Drug Discovery in Infectious Disease Training

传染病培训中的药物发现

• 批准号: 10380751
• 负责人: Robert Virgil Stahelin
• 金额: $ 20.74万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-12 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10380751
• 关键词: Communicable Diseases; Training; drug discovery

Project Summary While treatments for eradicating some infectious diseases have been successful, there is still a large gap in the treatment of infections caused by bacteria, viruses, fungi and parasites, in particular as drug resistance continues to grow as a problem. To address this evolving issue, scientists are needed who are trained to understand how pathogens interact with the host, in order to better uncover opportunities and strategies for drug discovery. This training program’s goal is to address this need by providing qualified graduate students with broad training in infectious diseases and drug discovery, complemented by professional development opportunities, that prepares them for a long productive career in infectious disease related research. The training program includes 21 faculty members from 6 departments across 4 different colleges at Purdue University. These faculty members have diverse and complementary research interests in infectious disease, drug discovery and drug delivery, structural biology, and molecular biology. All of these faculty members are part of the Purdue Institute of Inflammation, Immunology and Infectious Disease and the Purdue Institute for Drug Discovery. These institutes bring faculty and trainees together through shared research space, a seminar series, journal clubs, and social events, resulting in a unique and supportive training environment for the “Drug Discovery in Infectious Disease Training” program. In this program, students will develop expertise both in infectious disease and in drug discovery. Specifically, trainees will take a course focused on: 1) infectious diseases and drug discovery and 2) biological membranes (a common theme of pathogen entry, exit and replication). To promote responsible, rigorous and reproducible research practices, students will complete courses in statistical analysis and the responsible conduct in research. To develop written communication skills, trainees also will take a grant-writing course, where they participate in a collaborative, active learning environment to gain feedback on the development of an NIH F31 style proposal. Additional training activities include participating in a seminar series, attending regional/national scientific meetings, and completing a capstone project in the area of drug discovery in infectious disease. In completing this semester-long capstone project, trainees will build teamwork, critical thinking and data analysis skills, all while working in the context of drug discovery and infectious disease. The capstone project will be complemented with networking and learning opportunities with industrial partners who are developing new drugs for infectious diseases. Further, fellows have the opportunity to engage in entrepreneurial training, an important aspect of academic drug discovery. Using a jointly developed Individual Development Plan, the trainees and mentors will create a training plan that is tailored towards the students’ training needs and career goals. In the end, the training program will have helped students work towards their desired career goals, while also developing a workforce with a unique skillset for addressing the challenges of discovering therapies for infectious disease. !

项目摘要 虽然根除一些传染病的治疗方法取得了成功，但在以下方面仍有很大差距 治疗细菌、病毒、真菌和寄生虫引起的感染，特别是在耐药性持续存在的情况下 作为一个问题而增长。为了解决这个不断演变的问题，需要经过培训的科学家了解如何 病原体与宿主相互作用，以便更好地发现药物发现的机会和策略。这 培训计划的目标是通过为合格的研究生提供广泛的培训来满足这一需求 传染病和药物发现，辅之以职业发展机会，为 他们长期从事与传染病相关的富有成效的研究工作。培训计划包括21名教职员工 成员来自普渡大学4个不同学院的6个系。这些教职员工有 在传染病、药物发现和药物输送、结构和结构方面的不同和互补的研究兴趣 生物学和分子生物学。所有这些教职员工都是普渡炎症研究所的一部分， 免疫学和传染病和普渡药物研发研究所。这些学院带来了教师 通过共享研究空间、系列研讨会、期刊俱乐部和社交活动， 为《传染病药物发现培训》营造独特的支持性培训环境 程序。在这个项目中，学生将发展传染病和药物发现方面的专业知识。 具体地说，受训人员将学习以下课程：1)传染病和药物发现；2)生物学 细胞膜(病原体进入、离开和复制的共同主题)。倡导负责任、严谨、 可重复的研究实践，学生将完成统计分析和负责任的课程 研究中的行为。为了培养书面沟通能力，学员还将参加一门撰写拨款的课程， 在这里，他们参与协作、积极的学习环境，以获得有关制定 NIH F31款式建议书。其他培训活动包括参加系列研讨会、参加 区域/国家科学会议，并完成传染病药物发现领域的顶峰项目 疾病。在完成这个为期一学期的顶峰项目中，学员将建立团队合作、批判性思维和 数据分析技能，同时在药物发现和传染病的背景下工作。顶石 项目将辅之以与符合以下条件的行业合作伙伴的网络和学习机会 开发治疗传染病的新药。此外，研究人员还有机会从事创业 培训，学术药物发现的一个重要方面。使用共同开发的个人发展计划， 学员和导师将根据学员的培训需求制定培训计划 职业目标。最终，培训计划将帮助学生朝着他们期望的职业目标努力， 同时还培养了一支具有独特技能的劳动力队伍，以应对发现疗法的挑战 对于传染病来说。 好了！