Yale Clinical and Epidemiology Research in Neurology (CERN) Training Program

这是一项支持耶鲁大学神经病学临床和流行病学研究（CERN）的提案。 培训计划。主题概念和单一重点的拟议计划是培养临床 神经学家在临床和流行病学研究方法。耶鲁大学有着非常强大的 临床神经科学研究基地。神经内科排名第九 临床神经病学部门的最高资助。具有特定专业知识的指导者的临界质量 与神经科学相关的流行病学和临床研究导致了 在耶鲁大学的培训机会，促进拟议计划的发展。的接合 这些导师将为这一新颖的研究培训奠定良好的基础。我们提出的 该计划包括四个关键的神经系统疾病领域：脑血管疾病，神经退行性疾病， 以及衰老、神经炎症和癫痫。该计划由20名精心挑选的教师支持 医学和公共卫生学院（YSPH）。我们的目标是提供一个密切指导 为博士后医生科学家提供严格的研究培训计划，以获得教育和经验 与必要的工具，调查学术生涯的重点是人类科目的研究。两 每年新的CERN培训计划研究员将被选中参加为期两年的培训计划， 具有医学博士学位和先前神经学专业培训的临床培训候选人（即，神经病学 居住）。培训经验的核心将是追求一个涉及临床或 神经病学的流行病学研究。除了从事指导研究项目外，学员还将 完成通过YSPH提供的这些领域的核心课程，并将参加一系列 定期举办系列讲座、研讨会和讲习班，以及关于负责任地开展 耶鲁大学神经流行病学和临床神经病学中心（Yale Center for Neuroepidemiology and Clinical Neurological 研究（CNE2）和耶鲁大学临床研究中心（YCCI）。通过精心挑选的 教学和教育计划，并通过正式的指导密切监测学员的进展情况 过程中，学员将获得设计和执行严格的调查项目，分析他们的技能， 数据，并公布结果。学员将由导师指导，并得到YCCI和YSPH的支持 赠款撰写讲习班，目标是成功申请独立职业发展 奖学金的结束。以研究参与者的形式提供丰富的资源， 现有的队列和数据集，优秀的合作者和教育机会，耶鲁大学提供了一个 临床和流行病学神经病学研究的示范环境。这将通过 该计划旨在培养一批以患者为导向的主要调查人员，共同目标是预防 或降低与神经系统疾病相关的发病率和死亡率。

This is a proposal to support the Yale Clinical and Epidemiology Research in Neurology (CERN) Training Program. The thematic concept and single focus of the proposed program is to train clinical neurologists in clinical and epidemiological research methods. Yale has an exceptionally strong existing research base in clinical neuroscience investigation. The Department of Neurology is ranked the 9th highest clinical neurology department in NIH funding. The critical mass of mentors with specific expertise in epidemiology and clinical research relevant to the neurosciences has led to a natural expansion of the training opportunities at Yale, fostering the development of the proposed program. The engagement of these mentors will provide an outstanding foundation for this novel research training. Our proposed program encompasses four key neurologic disease areas: cerebrovascular disease, neurodegeneration and aging, neuroinflammation, and epilepsy. The program is supported by 20 carefully-selected faculty across the Schools of Medicine and Public Health (YSPH). Our objective is to provide a closely mentored rigorous research training program for postdoctoral physician scientists to gain education and experience with the tools necessary for investigative academic careers focused on human subjects research. Two new CERN Training Program fellows per year will be selected for a two-year training program from clinically trained candidates with MD degrees and prior neurological specialty training (i.e., neurology residency). Central to the training experience will be pursuit of a project involving clinical or epidemiological research in neurology. In addition to pursuing mentored research projects, trainees will complete core coursework in these areas offered through the YSPH, and will participate in a series of regularly scheduled didactic series, seminars and workshops, and a course on the responsible conduct of research, which are available through the Yale Center for Neuroepidemiology and Clinical Neurological Research (CNE2) and the Yale Center for Clinical Investigation (YCCI). Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and YCCI- and YSPH-supported grant-writing workshops, with the goal of having successfully applied for independent career development awards by the conclusion of the fellowship. With abundant resources in the form of study participants, existing cohorts and datasets, outstanding collaborators, and educational opportunities, Yale provides an exemplary environment for clinical and epidemiologic neurologic research. This will be leveraged through this program to train a cadre of leading patient-oriented investigators, with a shared goal of prevention of or reduction of morbidity and mortality associated with neurological disease.