A Spatially Resolved Molecular Atlas of Human Endothelium

人类内皮细胞的空间分辨分子图谱

• 批准号: 10197212
• 负责人: Long Cai
• 金额: $ 17.94万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-20 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197212
• 关键词: ATAC-seq; Atlases; Benchmarking; Cells; Collection; Communication; Communities; Complex; Computer software; Data; Data Collection; Data Set; Endothelium; Ensure; Exercise; Generations; Genomics; Goals; Human; Human BioMolecular Atlas Program; Instruction; Intellectual Property; Joints; Leadership; Maps; Measures; Metadata; Methods; Molecular; Mus; Organ; Phase; Policies; Procedures; Protocols documentation; Publications; Records; Reporting; Research; Research Personnel; Resolution; Role; Sampling; Schedule; Site; Standardization; System; Technology; Tissues; Travel; United States National Institutes of Health; analytical tool; body system; data access; data submission; experience; fly; meetings; open source; programs; success; transcriptome sequencing; working group

ABSTRACT - COORDINATION CORE The Coordination Core (CC) of the ​Caltech-UW Tissue Mapping Center (TMC) will be responsible for coordinating activities within our TMC, and for general administrative functions to support our TMC. It will also be responsible for tracking progress with respect to biospecimen collection and data generation, the collection and organization of metadata, ensuring appropriate QC of both biospecimens and data, and data/metadata submission to the HIVE and other appropriate portals. Finally, our CC will be responsible for ​ensuring coordination with the HuBMAP Consortium and the wider research community. The PIs of this proposal have extensive experience and track records of collaborative research, of managing complex multi-institutional projects, of successfully participating in large scale consortia in genomics (​e.g. ​ENCODE, 4DN, Centers for Mendelian Genomics), and of developing widely used open-source software and datasets (​e.g. ​Cufflinks, Monocle, cell atlases of worm, fly, mouse). We will rely on this expertise to effectively coordinate within our group as well as with the consortium and community, and to ensure that we meet all of our goals in terms of biospecimen collection, data generation, quality assessment, and data & metadata submission to the HIVE and research community to maximize the impact of this program.

摘要-协调核心 Caltech-UW组织绘图中心（TMC）的协调核心（CC）将负责 协调我们TMC内部的活动，以及支持我们TMC的一般行政职能。它还将 负责跟踪生物样本采集和数据生成的进度， 和元数据的组织，确保生物标本和数据的适当质量控制，以及数据/元数据 提交到HIVE和其他适当的门户网站。最后，我们的CC将负责确保 与HuBMAP联盟和更广泛的研究社区进行协调。该提案的PI具有 在合作研究、管理复杂的多机构合作研究方面拥有丰富的经验和良好的记录， 成功参与大型基因组学联盟的项目（例如， ENCODE，4DN，中心 孟德尔基因组学），以及开发广泛使用的开源软件和数据集（例如， 袖扣， 单眼镜，蠕虫，苍蝇，老鼠的细胞图谱）。我们将依靠这些专业知识，在我们的内部进行有效协调， 集团以及联盟和社区，并确保我们在以下方面实现所有目标： 生物标本收集、数据生成、质量评估以及向HIVE提交数据和元数据， 研究社区，以最大限度地发挥这一计划的影响。