Harvard Systems Biology Graduate Program

项目摘要/摘要 本申请申请支持哈佛大学系统生物学博士项目。这 深刻的跨学科课程吸引了从纯数学到数学的顶尖学生 医学，并为他们提供资源和支持，以开发独立和量化的方法来 重要的生物学问题。系统生物学计划将系统生物学研究整合到 整个哈佛大学，包括哈佛主(剑桥)校区和基础科学系 哈佛医学院(HMS)及其教学医院，创造了一个真正统一的跨哈佛 鼓励学生创造性地选择研究领域和未来职业的计划。 生物系统的行为是复杂的，而且往往是不可预测的，在某种程度上，这对我们的 诊断和治疗疾病或了解我们周围世界的行为的能力。我们相信 对定量测量技术和数学或数学都有深刻理解的学生 计算方法将开发创造性的新方法来解决生物系统的复杂性。 该计划也是将量化和理论方法引入相关问题的主要工具 去诊所。 自从上一次提交这笔助学金以来，该计划在成为有代表性的学生方面取得了重大进展 人口：今年，女性科学家首次在8名女性入选队列中占据多数 2017-18年度，3000名男性和来自代表性不足的少数族裔的申请比前几年翻了一番。 达到学位的平均时间为5.4年。上一笔赠款资助了6名学员。在这一资助期内，我们 请求为8名实习生提供支持。 哈佛系统生物学博士项目是一个开创性的项目，也是一个正在进行的实验。该计划 旨在帮助学生识别跨学科方法可以提供的独特的生物问题 令人满意的答案，并为他们在未来的职业生涯中发现和解决这些问题做好准备。这个 该计划特别注重严谨性和可重复性，培养学生在物理化学基础上 他们所做的测量和适当的技术，以及统计分析中的常见陷阱。 跨学科和面向普通公众的沟通培训是该计划的基础，并且是 在每个学生的职业生涯中都受到强调。

Project Summary/abstract This application requests support for the PhD Program in Systems Biology at Harvard University. This profoundly interdisciplinary program attracts top students with backgrounds ranging from pure mathematics to medicine, and offers them the resources and support to develop an independent and quantitative approach to important biological questions. The Systems Biology program integrates systems biology research across the whole of Harvard University, including Harvard's main (Cambridge) campus and the basic science departments of Harvard Medical School (HMS) and its teaching hospitals, creating a genuinely unified cross-Harvard program that encourages student creativity and choice of both research area and of future career. The behavior of biological systems is complex and often unpredictable, in ways that profoundly challenge our ability to diagnose and treat diseases or understand the behavior of the world around us. We believe that students who have a deep understanding of both quantitative measurement technologies and mathematical or computational approaches will develop creative new ways to grapple with the complexity of biological systems. The program is also a major vehicle for bringing quantitative and theoretical approaches into problems relevant to the clinic. Since the last submission of this grant, the program has made major strides towards a representative student population: this year, for the first time, female scientists are in the majority in the entering cohort of 8 women and 3 men and applications from underrepresented minorities doubled in 2017-18 compared to previous years. The average time to degree is 5.4 years. The previous grant supported 6 trainees. In this funding period we request support for 8 trainees. The Harvard Systems Biology PhD Program is a pioneering program and an ongoing experiment. The program aims to help students identify biological questions to which an interdisciplinary approach can provide uniquely satisfying answers, and to prepare them to identify and address such questions in their future careers. The program pays particular attention to rigor and reproducibility, training students in the physicochemical basis of the measurements they make and in appropriate techniques, and common pitfalls, in statistical analysis. Training for communication across disciplines and to the lay public is foundational for the Program and is emphasized throughout each student's career.