UCSD Biomedical Scientist Career Development Program in Glycoscience

项目概要 加州大学圣地亚哥分校糖科学生物医学科学家职业发展计划。聚糖是一切物质的重要组成部分 生物系统并参与所有疾病过程，但在理解这些关键方面取得了进展 生命的组成部分远远落后于其他大分子。配合2012年全国 研究委员会报告“糖科学转型：未来路线图”，诸如 功能糖组学联盟和 NIH 主任共同基金糖科学计划 试图纠正一些技术问题，例如聚糖合成的缺陷、缺乏工具 探测和分析聚糖以及糖生物信息学。 NHLBI 糖科学卓越计划 开始填补另一个缺陷——缺乏精通聚糖化学概念的年轻研究人员 生物学并擅长处理聚糖。与此同时，NHLBI 召集了一个工作组来考虑 解决青年科学家和医师科学家培训需求仍未得到满足的机制 糖科学，这导致了 K12 申请请求。大学的领导和师资队伍 加州大学圣地亚哥分校（UCSD）糖生物学研究和培训中心在上述许多方面发挥了关键作用 国家努力，同时在当地建立课程作业，第三版糖生物学要点，核心 设施和研讨会已经为糖科学的优秀培训做出了贡献。拥有18年 凭借丰富的经验，糖生物学研究和培训中心具有独特的优势来满足这一要求 适用于职业发展计划的申请，该计划将培训新一代生物医学研究人员 精通糖科学。医学博士、博士或医学博士/博士学位的应届毕业生将从当地招募 医师科学家和博士学位授予计划，并通过国家广告进行 2-3 年的培训 建立了生物医学、生物和化学科学领域的研究人员，他们拥有强大的知识基础 关于聚糖。该计划由三名在每个领域具有专业知识的 PI 运行，将提供结构化的 通过与 NHLBI 使命相关的研究项目进行糖科学方面的教学和实践培训。 十九位对糖科学感兴趣的杰出科学家将担任导师。学员将接触到 目前通过加州大学圣地亚哥分校的 GlycoAnalytics Core 获得最先进的聚糖研究技术， 通过其他联盟站点轮流，或通过其他机构提供的短期课程。加州大学圣地亚哥分校 该计划将通过积极参与国家外展计划和现有的培训计划来促进学员多样性 加州大学圣地亚哥分校 IRACDA 计划。定期与客座教授/顾问建立联系并参与当地、 国家和国际研讨会将完善他们的培训。 UCSD 项目将培训多达 18 名 未来 5 年，学者们将作为独立研究人员开始他们的职业生涯，他们将聚糖视为 他们的专业知识不可或缺的组成部分，也是他们自己的科学发现的核心。

PROJECT SUMMARY UCSD Biomedical Scientist Career Development Program in Glycoscience. Glycans are a vital part of all biological systems and are involved in all disease processes, but progress in understanding these key components of life has lagged far behind that of other macromolecules. Consonant with the 2012 National Research Council report “Transforming Glycoscience: A Roadmap for the Future”, efforts such as the Consortium for Functional Glycomics and the NIH Director’s Common Fund Glycoscience Initiative have sought to correct some of the technical problems, such as deficiencies in glycan synthesis, lack of tools for probing and analyzing glycans, and glycobioinformatics. The NHLBI Programs of Excellence in Glycosciences began to fill another deficiency—the lack of young investigators fluent in the concepts of glycan chemistry and biology and skilled in working with glycans. Meanwhile, the NHLBI convened a Working Group to consider mechanisms to address the still unmet need for training young scientists and physician-scientists in glycoscience, which led to this K12 Request for Applications. The leadership and faculty of the University of California (UCSD) Glycobiology Research and Training Center have played key roles in many of the above national efforts, while locally establishing coursework, the 3rd edition of Essentials of Glycobiology, core facilities and symposia that have already contributed toward excellent training in glycoscience. With 18+ years of experience, the Glycobiology Research and Training Center is uniquely positioned to respond to this request for applications with a career development program that will train a new generation of biomedical researchers versed in glycoscience. Recent graduates with MD, PhD or MD/PhD degrees will be recruited from local physician-scientist and PhD-granting programs and via national advertising to train for 2-3 years under established investigators in biomedical, biological and chemical sciences, who have a strong knowledge base regarding glycans. Run by three PIs with expertise in each of these fields, the Program will provide structured didactic and hands-on training in glycoscience through research projects relevant to the NHLBI mission. Nineteen outstanding scientists with interest in glycoscience will serve as mentors. Trainees will be exposed to currently available state-of-the-art technologies in glycan research through the GlycoAnalytics Core at UCSD, by rotation through other Consortium sites, or through short courses offered at other institutions. The UCSD Program will promote trainee diversity by active participation in national outreach programs and the existing UCSD IRACDA program. Regular networking with Visiting Professors/Advisors and participation in local, national and international symposia will round out their training. The UCSD Program will train as many 18 Scholars over the next 5 years, launching their careers as independent investigators who see glycans as integral components of their expertise, and central to their own scientific discoveries.