Vascular Biology, Signaling and Therapeutics training program

血管生物学、信号传导和治疗学培训计划

• 批准号: 10646394
• 负责人: Jan K. Kitajewski
• 金额: $ 37.58万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10646394
• 关键词: Biology; Blood Vessels; Signal Transduction; Therapeutic; Training Programs

ABSTRACT This training grant application is focused on vascular biology, signaling, and therapeutic development (VBST), and is designed for 4 pre-doctoral and 2 postdoctoral trainees. Vascular researchers increasingly work in a multi-disciplinary environment in which they seek diverse goals, from fundamental discovery research to translation of new findings into experimental therapeutics. Consequently, training of the next generation of vascular biologist requires pre- and postdocs to engage in highly defined research while also acquiring cross- disciplinary collaborative research skills and an understanding of translational opportunities. Our mission is to use a multi-disciplinary training approach in order to develop eminent vascular biologists with careers in academia, research institutions, and the biopharmaceutical arena. The VBST Training Program is organized around four thematic areas of research training: (1) Vascular Signaling, (2) Angiogenesis and Regeneration, (3) Vascular Therapeutics, and (4) Neurovascular Biology. Our organizational strengths include depth of vascular biology expertise and a highly-qualified cohort of scientists-in-training working in an exciting and multi-disciplinary environment. Mentor expertise is drawn from 9 departments (Physiology and Biophysics, Anatomy and Cell Biology, Pharmacology, Kinesiology, Ophthalmology, Neurology, Medicine, Bioengineering, Dentistry) and 4 Colleges (Medicine, Engineering, Applied Health Sciences, Dentistry) and VBST is associated with 3 clinical and translational entities (Center for Cardiovascular Research (CCVR), Center for Clinical Translation Science (CCTS) which includes the UICentre for Drug Discovery, and the Chicago Biomedical Consortium (CBC). An educational program for trainees encompasses curricular activities and collaborative training in drug development and clinical trials, with both pharma and university- based centers. VBST training opportunities are available via partnerships with Eli Lilly, AbbVie, and Genentech. To foster collaboration and extend the scope of research, each trainee has two mentors that are drawn from a different thematic area, and all trainees have curricular activities related to cardiovascular therapeutics. Upon entry into the program, trainees will formulate an Individual Development Plan (IDP) with their mentors' guidance, and will elicit advice from Theme Leaders. Thus, trainees have ample opportunities to advance to independence through support from experts in the field. We will enrich all the VBST trainees through required participation in VBST Annual Retreat, annual NAVBO-VASCULATA coursework, survival skills workshop, journal club, and career advice that underscore ethics and reproducibility in biomedical science. Thus, the VBST will provide an exciting, multi-disciplinary, and rigorous program and will prepare pre- and postdoctoral trainees to become vascular scientists of the highest caliber. These young scientists will be able to conduct cutting-edge research, work in teams, understand the current landscape of cardiovascular diseases and accelerate discoveries into treatment.

抽象的 该培训补助金申请重点关注血管生物学、信号传导和治疗开发（VBST）， 专为 4 名博士前学员和 2 名博士后学员设计。血管研究人员越来越多地在 他们寻求不同目标的多学科环境，从基础发现研究到 将新发现转化为实验疗法。因此，下一代的培训 血管生物学家要求博士前和博士后从事高度明确的研究，同时获得交叉 学科合作研究技能和对转化机会的理解。我们的使命是 采用多学科培训方法，培养从事以下领域工作的杰出血管生物学家 学术界、研究机构和生物制药领域。 VBST培训计划举办 围绕四个主题领域的研究培训：(1) 血管信号转导，(2) 血管生成和再生， (3) 血管治疗学，(4) 神经血管生物学。我们的组织优势包括深度 血管生物学专业知识和高素质的受训科学家队伍在令人兴奋和 多学科环境。导师的专业知识来自 9 个系（生理学和生物物理学、 解剖学和细胞生物学、药理学、运动机能学、眼科、神经病学、医学、 生物工程、牙科）和 4 个学院（医学、工程、应用健康科学、牙科）和 VBST 与 3 个临床和转化实体相关（心血管研究中心 (CCVR)、 临床转化科学中心 (CCTS)，包括 UI 药物发现中心和 芝加哥生物医学联盟 (CBC)。学员教育计划包括课程 与制药公司和大学在药物开发和临床试验方面的活动和合作培训 设中心。通过与礼来 (Eli Lilly)、艾伯维 (AbbVie) 和 基因泰克。为了促进合作并扩大研究范围，每个学员都有两名导师，分别是 来自不同主题领域，所有学员都有与心血管相关的课程活动 疗法。进入该计划后，学员将制定个人发展计划（IDP） 他们的导师的指导，并将征求主题领袖的建议。因此，学员有充足的机会 通过该领域专家的支持迈向独立。我们将充实所有VBST学员 通过参加 VBST 年度静修、年度 NAVBO-VASCULATA 课程、生存 强调生物医学道德和可重复性的技能研讨会、期刊俱乐部和职业建议 科学。因此，VBST 将提供令人兴奋的、多学科的、严格的课程，并将准备 博士前和博士后学员成为最高水平的血管科学家。这些年轻的科学家 将能够进行前沿研究、团队合作、了解当前的形势 心血管疾病并加速治疗的发现。

项目成果

The Role of the Tumor Microenvironment in Developing Successful Therapeutic and Secondary Prophylactic Breast Cancer Vaccines.

肿瘤微环境在开发成功的治疗性和二级预防性乳腺癌疫苗中的作用。

• DOI: 10.3390/vaccines8030529
• 发表时间: 2020-09-14
• 期刊: Vaccines
• 影响因子: 7.8
• 作者: Gordon B;Gadi VK
• 通讯作者: Gadi VK

VEGF Induces Expression of Genes That Either Promote or Limit Relaxation of the Retinal Endothelial Barrier.

• DOI: 10.3390/ijms24076402
• 发表时间: 2023-03-29
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: McCann, Maximilian;Li, Yueru;Baccouche, Basma;Kazlauskas, Andrius
• 通讯作者: Kazlauskas, Andrius