Core B: Clinical Core

项目摘要 该U19旨在确定PD-1阻断如何影响慢性病毒诱导的人类免疫反应 和疫苗。拟议的MGH-UPenn PRIG的临床核心将是这一科学努力的核心 财团。在过去的18年里，创建了一个独特的、可扩展的样本库，并且- 以临床、免疫和遗传数据为特点的。这个储存库将得到维护，并对其进行关键的扩展 包括通过两个临床基础设施接受免疫治疗的个人的纵向样本 麻省理工学院和宾夕法尼亚大学。这一协调努力将保持高产量的样品可获得性，以催化科学 整个财团的努力，包括将样本追踪到项目1和2以及岩心C和 D.

Project Summary This U19 aims to determine how PD-1 blockade affects human immune responses induced by chronic viruses and vaccines. The Clinical Core of the proposed MGH-UPenn PRIG will be central to the scientific efforts of this consortium. A unique and expansive sample repository has been created over the last 18 years and well- characterized for clinical, immune, and genetic data. This repository will be maintained and crucially expanded to include longitudinal samples from individuals undergoing immunotherapies via clinical infrastructures at both MGH and UPenn. This concerted effort will maintain a high throughput of sample availability to catalyze scientific efforts across the consortium, including tracking samples to investigators in Projects 1 and 2 and Cores C and D.