Drug Discovery in Infectious Disease Training

传染病培训中的药物发现

• 批准号: 10190818
• 负责人: Robert Virgil Stahelin
• 金额: $ 19.81万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-12 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10190818
• 关键词: Communicable Diseases; Training; drug discovery

Project Summary While treatments for eradicating some infectious diseases have been successful, there is still a large gap in the treatment of infections caused by bacteria, viruses, fungi and parasites, in particular as drug resistance continues to grow as a problem. To address this evolving issue, scientists are needed who are trained to understand how pathogens interact with the host, in order to better uncover opportunities and strategies for drug discovery. This training program’s goal is to address this need by providing qualified graduate students with broad training in infectious diseases and drug discovery, complemented by professional development opportunities, that prepares them for a long productive career in infectious disease related research. The training program includes 21 faculty members from 6 departments across 4 different colleges at Purdue University. These faculty members have diverse and complementary research interests in infectious disease, drug discovery and drug delivery, structural biology, and molecular biology. All of these faculty members are part of the Purdue Institute of Inflammation, Immunology and Infectious Disease and the Purdue Institute for Drug Discovery. These institutes bring faculty and trainees together through shared research space, a seminar series, journal clubs, and social events, resulting in a unique and supportive training environment for the “Drug Discovery in Infectious Disease Training” program. In this program, students will develop expertise both in infectious disease and in drug discovery. Specifically, trainees will take a course focused on: 1) infectious diseases and drug discovery and 2) biological membranes (a common theme of pathogen entry, exit and replication). To promote responsible, rigorous and reproducible research practices, students will complete courses in statistical analysis and the responsible conduct in research. To develop written communication skills, trainees also will take a grant-writing course, where they participate in a collaborative, active learning environment to gain feedback on the development of an NIH F31 style proposal. Additional training activities include participating in a seminar series, attending regional/national scientific meetings, and completing a capstone project in the area of drug discovery in infectious disease. In completing this semester-long capstone project, trainees will build teamwork, critical thinking and data analysis skills, all while working in the context of drug discovery and infectious disease. The capstone project will be complemented with networking and learning opportunities with industrial partners who are developing new drugs for infectious diseases. Further, fellows have the opportunity to engage in entrepreneurial training, an important aspect of academic drug discovery. Using a jointly developed Individual Development Plan, the trainees and mentors will create a training plan that is tailored towards the students’ training needs and career goals. In the end, the training program will have helped students work towards their desired career goals, while also developing a workforce with a unique skillset for addressing the challenges of discovering therapies for infectious disease. !

项目摘要 虽然根除一些传染病的治疗方法已经取得成功，但在预防和治疗方面仍然存在很大差距。 治疗由细菌、病毒、真菌和寄生虫引起的感染，特别是在耐药性持续存在时 成长为一个问题为了解决这一不断演变的问题，需要受过培训的科学家来了解如何 病原体与宿主相互作用，以便更好地发现药物发现的机会和策略。这 培训计划的目标是通过为合格的研究生提供广泛的培训来满足这一需求， 传染病和药物发现，辅以专业发展机会，准备 他们在传染病相关研究方面的长期富有成效的职业生涯。培训计划包括21名教师 来自普渡大学4个不同学院6个系的成员。这些教师有 在传染病，药物发现和药物输送，结构， 生物学和分子生物学所有这些教员都是普渡大学炎症研究所的一部分， 免疫学和传染病和普渡药物发现研究所。这些机构带来了教职员工 通过共享研究空间、系列研讨会、期刊俱乐部和社交活动， 为“传染病药物研发培训”提供了独特的支持性培训环境 程序.在这个项目中，学生将发展传染病和药物发现方面的专业知识。 具体而言，学员将参加一个课程，重点是：1）传染病和药物发现和2）生物 膜（病原体进入、离开和复制的共同主题）。促进负责任、严谨和 可重复的研究实践，学生将完成统计分析和负责的课程 进行研究。为了培养书面沟通技巧，学员还将参加赠款写作课程， 在那里，他们参加了一个合作，积极的学习环境，以获得反馈的发展， NIH F31样式提案。其他培训活动包括参加一系列研讨会， 区域/国家科学会议，并完成传染病药物发现领域的顶点项目 疾病在完成这个为期一个学期的顶点项目，学员将建立团队合作，批判性思维和 数据分析技能，同时在药物发现和传染病的背景下工作。尖顶石 该项目将与工业合作伙伴建立联系和学习机会， 研发治疗传染病的新药此外，研究员有机会从事创业活动， 培训是学术药物发现的一个重要方面。通过共同制定的个人发展计划， 学员和导师将根据学员的培训需求制定培训计划， 职业目标。最终，培训计划将帮助学生朝着他们理想的职业目标努力， 同时也培养了一支具有独特技能的员工队伍，以应对发现疗法的挑战， 传染病 !