Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function

疼痛和感觉功能研究跨学科卓越中心

• 批准号: 10631127
• 负责人: IAN D MENG
• 金额: $ 106.5万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631127
• 关键词: Acute Pain; Advisory Committees; Affect; Applications Grants; Award; Behavior; Biological; Biomedical Research; Businesses; COVID-19 impact; Centers of Research Excellence; Classification; Clinical; Collaborations; Communities; Consultations; Continuing Education; Contract Services; Contracts; Core Facility; Dedications; Development; Doctor of Philosophy; Economics; Educational workshop; Engineering; Environment; Epidemic; Equipment; Extramural Activities; Faculty; Fee-for-Service Plans; Fees; Fellowship; Financial Support; Funding; Goals; Grant; Health; Histology; Human Resources; Image; Immune; Income; Individual; Industry; Institution; Intervention; Investments; Joints; Journals; Laboratories; Learning; Maine; Maintenance; Marketing; Medical Research; Mentorship; Neurons; Neurosciences; New England; New Hampshire; Opioid; Pain; Pain Research; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Phase I Clinical Trials; Pilot Projects; Population; Program Development; Program Research Project Grants; Publications; Quality of life; Research; Research Activity; Research Institute; Research Personnel; Research Project Grants; Research Support; Science; Scientific Advances and Accomplishments; Secure; Sensory; Series; Services; Severities; Signal Pathway; Signal Transduction; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Strategic Planning; Students; Sustainable Development; Time; Training; Travel; Universities; Wages; Work; addiction liability; alternative treatment; base; career development; chronic pain; chronic pain management; higher education; improved; industry partner; instrumentation; novel; opioid epidemic; pain chronification; pain relief; prescription opioid; prevent; programs; recruit; research and development; research facility; restoration; reuptake; side effect; skills; social; success; sustainable resource; voucher

Chronic pain continues to be a critical health, social and economic issue throughout the world. Patient relief is undermined by modest efficacy and/or serious, self-limiting side effects of all current pain pharmaceuticals. Moreover, the opioid epidemic, that has only increased in severity as a consequence of COVID-19, lends urgency to the search for alternative treatments for moderate to severe pain. Through Phase 1 and 2 COBRE funding and leveraged institutional support, the University of New England (UNE) Center for the Study of Pain and Sensory Function was successful in renovating new laboratory space, establishing two research core facilities, and recruiting a critical mass of investigators studying pain and its treatment. Provided with mentorship and career development support, research project funding, and access to state-of-the-art research core facilities, COBRE investigators have made major scientific advances in the discovery of novel targets for the treatment of chronic pain and secured almost $14 million in extramural research funding. The research cores have already supported SBIR and STTR projects that have led to the submission of one compound to the FDA for approval of Phase 1 clinical trials. This increase in research activity seeded by COBRE funds was largely responsible for UNE’s recent promotion to R2 status (denoted as high research activity) by the Carnegie Classification of Institutions of Higher Education. COBRE Phase 3 will build on its previous successes to secure the Center’s long-term viability. Strong institutional support will continue to be provided in the form of dedicated core space, equipment maintenance, internal funding for a research core voucher program, release time for core Directors and guarantee of core staff salary beyond Phase 3. For Aim 1, the COBRE team will continue to increase research capacity through career development programming and direct financial support for pilot research projects. The Pilot Project Program will accept applications from faculty at UNE and regional partner institutions to support projects that utilize the core facilities and have the potential to lead to extramural funding. This approach will increase the research core user base and assist in Aim 2, transitioning the research cores into sustainable resources that provide expertise, training, and state- of-the-art instrumentation to the UNE and broader scientific communities for conducting cutting-edge biomedical research. The research cores will become sustainable through collaborations with regional COBREs and Maine INBRE partners, the combined efforts of the External Advisory and Steering Committees, strong institutional support, and an aggressive business strategic planning and marketing approach. COBRE Phases 1 and 2 profoundly transformed the research environment at UNE. At the time of Phase 1 submission, core research facilities were nonexistent. The increase in research capacity created through the COBRE program has led to the recruitment and funding of a critical mass of investigators, training of a skilled workforce, and development of sustainable core research facilities that can support high-quality research for UNE faculty and students, as well as external academic and industry partners. With continued institutional investment and additional support provided through Phase 3 funding, we will build on this early success and establish our center as a leader in pain research for many years to come.

慢性疼痛仍然是全世界的一个严重的健康、社会和经济问题。患者解脱是 受到当前所有止痛药的适度疗效和/或严重的自限副作用的破坏。此外， 阿片类药物的流行，由于新冠肺炎的影响，其严重性只会增加，这增加了寻找 治疗中度至重度疼痛的替代疗法。通过第一阶段和第二阶段Cobre融资和杠杆机构 在新英格兰大学疼痛和感觉功能研究中心的支持下， 改造新的实验室空间，建立两个研究核心设施，招募临界数量的调查人员 研究疼痛及其治疗。提供导师指导和职业发展支持，研究项目资金，以及 利用最先进的研究核心设施，Cobre调查人员在 发现治疗慢性疼痛的新靶点并获得近1400万美元的外部研究 资金问题。研究核心已经支持了SBIR和STTR项目，这些项目导致提交了一份 向FDA提交一期临床试验的批准。这种由科布雷基金资助的研究活动的增加 在很大程度上是UNE最近被卡内基提升到R2状态(表示为高研究活动)的主要原因 高等学校分类。Cobre第三阶段将在之前成功的基础上，确保 中心的长期生存能力。将继续以专用核心空间的形式提供强有力的机构支助， 设备维护、研究核心代金券计划的内部资金、核心董事的发放时间以及 保证核心员工的工资超过第三阶段。对于目标1，Cobre团队将继续增加研究能力 通过职业发展规划和对试点研究项目的直接财政支持。试点项目 该计划将接受来自联合国大学教职员工和地区合作机构的申请，以支持利用 核心设施，并有可能导致外部资金。这种方法将增加研究的核心用户群 并协助目标2，将研究核心转变为可持续资源，提供专业知识、培训和国家- 为UNE和更广泛的科学界提供最先进的仪器，以进行尖端的生物医学 研究。研究核心将通过与区域科布雷和缅因州INBRE的合作而变得可持续 合作伙伴，外部咨询和指导委员会的共同努力，强有力的机构支持，以及 积极进取的业务战略规划和营销方法。科布雷第一阶段和第二阶段深刻地改变了 UNE的研究环境。在第一阶段提交时，核心研究设施还不存在。涨幅 通过科布雷计划建立的研究能力已经导致招募和资助了临界质量的 调查人员，培训熟练的劳动力，以及开发可持续的核心研究设施，以支持 为加州大学的教职员工和学生以及外部学术和行业合作伙伴提供高质量的研究。(续) 机构投资和通过第三阶段资金提供的额外支持，我们将在早期成功的基础上， 使我们的中心在未来多年成为疼痛研究的领先者。