Vascular Biology, Signaling and Therapeutics training program

摘要 这项培训补助金申请的重点是血管生物学，信号传导和治疗开发（VBST）， 为4名博士前和2名博士后学员设计。血管研究人员越来越多地在一个 多学科环境，他们寻求不同的目标，从基础发现研究， 将新发现转化为实验疗法。因此，培养下一代的 血管生物学家需要前和博士后从事高度定义的研究，同时也获得交叉， 学科合作研究技能和翻译机会的理解。我们的使命是 使用多学科的培训方法，以培养杰出的血管生物学家， 学术界、研究机构和生物制药竞技场。VBST培训计划组织 围绕四个主题领域的研究培训：（1）血管信号，（2）血管生成和再生， (3)血管治疗学和（4）神经血管生物学。我们的组织优势包括 血管生物学专业知识和一批高素质的科学家在培训工作，在一个令人兴奋的， 多学科环境。导师的专业知识来自9个部门（生理学和生物物理学， 解剖学和细胞生物学，药理学，运动机能学，眼科学，神经学，医学， 生物工程，牙科）和4个学院（医学，工程，应用健康科学，牙科）和 VBST与3个临床和转化实体（心血管研究中心（CCVR）， 临床翻译科学中心（CCTS），包括UICentre for Drug Discovery和 芝加哥生物医学联盟（CBC）。培训生的教育计划包括课程 活动和药物开发和临床试验的合作培训，与制药和大学， 基于中心。VBST培训机会可通过与礼来、艾伯维和 基因泰克为了促进合作和扩大研究范围，每个学员都有两名导师， 来自不同的主题领域，所有学员都有与心血管相关的课程活动 治疗学在进入该计划后，学员将制定个人发展计划（IDP）， 他们的导师，并将征求意见的主题领导人。因此，学员有充足的机会 在该领域专家的支持下逐步走向独立。我们将充实所有VBST学员 通过要求参加VBST年度务虚会，年度NAVBO-VASCULATA课程，生存 技能研讨会，期刊俱乐部和职业建议，强调生物医学领域的道德和可重复性 科学因此，VBST将提供一个令人兴奋的，多学科的，严格的计划，并将准备 博士前和博士后学员成为最高水平的血管科学家。这些青年科学家 将能够进行前沿研究，团队合作，了解当前的景观， 心血管疾病和加速发现治疗。

ABSTRACT This training grant application is focused on vascular biology, signaling, and therapeutic development (VBST), and is designed for 4 pre-doctoral and 2 postdoctoral trainees. Vascular researchers increasingly work in a multi-disciplinary environment in which they seek diverse goals, from fundamental discovery research to translation of new findings into experimental therapeutics. Consequently, training of the next generation of vascular biologist requires pre- and postdocs to engage in highly defined research while also acquiring cross- disciplinary collaborative research skills and an understanding of translational opportunities. Our mission is to use a multi-disciplinary training approach in order to develop eminent vascular biologists with careers in academia, research institutions, and the biopharmaceutical arena. The VBST Training Program is organized around four thematic areas of research training: (1) Vascular Signaling, (2) Angiogenesis and Regeneration, (3) Vascular Therapeutics, and (4) Neurovascular Biology. Our organizational strengths include depth of vascular biology expertise and a highly-qualified cohort of scientists-in-training working in an exciting and multi-disciplinary environment. Mentor expertise is drawn from 9 departments (Physiology and Biophysics, Anatomy and Cell Biology, Pharmacology, Kinesiology, Ophthalmology, Neurology, Medicine, Bioengineering, Dentistry) and 4 Colleges (Medicine, Engineering, Applied Health Sciences, Dentistry) and VBST is associated with 3 clinical and translational entities (Center for Cardiovascular Research (CCVR), Center for Clinical Translation Science (CCTS) which includes the UICentre for Drug Discovery, and the Chicago Biomedical Consortium (CBC). An educational program for trainees encompasses curricular activities and collaborative training in drug development and clinical trials, with both pharma and university- based centers. VBST training opportunities are available via partnerships with Eli Lilly, AbbVie, and Genentech. To foster collaboration and extend the scope of research, each trainee has two mentors that are drawn from a different thematic area, and all trainees have curricular activities related to cardiovascular therapeutics. Upon entry into the program, trainees will formulate an Individual Development Plan (IDP) with their mentors' guidance, and will elicit advice from Theme Leaders. Thus, trainees have ample opportunities to advance to independence through support from experts in the field. We will enrich all the VBST trainees through required participation in VBST Annual Retreat, annual NAVBO-VASCULATA coursework, survival skills workshop, journal club, and career advice that underscore ethics and reproducibility in biomedical science. Thus, the VBST will provide an exciting, multi-disciplinary, and rigorous program and will prepare pre- and postdoctoral trainees to become vascular scientists of the highest caliber. These young scientists will be able to conduct cutting-edge research, work in teams, understand the current landscape of cardiovascular diseases and accelerate discoveries into treatment.