UCSD Biomedical Scientist Career Development Program in Glycoscience

项目总结 加州大学圣迭戈分校血糖科学生物医学科学家职业发展计划。多聚糖是所有生物的重要组成部分 生物系统，并参与所有疾病过程，但在理解这些关键方面的进展 生命的成分远远落后于其他大分子的成分。与2012全国大赛的共鸣 研究理事会报告《糖科学转型：未来路线图》， 功能糖链联盟和NIH主任共同基金糖科学倡议 寻求纠正一些技术问题，如多糖合成方面的缺陷，缺乏用于 探测和分析多聚糖，以及糖生物信息学。NHLBI在血糖科学领域的卓越计划 开始填补另一个不足--缺乏精通多糖化学和蛋白质概念的年轻研究者 生物学的，擅长处理多聚糖的。与此同时，NHLBI召集了一个工作组来考虑 解决培训年轻科学家和内科科学家的需求仍未得到满足的机制 血糖科学，这导致了这个K12申请申请。密歇根大学的领导层和教职员工 加州大学(UCSD)糖生物学研究和培训中心在上述许多方面发挥了关键作用 国家努力，在地方建立课程作业的同时，第三版《糖生物学要领》，核心 已经为糖科学方面的出色培训做出贡献的设施和研讨会。用18年的时间 由于经验丰富，糖生物学研究和培训中心在回应这一要求方面具有独特的优势 用于职业发展计划的申请，该计划将培训新一代生物医学研究人员 精通糖科学。具有医学博士或医学博士学位的应届毕业生将从当地招聘 医生-科学家和博士授予计划和通过全国广告培训2-3年以下 在生物医学、生物和化学科学方面有经验的研究人员，他们拥有雄厚的知识基础 关于糖类。该计划由三个在这些领域都有专业知识的PI运营，该计划将提供结构化的 通过与NHLBI任务相关的研究项目进行血糖科学的教学和动手培训。 19位对糖科学感兴趣的杰出科学家将担任导师。实习生将接触到 目前通过加州大学圣迭戈分校的GlycoAnalytics核心研究糖链的最先进技术， 通过其他联盟网站轮换，或通过其他机构提供的短期课程。加州大学圣地亚哥分校 该方案将通过积极参与国家外展方案和现有的 加州大学圣迭戈分校IRACDA计划。定期与客座教授/顾问建立联系，并参与当地、 国内和国际研讨会将完善他们的培训。加州大学圣迭戈分校的项目将培训多达18名 未来5年的学者，以独立研究人员的身份开始他们的职业生涯，他们将多糖视为 这是他们专业知识的组成部分，也是他们自己科学发现的核心。

PROJECT SUMMARY UCSD Biomedical Scientist Career Development Program in Glycoscience. Glycans are a vital part of all biological systems and are involved in all disease processes, but progress in understanding these key components of life has lagged far behind that of other macromolecules. Consonant with the 2012 National Research Council report “Transforming Glycoscience: A Roadmap for the Future”, efforts such as the Consortium for Functional Glycomics and the NIH Director’s Common Fund Glycoscience Initiative have sought to correct some of the technical problems, such as deficiencies in glycan synthesis, lack of tools for probing and analyzing glycans, and glycobioinformatics. The NHLBI Programs of Excellence in Glycosciences began to fill another deficiency—the lack of young investigators fluent in the concepts of glycan chemistry and biology and skilled in working with glycans. Meanwhile, the NHLBI convened a Working Group to consider mechanisms to address the still unmet need for training young scientists and physician-scientists in glycoscience, which led to this K12 Request for Applications. The leadership and faculty of the University of California (UCSD) Glycobiology Research and Training Center have played key roles in many of the above national efforts, while locally establishing coursework, the 3rd edition of Essentials of Glycobiology, core facilities and symposia that have already contributed toward excellent training in glycoscience. With 18+ years of experience, the Glycobiology Research and Training Center is uniquely positioned to respond to this request for applications with a career development program that will train a new generation of biomedical researchers versed in glycoscience. Recent graduates with MD, PhD or MD/PhD degrees will be recruited from local physician-scientist and PhD-granting programs and via national advertising to train for 2-3 years under established investigators in biomedical, biological and chemical sciences, who have a strong knowledge base regarding glycans. Run by three PIs with expertise in each of these fields, the Program will provide structured didactic and hands-on training in glycoscience through research projects relevant to the NHLBI mission. Nineteen outstanding scientists with interest in glycoscience will serve as mentors. Trainees will be exposed to currently available state-of-the-art technologies in glycan research through the GlycoAnalytics Core at UCSD, by rotation through other Consortium sites, or through short courses offered at other institutions. The UCSD Program will promote trainee diversity by active participation in national outreach programs and the existing UCSD IRACDA program. Regular networking with Visiting Professors/Advisors and participation in local, national and international symposia will round out their training. The UCSD Program will train as many 18 Scholars over the next 5 years, launching their careers as independent investigators who see glycans as integral components of their expertise, and central to their own scientific discoveries.