U2C Administrative Core

U2C 管理核心

• 批准号: 10201602
• 负责人: Dean Paul Jones
• 金额: $ 6.28万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201602
• 关键词: Big Data; Biochemical; Cells; Chemicals; Collaborations; Communication; Communities; Complement; Data; Databases; Dedications; Development; Disease; Dissociation; Effectiveness; Environmental Health; Goals; Health; Human; Infrastructure; Ions; Knowledge; Laboratories; Lead; Leadership; Life; Maintenance; Movement; National Institute of Environmental Health Sciences; Pattern; Pharmacology; Research; Research Personnel; Resolution; Role; Sampling; Schedule; Science; Services; Structure; Support System; System; Testing; Time; Training; Universities; Work; Xenobiotic Metabolism; Xenobiotics; adduct; career development; design; environmental chemical; experience; flexibility; improved; innovation; laboratory facility; meetings; metabolomics; outreach; professor; programs; skills; success; tool; tool development; usability

Administrative Core Project Summary The Administrative Core serves critical leadership, organizational and identity roles for the Compound Identity Discovery Core (CIDC) at Emory University. Dr. Jones will serve as Core Director and maintain overall organization through regular interactions with MPIs Dr Miller, Dr Morgan and Dr Li. Dr Jones has expertise in metabolomics and long-term scientific collaborations and academic interactions with other proven scientific leaders of the Core, Dr Miller and Dr Morgan. The Core is designed to maintain a high level of flexibility for Dr Morgan's leadership in the Experimental Core to develop arrays of cell systems for targeted xenobiotic biochemical transformation while at the same time coordinating this with Dr Li's development of computational systems to support high throughput chemical identification. The Core is further designed to complement central tool development goals with activities of the Metabolomics Consortium, support service for exposome- related metabolite identification and metabolomics training and career development. Dr Miller, Director of the NIEHS-supported HERCULES Human Exposome Research Center at Emory, will be Co-Director for Exposome Outreach and Exposome Metabolite Identification. Dr Morgan will be Co-Director for Metabolomics Training and Career Development. Together, these investigators bring a high degree of organization and management experience to the Emory CIDC. The goals of the Core are to 1) Provide leadership and guidance for the Emory CIDC. The Core will work to assure that the complementary group of Emory CIDC laboratories and facilities work efficiently as a team to assure success in development of compound identification tools for xenobiotic metabolites. 2) Assure progress of the Computational Core and Experimental Core in achieving their objectives. These cores are distinct but interdependent; the Administrative Core will work to assure that the Computational Core and the Experimental Core each achieve its goals, thereby helping assure the overall success in tool development. 3) Develop an infrastructure for servicing needs of the exposome research community in identification of environmental metabolites associated with disease. The Administrative Core will work with HERCULES Human Exposome Research Center to develop a structure to support real-life testing of xenobiotic metabolite identification tools to benefit stakeholders and improve design and usability. 4) Facilitate communication between the Emory CIDC and the Metabolomics Consortium leadership, other Metabolomics Consortium components and stakeholders. The Administrative Core will serve as the primary conduit for interaction with the Metabolomics Consortium and will support additional outreach, training and career development objectives. The combined expertise and leadership skills of the Administrative Core will assure that the Emory CIDC achieves its goals to develop powerful new chemical identification tools that are scalable to identify hundreds of thousands of metabolites of environmental chemicals and other components of the human exposome.

行政核心项目摘要 行政核心为复合身份提供关键的领导、组织和身份角色 Discovery Core（CIDC），埃默里大学。琼斯博士将担任核心总监， 通过与MPIs米勒博士、摩根博士和李博士的定期交流，促进组织的发展。琼斯博士擅长于 代谢组学和长期的科学合作和学术互动与其他证明科学 内核的领导人米勒博士和摩根博士Core旨在为Dr. 摩根在实验核心中的领导地位，为靶向异生素开发细胞系统阵列， 生物化学转化，同时与李博士的计算发展相协调， 支持高通量化学鉴定的系统。核心进一步旨在补充 代谢组学联盟活动的中心工具开发目标，代谢组学的支持服务， 相关的代谢物鉴定和代谢组学培训和职业发展。米勒博士， NIEHS支持的埃默里HERCULES人类暴露体研究中心将担任 暴露体外展和暴露体代谢物鉴定。Morgan博士将担任代谢组学联合主任 培训和职业发展。这些调查人员一起带来了高度的组织性， 埃默里CIDC的管理经验。核心的目标是：1）提供领导和指导 埃默里犯罪调查中心的核心将努力确保埃默里CIDC实验室的补充小组 和设施作为一个团队有效地工作，以确保成功开发化合物鉴定工具， 异生物代谢物。2)确保计算核心和实验核心在实现 他们的目标。这些核心各不相同，但相互依存;行政核心将努力确保 计算核心和实验核心都实现了各自的目标，从而有助于确保总体 工具开发的成功。3)开发基础设施，满足棘手研究的需求 社区在识别与疾病相关的环境代谢物。行政核心将 与HERCULES人类暴露体研究中心合作，开发一种结构，以支持现实生活中的测试， 异生物质代谢物鉴定工具，使利益相关者受益，并改进设计和可用性。4)促进 埃默里CIDC和代谢组学联盟领导层之间的沟通，其他代谢组学 联合体各组成部分和利益攸关方。行政核心将作为主要渠道， 与代谢组学联盟的互动，并将支持额外的推广，培训和职业生涯 发展目标。行政核心的综合专业知识和领导技能将确保 埃默里CIDC实现了其目标，即开发可扩展的强大的新化学识别工具， 鉴定环境化学品的数十万种代谢物和环境中的其他成分， 人类的麻烦