Tissue and Clinical Core

核心C的主要目的是提供大量来自定义明确的人类样本 科研项目的患者队列和协作的技术开发核心 研究中心。和以前一样，核心的一个主要焦点将是维持一个庞大的肝组织组织库 样本来自感染和不感染丙型肝炎病毒的患者。核心还将提供和收集 结合临床资料对疾病分期和病情的组织病理学评估 此外，该核心将协调正在进行的血液/组织样本收集工作，包括收集大量样本。 通过Buffy Coat和白细胞分离方案获得PBMC，维护现有研究样本的数据库 以及相关的临床数据，并将协调组织、PBMC和血浆/血清的分布 调查人员中的样本。具体地说，核心将： 1)采集纵向标本，包括从白细胞分离中采集的大量PBMC， 接受DAA治疗的慢性丙型肝炎患者。 从… 2)维护和扩大来自慢性丙型肝炎感染者的大量PBMC， 解决了丙型肝炎病毒感染和健康对照，包括从Buffy Coats和 Leukapheresis.DD 3)维护和扩大丙型肝炎病毒感染组织和非丙型肝炎病毒对照组织的大型组织库，包括 肝脏外植体样本、手术切除样本和肝活检组织，并提供肝脏渗透 来自细针抽吸物样本的淋巴细胞。 DD 4)维护所有研究样本和现有患者信息的已建立数据库，并 协调样品收集和分发的各个方面。

The main purpose of CORE C is to provide a large number of human specimens from well-defined patient cohorts to the scientific projects and the Technology Development Core of the Collaborative Research Center. As before, a primary focus of the core will be to maintain a large tissue bank of liver tissue samples from patients with and without HCV infection. The core will also provide and collect histopathological assessment of disease stage and status in combination with clinical information Furthermore, the core will coordinate the ongoing collection of blood/tissue samples, including large numbers of PBMC via buffy coat and leukapheresis protocols, maintain databases of available research samples together with relevant clinical data and will coordinate distribution of tissue, PBMC and plasma/serum samples among the investigators. Specifically the core will: 1) Collect longitudinal specimens, including large numbers of PBMC from leukapheresis, subjects with chronic HCV infection undergoing DAA therapy. from 2) Maintain and expand a large repository of PBMC from subjects with chronic HCV infection, resolved HCV infection and healthy controls, including large numbers of PBMC from buffy coats and leukapheresis.DD 3) Maintain and expand a large tissue bank of HCV-infected and non-HCV control tissue consisting of liver explant samples, surgical resection specimens and liver biopsies and provide liver-infiltrating lymphocytes derived from fine-needle aspirate samples. DD 4) Maintain an established database of all research specimens and available patient information and coordinate all aspects of sample collection and distribution.