Tissue and Clinical Core

CORE C的主要目的是提供大量的人类标本， 患者队列的科学项目和技术开发核心的合作 研究中心和以前一样，核心的主要焦点将是维持一个大型的肝脏组织库 来自有和没有HCV感染的患者的样本。核心还将提供和收集 结合临床信息对疾病分期和状态进行组织病理学评估 此外，该中心还将协调正在进行的血液/组织样本收集工作，包括大量样本的收集工作 通过血沉棕黄层和白细胞分离方案，维持可用研究样本的数据库 以及相关临床数据，并将协调组织、PBMC和血浆/血清的分布 调查人员之间的样本。具体而言，核心将： 1)收集纵向标本，包括来自白细胞分离术的大量PBMC， 接受DAA治疗的慢性HCV感染患者。 从 2)维持和扩大来自慢性HCV感染受试者的PBMC的大型储存库， 解决的HCV感染和健康对照，包括来自血沉棕黄层的大量PBMC， leukapheresis.DD 3)维护和扩大HCV感染和非HCV对照组织的大型组织库， 肝移植样本、手术切除标本和肝活检，并提供肝脏浸润 淋巴细胞来源于细针抽吸样品。 DD 4)维护所有研究标本和可用患者信息的已建立数据库， 协调样品收集和分发的各个方面。

The main purpose of CORE C is to provide a large number of human specimens from well-defined patient cohorts to the scientific projects and the Technology Development Core of the Collaborative Research Center. As before, a primary focus of the core will be to maintain a large tissue bank of liver tissue samples from patients with and without HCV infection. The core will also provide and collect histopathological assessment of disease stage and status in combination with clinical information Furthermore, the core will coordinate the ongoing collection of blood/tissue samples, including large numbers of PBMC via buffy coat and leukapheresis protocols, maintain databases of available research samples together with relevant clinical data and will coordinate distribution of tissue, PBMC and plasma/serum samples among the investigators. Specifically the core will: 1) Collect longitudinal specimens, including large numbers of PBMC from leukapheresis, subjects with chronic HCV infection undergoing DAA therapy. from 2) Maintain and expand a large repository of PBMC from subjects with chronic HCV infection, resolved HCV infection and healthy controls, including large numbers of PBMC from buffy coats and leukapheresis.DD 3) Maintain and expand a large tissue bank of HCV-infected and non-HCV control tissue consisting of liver explant samples, surgical resection specimens and liver biopsies and provide liver-infiltrating lymphocytes derived from fine-needle aspirate samples. DD 4) Maintain an established database of all research specimens and available patient information and coordinate all aspects of sample collection and distribution.