Core B: Clinical Core

项目摘要 U19旨在确定PD-1阻断如何影响慢性病毒诱导的人类免疫应答 和疫苗。拟议的MGH-UPenPRIG的临床核心将是本研究的科学努力的核心。 财团在过去的18年里，我们建立了一个独特而广阔的样本库， 其特征在于临床、免疫和遗传数据。该资料库将得到维护并进行重大扩充 包括来自通过临床基础设施接受免疫治疗的个体的纵向样本， MGH和UPenn。这种协调一致的努力将保持高通量的样品可用性，以催化科学研究。 整个联盟的努力，包括跟踪样品的研究人员在项目1和2和核心C和 D.

Project Summary This U19 aims to determine how PD-1 blockade affects human immune responses induced by chronic viruses and vaccines. The Clinical Core of the proposed MGH-UPenn PRIG will be central to the scientific efforts of this consortium. A unique and expansive sample repository has been created over the last 18 years and well- characterized for clinical, immune, and genetic data. This repository will be maintained and crucially expanded to include longitudinal samples from individuals undergoing immunotherapies via clinical infrastructures at both MGH and UPenn. This concerted effort will maintain a high throughput of sample availability to catalyze scientific efforts across the consortium, including tracking samples to investigators in Projects 1 and 2 and Cores C and D.