Acute HCV in the prison population

这一临床核心的目标是提供来自急性/早期患者的大量PBMC样本。 丙型肝炎病毒感染阶段，允许调查人员在整个过程中对免疫学参数进行大规模研究 协作中心。 对这一核心的资助将使人们能够继续识别急性/早期丙型肝炎病毒感染。 马萨诸塞州监狱系统。原因包括年轻注射吸毒者的数量很多 每年进入监狱系统的人，因此面临感染丙型肝炎病毒的风险。急性冠脉综合征的鉴别 丙型肝炎病毒传统上依赖于症状或实验室异常，而不是接触史，但 我们之前的资助期建立了一套基于历史风险因素的系统，以筛选早期阶段 丙型肝炎病毒感染。这份简短的1-2分钟问题调查表旨在帮助提供商识别以下人员 NSK最近通过注射吸毒获得了丙型肝炎病毒。MA状态下的成功实施 监狱系统在短时间内发现了大量急性丙型肝炎患者。在……里面 此外，该项目还极大地促进了纵向样品的采集。这是第一个 对进入监狱系统的人员进行急性丙型肝炎的系统研究，提供关键信息 关于#年急性丙型肝炎的总体患病率、临床特征和治疗结果 被监禁的人。 来自这一临床核心的资金将使这一独特而宝贵的资源继续存在 此协作中心的成员以及允许与其他检查问题的小组进行协作 不是由这笔拨款直接解决的。

The goal ofthis clinical core is to provide high numbers of samples of PBMC from subjects with acute / early phase HCV infecfion, allowing large-scale studies of immunologic parameters for investigators throughout the collaborative center. Funding of this core would allow continued identification of acute / early stage HCV infection in the Massachusetts State Prison system. Rationale includes the high number of young injection drug users entering the prison systems yearty, who are therefore at risk for HCV infection. The identification of acute HCV had traditionally been reliant on symptoms or laboratory abnormalities rather than exposure history, but our prior funding period established a system based on history-based risk factors to screen for early-stage HCV infecfion. This brief 1-2 minute quesfionnaire was designed to assist providers in identifying persons at nsk for recent acquisition of HCV by injection drug use. The successful implementation in the MA state prison system identified a large number () of persons with acute HCV over a short period of time. In addition, longitudinal sample acquisifion was greafiy enhanced by this project. This represents the first systematic study of acute HCV among persons entering the prison system, providing critical information regarding the overall prevalence, clinical characteristics, and treatment outcomes of acute HCV in incarcerated individuals. Funding from this clinical core would allow continuafion ofthis unique and valuable resource for both members ofthis Collaborative Center as well as allow collaboration with other groups examining questions not being addressed directly by this grant.