Vascular Biology, Signaling and Therapeutics training program

血管生物学、信号传导和治疗学培训计划

• 批准号: 10646394
• 负责人: Jan K. Kitajewski
• 金额: $ 37.58万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10646394
• 关键词: Biology; Blood Vessels; Signal Transduction; Therapeutic; Training Programs

ABSTRACT This training grant application is focused on vascular biology, signaling, and therapeutic development (VBST), and is designed for 4 pre-doctoral and 2 postdoctoral trainees. Vascular researchers increasingly work in a multi-disciplinary environment in which they seek diverse goals, from fundamental discovery research to translation of new findings into experimental therapeutics. Consequently, training of the next generation of vascular biologist requires pre- and postdocs to engage in highly defined research while also acquiring cross- disciplinary collaborative research skills and an understanding of translational opportunities. Our mission is to use a multi-disciplinary training approach in order to develop eminent vascular biologists with careers in academia, research institutions, and the biopharmaceutical arena. The VBST Training Program is organized around four thematic areas of research training: (1) Vascular Signaling, (2) Angiogenesis and Regeneration, (3) Vascular Therapeutics, and (4) Neurovascular Biology. Our organizational strengths include depth of vascular biology expertise and a highly-qualified cohort of scientists-in-training working in an exciting and multi-disciplinary environment. Mentor expertise is drawn from 9 departments (Physiology and Biophysics, Anatomy and Cell Biology, Pharmacology, Kinesiology, Ophthalmology, Neurology, Medicine, Bioengineering, Dentistry) and 4 Colleges (Medicine, Engineering, Applied Health Sciences, Dentistry) and VBST is associated with 3 clinical and translational entities (Center for Cardiovascular Research (CCVR), Center for Clinical Translation Science (CCTS) which includes the UICentre for Drug Discovery, and the Chicago Biomedical Consortium (CBC). An educational program for trainees encompasses curricular activities and collaborative training in drug development and clinical trials, with both pharma and university- based centers. VBST training opportunities are available via partnerships with Eli Lilly, AbbVie, and Genentech. To foster collaboration and extend the scope of research, each trainee has two mentors that are drawn from a different thematic area, and all trainees have curricular activities related to cardiovascular therapeutics. Upon entry into the program, trainees will formulate an Individual Development Plan (IDP) with their mentors' guidance, and will elicit advice from Theme Leaders. Thus, trainees have ample opportunities to advance to independence through support from experts in the field. We will enrich all the VBST trainees through required participation in VBST Annual Retreat, annual NAVBO-VASCULATA coursework, survival skills workshop, journal club, and career advice that underscore ethics and reproducibility in biomedical science. Thus, the VBST will provide an exciting, multi-disciplinary, and rigorous program and will prepare pre- and postdoctoral trainees to become vascular scientists of the highest caliber. These young scientists will be able to conduct cutting-edge research, work in teams, understand the current landscape of cardiovascular diseases and accelerate discoveries into treatment.

摘要 这项培训拨款申请的重点是血管生物学、信号和治疗开发(VBST)， 专为4名博士后和2名博士后学员设计。血管研究人员越来越多地在 多学科环境，他们在其中寻求不同的目标，从基础发现研究到 将新发现转化为实验治疗学。因此，培训下一代 血管生物学家要求博士后和博士后从事高度明确的研究，同时获得 学科协作研究技能和对翻译机会的理解。我们的任务是 使用多学科培训方法，以培养具有以下职业生涯的杰出血管生物学家 学术界、研究机构和生物制药领域。组织了VBST培训计划 围绕研究培训的四个主题领域：(1)血管信号，(2)血管生成和再生， (3)血管治疗学；(4)神经血管生物学。我们的组织优势包括深度 血管生物学专业知识和一批高素质的受训科学家在一个令人兴奋和 多学科环境。导师的专业知识来自9个系(生理学和生物物理学， 解剖学和细胞生物学、药理学、运动学、眼科学、神经学、医学 生物工程、牙科)和4所学院(医学、工程、应用健康科学、牙科)和 VBST与3个临床和翻译实体(心血管研究中心(CCVR)、 临床翻译科学中心(CCTS)，其中包括UICenter for药物发现，以及 芝加哥生物医学联盟(CBC)。针对受训人员的教育计划包括课程 与制药公司和大学在药物开发和临床试验方面的活动和协作培训- 以中心为基础。VBST培训机会可通过与礼来公司、AbbVie和 基因泰克。为了促进合作和扩大研究范围，每个学员都有两位导师，他们是 来自不同的主题领域，所有受训人员都有与心血管相关的课程活动 治疗学。在进入该计划后，学员将与以下人员一起制定个人发展计划(IDP 他们的导师的指导，并将从主题领导人的建议。因此，学员有充足的机会 在该领域专家的支持下迈向独立。我们将充实所有VBST实习生 通过参加VBST年度务虚会、NAVBO-VASCULATA年度课程、生存 技能研讨会、期刊俱乐部和职业建议，强调生物医学的伦理和可再生性 科学。因此，VBST将提供一个令人兴奋的、多学科的和严格的课程，并将准备 博士后和博士后培训，成为最高素质的血管科学家。这些年轻的科学家 将能够进行尖端研究，团队合作，了解当前的格局 心血管疾病，并加速发现进入治疗。

项目成果

The Role of the Tumor Microenvironment in Developing Successful Therapeutic and Secondary Prophylactic Breast Cancer Vaccines.

肿瘤微环境在开发成功的治疗性和二级预防性乳腺癌疫苗中的作用。

• DOI: 10.3390/vaccines8030529
• 发表时间: 2020-09-14
• 期刊: Vaccines
• 影响因子: 7.8
• 作者: Gordon B;Gadi VK
• 通讯作者: Gadi VK

VEGF Induces Expression of Genes That Either Promote or Limit Relaxation of the Retinal Endothelial Barrier.

• DOI: 10.3390/ijms24076402
• 发表时间: 2023-03-29
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: McCann, Maximilian;Li, Yueru;Baccouche, Basma;Kazlauskas, Andrius
• 通讯作者: Kazlauskas, Andrius