Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function

疼痛和感觉功能研究跨学科卓越中心

• 批准号: 10631127
• 负责人: IAN D MENG
• 金额: $ 106.5万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631127
• 关键词: Acute Pain; Advisory Committees; Affect; Applications Grants; Award; Behavior; Biological; Biomedical Research; Businesses; COVID-19 impact; Centers of Research Excellence; Classification; Clinical; Collaborations; Communities; Consultations; Continuing Education; Contract Services; Contracts; Core Facility; Dedications; Development; Doctor of Philosophy; Economics; Educational workshop; Engineering; Environment; Epidemic; Equipment; Extramural Activities; Faculty; Fee-for-Service Plans; Fees; Fellowship; Financial Support; Funding; Goals; Grant; Health; Histology; Human Resources; Image; Immune; Income; Individual; Industry; Institution; Intervention; Investments; Joints; Journals; Laboratories; Learning; Maine; Maintenance; Marketing; Medical Research; Mentorship; Neurons; Neurosciences; New England; New Hampshire; Opioid; Pain; Pain Research; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Phase I Clinical Trials; Pilot Projects; Population; Program Development; Program Research Project Grants; Publications; Quality of life; Research; Research Activity; Research Institute; Research Personnel; Research Project Grants; Research Support; Science; Scientific Advances and Accomplishments; Secure; Sensory; Series; Services; Severities; Signal Pathway; Signal Transduction; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Strategic Planning; Students; Sustainable Development; Time; Training; Travel; Universities; Wages; Work; addiction liability; alternative treatment; base; career development; chronic pain; chronic pain management; higher education; improved; industry partner; instrumentation; novel; opioid epidemic; pain chronification; pain relief; prescription opioid; prevent; programs; recruit; research and development; research facility; restoration; reuptake; side effect; skills; social; success; sustainable resource; voucher

Chronic pain continues to be a critical health, social and economic issue throughout the world. Patient relief is undermined by modest efficacy and/or serious, self-limiting side effects of all current pain pharmaceuticals. Moreover, the opioid epidemic, that has only increased in severity as a consequence of COVID-19, lends urgency to the search for alternative treatments for moderate to severe pain. Through Phase 1 and 2 COBRE funding and leveraged institutional support, the University of New England (UNE) Center for the Study of Pain and Sensory Function was successful in renovating new laboratory space, establishing two research core facilities, and recruiting a critical mass of investigators studying pain and its treatment. Provided with mentorship and career development support, research project funding, and access to state-of-the-art research core facilities, COBRE investigators have made major scientific advances in the discovery of novel targets for the treatment of chronic pain and secured almost $14 million in extramural research funding. The research cores have already supported SBIR and STTR projects that have led to the submission of one compound to the FDA for approval of Phase 1 clinical trials. This increase in research activity seeded by COBRE funds was largely responsible for UNE’s recent promotion to R2 status (denoted as high research activity) by the Carnegie Classification of Institutions of Higher Education. COBRE Phase 3 will build on its previous successes to secure the Center’s long-term viability. Strong institutional support will continue to be provided in the form of dedicated core space, equipment maintenance, internal funding for a research core voucher program, release time for core Directors and guarantee of core staff salary beyond Phase 3. For Aim 1, the COBRE team will continue to increase research capacity through career development programming and direct financial support for pilot research projects. The Pilot Project Program will accept applications from faculty at UNE and regional partner institutions to support projects that utilize the core facilities and have the potential to lead to extramural funding. This approach will increase the research core user base and assist in Aim 2, transitioning the research cores into sustainable resources that provide expertise, training, and state- of-the-art instrumentation to the UNE and broader scientific communities for conducting cutting-edge biomedical research. The research cores will become sustainable through collaborations with regional COBREs and Maine INBRE partners, the combined efforts of the External Advisory and Steering Committees, strong institutional support, and an aggressive business strategic planning and marketing approach. COBRE Phases 1 and 2 profoundly transformed the research environment at UNE. At the time of Phase 1 submission, core research facilities were nonexistent. The increase in research capacity created through the COBRE program has led to the recruitment and funding of a critical mass of investigators, training of a skilled workforce, and development of sustainable core research facilities that can support high-quality research for UNE faculty and students, as well as external academic and industry partners. With continued institutional investment and additional support provided through Phase 3 funding, we will build on this early success and establish our center as a leader in pain research for many years to come.

慢性疼痛仍然是全世界的关键健康，社会和经济问题。病人的救济是 由于当前所有疼痛药物的效率和/或严重的自限性副作用而受到损害。而且， opioid流行病，由于19的结果，严重程度仅增加了，因此紧迫地寻找 中度至严重疼痛的替代治疗方法。通过第1阶段和第2阶 支持，新英格兰大学（UNE）疼痛和感觉功能研究中心成功 翻新新的实验室空间，建立两个研究核心设施，并招募大量研究人员 研究疼痛及其治疗。提供有精神训练和职业发展支持，研究项目资金以及 获得最先进的研究核心设施，工行调查人员已取得了重大科学进步 发现了治疗慢性疼痛的新颖目标，并获得了近1400万美元的壁外研究 资金。研究核心已经支持SBIR和STTR项目，这些项目导致了一个 FDA的化合物批准了1期临床试验。毛cre基金播种的研究活动的增加 在很大程度上负责UNE最近晋升为Carnegie的R2状态（称为高研究活动） 高等教育机构的分类。毛bre阶段第3阶段将基于其先前的成功，以确保 中心的长期生存能力。将继续以专门的核心空间的形式继续提供强大的机构支持， 设备维护，研究核心凭证计划的内部资金，核心董事的发布时间和 保证核心员工薪水超过第3阶段。对于AIM 1，毛cre团队将继续提高研究能力 通过职业发展计划和直接对试点研究项目的财务支持。试点项目 计划将接受UNE教师和区域合作伙伴机构的申请，以支持利用该项目的项目 核心设施，并有可能导致壁外资金。这种方法将增加研究核心用户群 并协助AIM 2，将研究核心过渡到可持续资源，以提供专业知识，培训和国家 - 向UNE和更广泛的科学界进行艺术的仪器，用于进行尖端的生物医学 研究。研究核心将通过与区域Cobres和缅因州的合作而变得可持续 合作伙伴，外部咨询和指导委员会的综合努力，强大的机构支持以及 积极的业务战略计划和营销方法。毛关系1和2深刻地改变了 UNE的研究环境。在第一阶段提交时，核心研究设施不存在。增加 在通过毛绒计划创建的研究能力中，招募和资助了大量 研究人员，培训熟练的劳动力以及可以支持的可持续核心研究设施 UNE教师和学生以及外部学术和行业合作伙伴的高质量研究。继续 机构投资和通过第三阶段资金提供的额外支持，我们将基于这一早期成功和 将我们的中心作为疼痛研究的领导者，在未来的许多年中。