Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function

疼痛和感觉功能研究跨学科卓越中心

基本信息

批准号：
10176516
负责人：
IAN D MENG
金额：
$ 214.23万
依托单位：
UNIVERSITY OF NEW ENGLAND
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10176516
关键词：
Acute Acute Pain Adult Advisory Committees Affect American Animal Experimentation Antibodies Award Behavior Breeding Centers of Research Excellence Chronic Complement Consultations Contract Services Core Facility Development Development Plans Economics Environment Epidemic Extramural Activities Faculty Fellowship Fostering Funding Genotype Goals Grant Health Histology Human Resources Image Individual Institution Investments Maine Mentors Mus Neurobiology Neurosciences Neurosciences Research New England Opiate Addiction Opioid Pain Pain Research Pain management Pharmaceutical Preparations Phase Pilot Projects Positioning Attribute Principal Investigator Process Quality of life Research Research Infrastructure Research Personnel Research Project Grants Research Support Resources Sensory Series Services Students Time Transgenic Animals Transgenic Mice United States United States National Institutes of Health Universities Validation Work alternative treatment career development chronic pain economic cost equipment acquisition faculty research functional improvement in vivo innovation instrumentation member multidisciplinary novel novel therapeutics opioid epidemic pain chronification prescription opioid prevent programs rapid growth recruit research and development restoration reuptake side effect social success treatment strategy two photon microscopy

项目摘要

Treatment of chronic pain continues to rely on old drugs such as gabapentinoids, reuptake blockers and opioids, all of which have severe side effects that diminish quality of life. Tolerance develops to opioids with chronic use, and an increase in opioid prescriptions has contributed to the growing opioid addiction epidemic. There is an urgent need for finding alternative treatments for treatment of both acute chronic pain. The goal of the COBRE Phase II is to continue the development of a Center for the Study of Pain and Sensory Function that will significantly contribute to the scientific understanding of the neurobiology of acute and chronic pain, facilitating the discovery of novel therapies. Significant progress was made during Phase I: four project leaders were successful in receiving NIH support and three COBRE pilot project grants seeded studies that subsequently received extramural support. Targets for recruitment were exceeded with the addition of both senior and junior faculty members to our Center. Two research cores were established and new lab space was created through renovations. The Center will continue to build on these accomplishments, leveraging COBRE support to garner additional institutional investment in the program. Our research cores will continue to collaborate with those at other regional IDeA program funded institutions, efficiently utilizing our resources as we work towards increased sustainability. Specific Aim 1 will create a critical mass of pain researchers necessary to sustain a vibrant research center and enhance their ability to compete for extramural research support. This Aim will be accomplished by fostering the pain related research programs of four current UNE faculty members who have not received R01 or comparable Research Project Grant support. In addition, funds will be provided for pilot projects to support early stage yet innovative pain-related studies. Finally, we will recruit an additional three investigators whose research programs will complement those of the existing faculty. Specific Aim 2 will expand neuroscience research infrastructure at UNE, providing access to core facilities that allow investigators to carry out cutting edge research on the neurobiological processes involved in the development of chronic pain. This aim will be accomplished through funding key support personnel and the purchase of equipment for the two research cores established during Phase I (the Behavior Core and the Histology and Imaging Core). Expanded research core services will include mouse genotyping and expert consultations for breeding strategies required for maintaining transgenic mouse colonies (Behavior Core), and a service to validate antibodies used by COBRE center researchers (Histology and Imaging Core). With continued investment provided through Phase II funding and institutional support, we will build on our early success and clearly establish the Center as a leader in pain research.

慢性疼痛的治疗继续依赖旧药物，例如gabapentinoids，再摄取阻滞剂和阿片类药物，所有这些都具有降低生活质量的严重副作用。与阿片类药物相关的耐受性长期使用，阿片类药物处方的增加导致阿片类成瘾的流行促进。迫切需要寻找治疗急性慢性疼痛的替代治疗方法。目标 COBRE II期是继续开发疼痛和感觉功能研究中心这将大大有助于对急性和慢性疼痛神经生物学的科学理解，促进发现新疗法的发现。在第一阶段：四个项目领导者中取得了重大进展成功获得NIH支持和三个苏伯里试点项目授予了种子研究随后获得了壁外支持。添加两者都超过了招聘的目标高级和初级教师到我们中心。建立了两个研究核心和新的实验室空间是通过翻新创建的。该中心将继续以这些成就为基础，利用在该计划中获得额外的机构投资的毛cr脚支持。我们的研究核心将继续与其他区域思想计划中资助的机构合作，有效地利用我们的资源随着我们努力提高可持续性。特定的目标1将创造大量的疼痛研究人员维持充满活力的研究中心并增强其争夺外校外研究的能力所必需的必要支持。这个目标将通过培养四个当前UNE的疼痛研究计划来实现尚未获得R01或可比研究项目赠款支持的教职员工。此外，将为试点项目提供资金，以支持早期但与疼痛有关的研究。最后，我们将招募另外三名研究人员，其研究计划将补充现有的研究计划学院。特定目标2将扩大UNE的神经科学研究基础设施，从而提供核心的访问权限允许研究人员对涉及的神经生物学过程进行尖端研究的设施慢性疼痛的发展。这个目标将通过资助关键支持人员和购买在第一阶段建立的两个研究核心的设备（行为核心和组织学和成像核心）。扩展的研究核心服务将包括鼠标基因分型和专家维持转基因小鼠菌落（行为核心）所需的繁殖策略和验证cobre中心研究人员（组织学和成像核）使用的抗体的服务。和通过第二阶段资金和机构支持提供的持续投资，我们将在早期建立成功并清楚地将中心确立为疼痛研究的领导者。

项目成果

期刊论文数量（65）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States.

DOI：
10.1007/s11481-020-09936-5
发表时间：
2021-06
期刊：
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
影响因子：
0
作者：
Arabatzis TJ;Wakley AA;McLane VD;Canonico D;Cao L
通讯作者：
Cao L

Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain.