UCSD Biomedical Scientist Career Development Program in Glycoscience

加州大学圣地亚哥分校糖科学生物医学科学家职业发展计划

• 批准号: 10197205
• 负责人: Jeffrey D Esko
• 金额: $ 105.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197205
• 关键词: Address; Advertising; Biological; Biology; California; Chemicals; Chemistry; Core Facility; Disease; Doctor of Philosophy; Exposure to; Faculty; Funding; Future; Generations; Glycobiology; Grant; Institution; International; Leadership; Life; Mentors; Mission; National Heart, Lung, and Blood Institute; National Research Council; Physicians; Play; Polysaccharides; Positioning Attribute; Process; Program Development; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Research Training; Rotation; Running; SECTM1 gene; Science; Scientist; Site; Structure; Technology; Training; United States National Institutes of Health; Universities; Visit; biological systems; biomedical scientist; career; career development; experience; interest; knowledge base; macromolecule; outreach program; professor; programs; recruit; symposium; tool; working group

PROJECT SUMMARY UCSD Biomedical Scientist Career Development Program in Glycoscience. Glycans are a vital part of all biological systems and are involved in all disease processes, but progress in understanding these key components of life has lagged far behind that of other macromolecules. Consonant with the 2012 National Research Council report “Transforming Glycoscience: A Roadmap for the Future”, efforts such as the Consortium for Functional Glycomics and the NIH Director’s Common Fund Glycoscience Initiative have sought to correct some of the technical problems, such as deficiencies in glycan synthesis, lack of tools for probing and analyzing glycans, and glycobioinformatics. The NHLBI Programs of Excellence in Glycosciences began to fill another deficiency—the lack of young investigators fluent in the concepts of glycan chemistry and biology and skilled in working with glycans. Meanwhile, the NHLBI convened a Working Group to consider mechanisms to address the still unmet need for training young scientists and physician-scientists in glycoscience, which led to this K12 Request for Applications. The leadership and faculty of the University of California (UCSD) Glycobiology Research and Training Center have played key roles in many of the above national efforts, while locally establishing coursework, the 3rd edition of Essentials of Glycobiology, core facilities and symposia that have already contributed toward excellent training in glycoscience. With 18+ years of experience, the Glycobiology Research and Training Center is uniquely positioned to respond to this request for applications with a career development program that will train a new generation of biomedical researchers versed in glycoscience. Recent graduates with MD, PhD or MD/PhD degrees will be recruited from local physician-scientist and PhD-granting programs and via national advertising to train for 2-3 years under established investigators in biomedical, biological and chemical sciences, who have a strong knowledge base regarding glycans. Run by three PIs with expertise in each of these fields, the Program will provide structured didactic and hands-on training in glycoscience through research projects relevant to the NHLBI mission. Nineteen outstanding scientists with interest in glycoscience will serve as mentors. Trainees will be exposed to currently available state-of-the-art technologies in glycan research through the GlycoAnalytics Core at UCSD, by rotation through other Consortium sites, or through short courses offered at other institutions. The UCSD Program will promote trainee diversity by active participation in national outreach programs and the existing UCSD IRACDA program. Regular networking with Visiting Professors/Advisors and participation in local, national and international symposia will round out their training. The UCSD Program will train as many 18 Scholars over the next 5 years, launching their careers as independent investigators who see glycans as integral components of their expertise, and central to their own scientific discoveries.

项目摘要 加州大学圣地亚哥分校生物医学科学家在糖科学职业发展计划。聚糖是一个重要的组成部分， 生物系统，并参与所有疾病的过程，但在了解这些关键进展 生命的组成远远落后于其他大分子。与2012年全国 研究理事会报告"转变糖科学：未来的路线图"， 功能性糖组学联盟和NIH主任共同基金糖科学倡议已经 试图纠正一些技术问题，如聚糖合成的缺陷，缺乏工具， 探测和分析聚糖和糖生物信息学。NHLBI糖科学卓越计划 开始填补另一个缺陷-缺乏精通聚糖化学概念的年轻研究人员， 生物学和熟练的工作与聚糖。同时，NHLBI召集了一个工作组， * 建立机制，以满足青年科学家和医学科学家在以下方面的培训需求： 这导致了K12的申请。该大学的领导和教师 加州（UCSD）糖生物学研究和培训中心在上述许多方面发挥了关键作用 国家的努力，同时在当地建立课程，第三版糖生物学的基本，核心 这些设施和研讨会已经为糖科学的优秀培训做出了贡献。18+年 糖生物学研究和培训中心拥有丰富的经验，能够满足这一要求 职业发展计划的应用程序，将培养新一代的生物医学研究人员 精通糖科学应届毕业生的医学博士，博士或医学博士/博士学位将从当地招聘 医生，科学家和博士授予计划，并通过国家广告培训2 - 3年， 在生物医学、生物和化学科学方面有着深厚的知识基础， 关于聚糖。该计划由三名在这些领域具有专业知识的PI运行，将提供结构化的 通过与NHLBI使命相关的研究项目，进行糖科学方面的教学和实践培训。 19位对糖科学感兴趣的杰出科学家将担任导师。学员将接触到 通过加州大学圣地亚哥分校的GlycoAnalytics核心， 通过轮流到其他联合会网站，或通过在其他机构提供的短期课程。ucsd的 该计划将通过积极参与国家推广计划和现有的 UCSD IRACDA项目。定期与客座教授/顾问建立联系， 国家和国际研讨会将为他们的培训提供补充。UCSD计划将培训多达18名 学者在未来5年，启动他们的职业生涯作为独立的调查人员谁看到聚糖作为 他们的专业知识的组成部分，并中央自己的科学发现。