Yale Clinical and Epidemiology Research in Neurology (CERN) Training Program

这是一项支持耶鲁大学神经病学临床和流行病学研究(CERN)的提案 培训计划。拟议方案的主题概念和单一重点是培训临床 神经科医生掌握临床和流行病学研究方法。耶鲁大学有一个异常强大的现有 临床神经科学研究基地。神经内科排名第9位 美国国立卫生研究院临床神经科经费最高。拥有特定专业知识的导师的关键群体 在流行病学和与神经科学相关的临床研究中，导致了 耶鲁大学的培训机会，促进了拟议项目的发展。与……订婚 这些导师将为这一新颖的研究培训提供出色的基础。我们的建议 该计划包括四个关键的神经疾病领域：脑血管疾病、神经退行性变 还有衰老、神经炎和癫痫。该计划得到了20名精心挑选的教职员工的支持 跨医学院和公共卫生学院(YSPH)。我们的目标是提供一个有密切指导的 为博士后医生科学家提供严格的研究培训计划，以获得教育和经验 拥有研究学术生涯所需的工具，专注于人类受试者研究。二 每年将挑选新的CERN培训计划研究员参加为期两年的培训计划 受过临床培训的应聘者，具有医学博士学位和以前的神经学专业培训(即神经学 派驻)。培训经验的核心将是追求一个涉及临床或 神经学中的流行病学研究。除了从事有指导的研究项目外，学员还将 完成通过YSPH提供的这些领域的核心课程，并将参加一系列 定期安排系列教学、研讨会和讲习班，以及关于负责任的行为的课程 这项研究可以通过耶鲁大学神经流行病学和临床神经学中心获得 研究中心(CNE2)和耶鲁大学临床研究中心(YCCI)。通过精心挑选的 教学和教育计划，并通过正式的指导密切监测学员的进展 过程中，学员将获得设计和执行严格的调查项目、分析其 数据，并发布他们的结果。学员将由导师和YCCI和YSPH支持的导师指导 赠款撰写讲习班，目标是成功申请独立职业发展 由奖学金结束时颁发的奖项。以研究参与者的形式拥有丰富的资源， 现有的队列和数据集、杰出的合作者和教育机会，耶鲁大学提供了 临床和流行病学神经学研究的示范环境。这将通过以下方式加以利用 这一计划旨在培养一支以病人为导向的领导调查干部队伍，共同的目标是预防 或降低与神经系统疾病相关的发病率和死亡率。

This is a proposal to support the Yale Clinical and Epidemiology Research in Neurology (CERN) Training Program. The thematic concept and single focus of the proposed program is to train clinical neurologists in clinical and epidemiological research methods. Yale has an exceptionally strong existing research base in clinical neuroscience investigation. The Department of Neurology is ranked the 9th highest clinical neurology department in NIH funding. The critical mass of mentors with specific expertise in epidemiology and clinical research relevant to the neurosciences has led to a natural expansion of the training opportunities at Yale, fostering the development of the proposed program. The engagement of these mentors will provide an outstanding foundation for this novel research training. Our proposed program encompasses four key neurologic disease areas: cerebrovascular disease, neurodegeneration and aging, neuroinflammation, and epilepsy. The program is supported by 20 carefully-selected faculty across the Schools of Medicine and Public Health (YSPH). Our objective is to provide a closely mentored rigorous research training program for postdoctoral physician scientists to gain education and experience with the tools necessary for investigative academic careers focused on human subjects research. Two new CERN Training Program fellows per year will be selected for a two-year training program from clinically trained candidates with MD degrees and prior neurological specialty training (i.e., neurology residency). Central to the training experience will be pursuit of a project involving clinical or epidemiological research in neurology. In addition to pursuing mentored research projects, trainees will complete core coursework in these areas offered through the YSPH, and will participate in a series of regularly scheduled didactic series, seminars and workshops, and a course on the responsible conduct of research, which are available through the Yale Center for Neuroepidemiology and Clinical Neurological Research (CNE2) and the Yale Center for Clinical Investigation (YCCI). Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and YCCI- and YSPH-supported grant-writing workshops, with the goal of having successfully applied for independent career development awards by the conclusion of the fellowship. With abundant resources in the form of study participants, existing cohorts and datasets, outstanding collaborators, and educational opportunities, Yale provides an exemplary environment for clinical and epidemiologic neurologic research. This will be leveraged through this program to train a cadre of leading patient-oriented investigators, with a shared goal of prevention of or reduction of morbidity and mortality associated with neurological disease.