Vascular Biology, Signaling and Therapeutics training program

血管生物学、信号传导和治疗学培训计划

基本信息

批准号：
10646394
负责人：
Jan K. Kitajewski
金额：
$ 37.58万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10646394
关键词：
Biology Blood Vessels Signal Transduction Therapeutic Training Programs

项目摘要

ABSTRACT This training grant application is focused on vascular biology, signaling, and therapeutic development (VBST), and is designed for 4 pre-doctoral and 2 postdoctoral trainees. Vascular researchers increasingly work in a multi-disciplinary environment in which they seek diverse goals, from fundamental discovery research to translation of new findings into experimental therapeutics. Consequently, training of the next generation of vascular biologist requires pre- and postdocs to engage in highly defined research while also acquiring cross- disciplinary collaborative research skills and an understanding of translational opportunities. Our mission is to use a multi-disciplinary training approach in order to develop eminent vascular biologists with careers in academia, research institutions, and the biopharmaceutical arena. The VBST Training Program is organized around four thematic areas of research training: (1) Vascular Signaling, (2) Angiogenesis and Regeneration, (3) Vascular Therapeutics, and (4) Neurovascular Biology. Our organizational strengths include depth of vascular biology expertise and a highly-qualified cohort of scientists-in-training working in an exciting and multi-disciplinary environment. Mentor expertise is drawn from 9 departments (Physiology and Biophysics, Anatomy and Cell Biology, Pharmacology, Kinesiology, Ophthalmology, Neurology, Medicine, Bioengineering, Dentistry) and 4 Colleges (Medicine, Engineering, Applied Health Sciences, Dentistry) and VBST is associated with 3 clinical and translational entities (Center for Cardiovascular Research (CCVR), Center for Clinical Translation Science (CCTS) which includes the UICentre for Drug Discovery, and the Chicago Biomedical Consortium (CBC). An educational program for trainees encompasses curricular activities and collaborative training in drug development and clinical trials, with both pharma and university- based centers. VBST training opportunities are available via partnerships with Eli Lilly, AbbVie, and Genentech. To foster collaboration and extend the scope of research, each trainee has two mentors that are drawn from a different thematic area, and all trainees have curricular activities related to cardiovascular therapeutics. Upon entry into the program, trainees will formulate an Individual Development Plan (IDP) with their mentors' guidance, and will elicit advice from Theme Leaders. Thus, trainees have ample opportunities to advance to independence through support from experts in the field. We will enrich all the VBST trainees through required participation in VBST Annual Retreat, annual NAVBO-VASCULATA coursework, survival skills workshop, journal club, and career advice that underscore ethics and reproducibility in biomedical science. Thus, the VBST will provide an exciting, multi-disciplinary, and rigorous program and will prepare pre- and postdoctoral trainees to become vascular scientists of the highest caliber. These young scientists will be able to conduct cutting-edge research, work in teams, understand the current landscape of cardiovascular diseases and accelerate discoveries into treatment.

抽象的该培训赠款的应用集中在血管生物学，信号传导和治疗开发（VBST）上，并专为4名博士后和2名博士后学员而设计。血管研究人员越来越多地在他们寻求各种目标的多学科环境，从基本发现研究到将新发现转化为实验治疗学。因此，培训下一代血管生物学家需要前和博士后才能进行高度定义的研究，同时还获得了交叉纪律协作研究技能和对翻译机会的理解。我们的使命是使用多学科培训方法，以发展重要的血管生物学家学术机构，研究机构和生物制药领域。 VBST培训计划是组织的研究培训的四个主题领域：（1）血管信号传导，（2）血管生成和再生，（3）血管疗法和（4）神经血管生物学。我们的组织优势包括血管生物学专业知识和高度资格多学科环境。导师专业知识来自9个部门（生理学和生物物理学，解剖学和细胞生物学，药理学，运动机能学，眼科，神经病学，医学，生物工程，牙科）和4所大学（医学，工程，应用健康科学，牙科）和 VBST与3个临床和转化实体有关（心血管研究中心（CCVR），临床翻译科学中心（CCTS），其中包括用于药物发现的Uicentre和芝加哥生物医学财团（CBC）。针对学员的教育计划包括课程药物开发和临床试验的活动和协作培训，以及制药和大学 - 基于中心。 VBST培训机会可通过与Eli Lilly，Abbvie和 Genentech。为了促进协作和扩展研究范围，每个学员都有两个导师从不同的主题领域绘制，所有学员都有与心血管有关的课程活动疗法。进入该计划后，学员将与他们的导师的指导，并将引起主题领导者的建议。因此，学员有足够的机会通过该领域专家的支持来促进独立。我们将丰富所有VBST学员通过要求参加VBST年度务虚会，年度NAVBO-Stasculata课程，生存技能研讨会，期刊俱乐部和职业建议，强调了生物医学中的道德和可重复性科学。因此，VBST将提供一个令人兴奋的，多学科和严格的程序，并将准备博士后学员将成为最高口径的血管科学家。这些年轻的科学家将能够进行最先进的研究，团队合作，了解当前的格局心血管疾病并将发现加速到治疗。