U2C Administrative Core

行政核心项目摘要 行政核心为复合身份提供关键的领导、组织和身份角色 埃默里大学的发现核心(CIDC)。琼斯博士将担任核心总监，并保持总体 通过与MPIs米勒博士、摩根博士和李博士的定期互动，组织。琼斯博士在以下方面有专长 代谢组学和长期的科学合作以及与其他已证实的科学研究的学术互动 核心领导，米勒博士和摩根博士。核心设计旨在为灾难恢复保持高度的灵活性 摩根在实验核心领域的领导地位，为靶向异种生物开发细胞系统阵列 生化转化，同时与李博士的计算发展相协调 支持高通量化学识别的系统。核心进一步设计为补充 中心工具开发目标与代谢组学联盟的活动，支持曝光服务- 相关代谢物鉴定和代谢组学培训及职业发展。米勒博士，该中心主任 NIEHS支持的埃默里大力神人类暴露体研究中心将担任 暴露体外延及暴露体代谢物鉴定。摩根博士将担任代谢组学联席主任 培训和职业发展。这些调查人员一起带来了高度的组织性和 埃默里CIDC的管理经验。核心的目标是1)提供领导和指导 为埃默里CIDC工作。核心将努力确保埃默里CIDC实验室的补充小组 和设施作为一个团队高效地工作，以确保成功地开发用于 异源生物代谢物。2)确保计算核心和实验核心在实现方面的进展 他们的目标。这些核心是不同但相互依赖的；行政核心将努力确保 计算核心和实验核心各自实现其目标，从而有助于确保总体 在工具开发方面取得成功。3)开发基础设施以满足曝光组研究的需求 社区在识别与疾病相关的环境代谢物方面的作用。行政核心意志 与Hercules人体暴露体研究中心合作开发一种结构，以支持对 异种生物代谢物识别工具，使利益相关者受益，并改进设计和可用性。4)便利 埃默里CIDC与代谢组学联盟领导层和其他代谢组学之间的沟通 财团成员和利益相关者。行政核心将成为 与代谢组学联合会互动，并将支持更多的外联、培训和职业 发展目标。行政核心的专业知识和领导技能相结合将确保 埃默里CIDC实现了开发可扩展的强大的新化学识别工具的目标 鉴定数十万种环境化学品的代谢物和 人类曝光片。

Administrative Core Project Summary The Administrative Core serves critical leadership, organizational and identity roles for the Compound Identity Discovery Core (CIDC) at Emory University. Dr. Jones will serve as Core Director and maintain overall organization through regular interactions with MPIs Dr Miller, Dr Morgan and Dr Li. Dr Jones has expertise in metabolomics and long-term scientific collaborations and academic interactions with other proven scientific leaders of the Core, Dr Miller and Dr Morgan. The Core is designed to maintain a high level of flexibility for Dr Morgan's leadership in the Experimental Core to develop arrays of cell systems for targeted xenobiotic biochemical transformation while at the same time coordinating this with Dr Li's development of computational systems to support high throughput chemical identification. The Core is further designed to complement central tool development goals with activities of the Metabolomics Consortium, support service for exposome- related metabolite identification and metabolomics training and career development. Dr Miller, Director of the NIEHS-supported HERCULES Human Exposome Research Center at Emory, will be Co-Director for Exposome Outreach and Exposome Metabolite Identification. Dr Morgan will be Co-Director for Metabolomics Training and Career Development. Together, these investigators bring a high degree of organization and management experience to the Emory CIDC. The goals of the Core are to 1) Provide leadership and guidance for the Emory CIDC. The Core will work to assure that the complementary group of Emory CIDC laboratories and facilities work efficiently as a team to assure success in development of compound identification tools for xenobiotic metabolites. 2) Assure progress of the Computational Core and Experimental Core in achieving their objectives. These cores are distinct but interdependent; the Administrative Core will work to assure that the Computational Core and the Experimental Core each achieve its goals, thereby helping assure the overall success in tool development. 3) Develop an infrastructure for servicing needs of the exposome research community in identification of environmental metabolites associated with disease. The Administrative Core will work with HERCULES Human Exposome Research Center to develop a structure to support real-life testing of xenobiotic metabolite identification tools to benefit stakeholders and improve design and usability. 4) Facilitate communication between the Emory CIDC and the Metabolomics Consortium leadership, other Metabolomics Consortium components and stakeholders. The Administrative Core will serve as the primary conduit for interaction with the Metabolomics Consortium and will support additional outreach, training and career development objectives. The combined expertise and leadership skills of the Administrative Core will assure that the Emory CIDC achieves its goals to develop powerful new chemical identification tools that are scalable to identify hundreds of thousands of metabolites of environmental chemicals and other components of the human exposome.