Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function

疼痛和感觉功能研究跨学科卓越中心

• 批准号: 10414545
• 负责人: IAN D MENG
• 金额: $ 104.13万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414545
• 关键词: Acute Pain; Advisory Committees; Affect; Applications Grants; Award; Behavior; Biological; Biomedical Research; Businesses; COVID-19 impact; Centers of Research Excellence; Classification; Clinical; Collaborations; Communities; Consultations; Continuing Education; Contract Services; Contracts; Core Facility; Development; Doctor of Philosophy; Economics; Educational workshop; Engineering; Environment; Epidemic; Equipment; Extramural Activities; Faculty; Fee-for-Service Plans; Fees; Fellowship; Financial Support; Funding; Goals; Grant; Health; Histology; Human Resources; Image; Immune; Income; Individual; Industry; Institutes; Institution; Intervention; Investments; Joints; Journals; Laboratories; Lead; Learning; Maine; Maintenance; Marketing; Medical Research; Mentorship; Neurons; Neurosciences; New England; New Hampshire; Opioid; Pain; Pain Research; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Phase I Clinical Trials; Pilot Projects; Population; Program Development; Program Research Project Grants; Publications; Quality of life; Research; Research Activity; Research Institute; Research Personnel; Research Project Grants; Research Support; Science; Scientific Advances and Accomplishments; Secure; Sensory; Series; Services; Severities; Signal Pathway; Signal Transduction; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Strategic Planning; Students; Sustainable Development; Time; Training; Travel; Universities; Wages; Work; Workforce Development; addiction liability; alternative treatment; base; career development; chronic pain; chronic pain management; functional improvement; higher education; industry partner; innovation; instrumentation; investigator training; novel; opioid epidemic; pain chronification; pain relief; prescription opioid; prevent; programs; recruit; research and development; research facility; restoration; reuptake; side effect; social; success; sustainable resource; voucher

Chronic pain continues to be a critical health, social and economic issue throughout the world. Patient relief is undermined by modest efficacy and/or serious, self-limiting side effects of all current pain pharmaceuticals. Moreover, the opioid epidemic, that has only increased in severity as a consequence of COVID-19, lends urgency to the search for alternative treatments for moderate to severe pain. Through Phase 1 and 2 COBRE funding and leveraged institutional support, the University of New England (UNE) Center for the Study of Pain and Sensory Function was successful in renovating new laboratory space, establishing two research core facilities, and recruiting a critical mass of investigators studying pain and its treatment. Provided with mentorship and career development support, research project funding, and access to state-of-the-art research core facilities, COBRE investigators have made major scientific advances in the discovery of novel targets for the treatment of chronic pain and secured almost $14 million in extramural research funding. The research cores have already supported SBIR and STTR projects that have led to the submission of one compound to the FDA for approval of Phase 1 clinical trials. This increase in research activity seeded by COBRE funds was largely responsible for UNE’s recent promotion to R2 status (denoted as high research activity) by the Carnegie Classification of Institutions of Higher Education. COBRE Phase 3 will build on its previous successes to secure the Center’s long-term viability. Strong institutional support will continue to be provided in the form of dedicated core space, equipment maintenance, internal funding for a research core voucher program, release time for core Directors and guarantee of core staff salary beyond Phase 3. For Aim 1, the COBRE team will continue to increase research capacity through career development programming and direct financial support for pilot research projects. The Pilot Project Program will accept applications from faculty at UNE and regional partner institutions to support projects that utilize the core facilities and have the potential to lead to extramural funding. This approach will increase the research core user base and assist in Aim 2, transitioning the research cores into sustainable resources that provide expertise, training, and state- of-the-art instrumentation to the UNE and broader scientific communities for conducting cutting-edge biomedical research. The research cores will become sustainable through collaborations with regional COBREs and Maine INBRE partners, the combined efforts of the External Advisory and Steering Committees, strong institutional support, and an aggressive business strategic planning and marketing approach. COBRE Phases 1 and 2 profoundly transformed the research environment at UNE. At the time of Phase 1 submission, core research facilities were nonexistent. The increase in research capacity created through the COBRE program has led to the recruitment and funding of a critical mass of investigators, training of a skilled workforce, and development of sustainable core research facilities that can support high-quality research for UNE faculty and students, as well as external academic and industry partners. With continued institutional investment and additional support provided through Phase 3 funding, we will build on this early success and establish our center as a leader in pain research for many years to come.

慢性疼痛仍然是全世界重要的健康、社会和经济问题。患者的缓解是 目前所有止痛药物的功效有限和/或严重的自限性副作用削弱了这一点。此外， 由于 COVID-19，阿片类药物流行病的严重程度只增不减，这使得寻找阿片类药物变得紧迫 中度至重度疼痛的替代疗法。通过第一阶段和第二阶段 COBRE 资金和杠杆机构 在新英格兰大学 (UNE) 疼痛和感觉功能研究中心的支持下， 翻新新的实验室空间，建立两个研究核心设施，并招募足够数量的研究人员 研究疼痛及其治疗。提供指导和职业发展支持、研究项目资助，以及 通过使用最先进的研究核心设施，COBRE 研究人员在以下领域取得了重大科学进展： 发现治疗慢性疼痛的新靶点并获得近 1400 万美元的外部研究资金 资金。研究核心已经支持 SBIR 和 STTR 项目，这些项目已提交一份 化合物向 FDA 批准 1 期临床试验。 COBRE 基金资助的研究活动有所增加 UNE 最近被卡内基基金会提升为 R2 地位（表示高研究活动） 高等教育机构的分类。 COBRE 第 3 阶段将在其先前成功的基础上确保 中心的长期生存能力。将继续以专用核心空间的形式提供强有力的机构支持， 设备维护、研究核心券计划的内部资金、核心董事的释放时间和 保证第三阶段之后核心人员的工资。对于目标1，COBRE团队将继续提高研究能力 通过职业发展规划和对试点研究项目的直接财政支持。试点项目 该计划将接受新英格兰大学和区域合作机构教师的申请，以支持利用该项目的项目 核心设施并有可能获得外部资金。这种方法将增加研究核心用户群 协助目标 2，将研究核心转化为可持续资源，提供专业知识、培训和状态 为 UNE 和更广泛的科学界提供最先进的仪器，以进行尖端的生物医学研究 研究。通过与地区 COBRE 和缅因州 INBRE 的合作，研究核心将变得可持续 合作伙伴、外部咨询和指导委员会的共同努力、强大的机构支持以及 积极的业务战略规划和营销方法。 COBRE 第一阶段和第二阶段深刻改变了 UNE 的研究环境。在第一阶段提交时，核心研究设施还不存在。增加 通过 COBRE 计划建立的研究能力已导致招募和资助了足够数量的人员 研究人员、熟练劳动力的培训以及可持续核心研究设施的开发，以支持 为新英格兰大学教职员工和学生以及外部学术和行业合作伙伴提供高质量的研究。随着继续 机构投资和通过第三阶段资金提供的额外支持，我们将在这一早期成功的基础上再接再厉， 使我们的中心在未来多年成为疼痛研究领域的领导者。