative, trust-based relationships with the state's AI and rural populations, leading to NIH-funded community-based research; 2) a highly successful AI Patient Navigation Program that has facilitated access for 1,554 AI patients (representing 54 different tribes) to specialized oncology care at the SCC over the past five years; 3) a growing and highly collaborative team of NIH-funded tobacco investigators who are conducting a wide range of tobacco research, from basic mechanisms of addiction to novel cessation interventions and emerging tobacco products; 4) a nationally recognized cancer chemoprevention team supported by more than $12 million in NCI funding (PREVENT and other) since 2012; and 5) a robust CPC- focused education and training program for under- and graduate students, postdoctoral fellows and junior faculty, with plans for an NIH institutional training grant submission within two years. The CPC program has 27 members, representing 11 departments and a range of transdisciplinary expertise, including cancer health disparities, community-based participatory research, care coordination and delivery, novel interventions for tobacco prevention and cessation, emerging tobacco products, basic mechanisms of addiction and cancer chemoprevention. As of December 31, 2016, CPC program members were awarded $5,575,776 (36 projects) in annual NCI and other peer-reviewed cancer-relevant funding (direct cost). NCI funding ($2,637,717) accounts for nearly half (47.3%) of the peer-reviewed funding, highlighting the program's cancer focus. Total annual CPC program funding is $8,945,333 (direct cost). For the five-year reporting period (2012-2016), CPC program members published 237 peer-reviewed articles, of which 36.3% had intra- programmatic, 5.9% had inter-programmatic, and 64.1% had inter-institutional collaborators. For 2016, intra- programmatic publications were 42.0%, underscoring the highly collaborative nature of CPC program research.

癌症预防和控制计划 – 摘要 史蒂芬森癌症中心 (SCC) 癌症预防和控制 (CPC) 计划的目标是 建立一个强大的、跨学科的 CPC 研究和培训计划，以减轻癌症负担 俄克拉荷马州（SCC 集水区），尤其是该州服务不足的人群。方案具体 目标是：1) 开展社区参与的研究，以解决不成比例的癌症负担 影响 SCC 流域内的美洲印第安人 (AI)、农村和其他服务不足的人口； 2）到 发现烟草开始、维持、戒烟和复发的机制，并开发 评估针对弱势和服务不足人群的新型烟草治疗方法； 3）发现， 开发和应用天然、合成和生物制剂来预防、逆转或抑制癌症疾病 SCC 流域和全国高风险人群的进展。 CPC 计划的亮点包括：1) 高度互动的癌症健康差异研究人员团队 他们与该州的人工智能和农村人口建立了基于信任的合作关系，领导 NIH 资助的社区研究； 2) 一个非常成功的人工智能患者导航程序 帮助 1,554 名 AI 患者（代表 54 个不同的部落）获得专门的肿瘤护理 过去五年的SCC； 3) 由 NIH 资助的烟草调查人员组成的不断壮大且高度协作的团队 他们正在进行广泛的烟草研究，从成瘾的基本机制到新型戒烟 干预措施和新兴烟草产品； 4）国家认可的癌症化学预防团队 自 2012 年以来，获得超过 1200 万美元的 NCI 资金（预防和其他）支持； 5) 强大的 CPC- 针对本科生、研究生、博士后研究员和大三学生的重点教育和培训计划 教师，计划在两年内提交 NIH 机构培训拨款。 CPC 计划有 27 名成员，代表 11 个部门和一系列跨学科专业知识， 包括癌症健康差异、基于社区的参与性研究、护理协调和提供， 预防和戒烟的新干预措施、新兴烟草产品、烟草预防和戒烟的基本机制 成瘾和癌症化学预防。截至2016年12月31日，中共党员荣获 年度 NCI 和其他同行评审的癌症相关资金（直接费用）为 5,575,776 美元（36 个项目）。美国国家癌症研究所 资金（2,637,717 美元）占同行评审资金的近一半（47.3%），凸显了该计划的 癌症焦点。年度 CPC 计划资金总额为 8,945,333 美元（直接成本）。五年报告期 2012-2016年，CPC项目成员发表同行评审文章237篇，其中36.3%获得内部评审 程序化合作，5.9% 有程序间合作，64.1% 有机构间合作者。 2016 年，内部 计划性出版物占 42.0%，凸显了 CPC 计划研究的高度协作性质。