Project 4: Neural Basis of Behavioral Sequences

项目 4：行为序列的神经基础

• 批准号: 10202764
• 负责人: Rachel Wilson
• 金额: $ 72.57万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202764
• 关键词: Aggressive behavior; Air; Architecture; Area; Behavior; Behavioral; Behavioral Model; Biophysics; Birds; Brain; Complex; Courtship; Cues; Drosophila genus; Electrophysiology (science); Equilibrium; Feedback; Fishes; Food; Generations; Genetic; Goals; Hunger; Image; Individual; Lead; Locomotion; Logic; Modeling; Monkeys; Motion; Motor; Neurobiology; Neurons; Organism; Partner in relationship; Probability; Recording of previous events; Resources; Sensory; Series; Shelter facility; Short-Term Memory; Signal Transduction; Sonication; Specific qualifier value; System; Testing; Theoretical Studies; Time; Vision; Walking; base; cell type; experimental study; fluidity; fly; in vivo; markov model; millisecond; mind control; neural circuit; neural network; neuromechanism; oculomotor; optogenetics; programs; relating to nervous system; theories; tool; two-photon; way finding

Project 4: Neural Basis of Behavioral Sequence Loops Abstract The goal of Project 4 is to understand how discrete action motifs are organized into goal-directed behavioral sequences that evolve over timescales of seconds to minutes. Behavioral sequence loops are at the highest level of our control-loop hierarchy, where they integrate high-level sensory representations and provide descending signals to guidance and motor loops. The execution of a behavioral sequence requires the ability to sustain activity (persistence), as well as the ability to switch between behaviors (fluidity). To investigate neural mechanisms of persistence and fluidity, we will study the circuits in the fly brain that control sequential behaviors such as visually guided walking, spatial navigation, and working memory. We will combine cell-type specific genetic driver lines with in vivo 2-photon imaging and electrophysiology to understand how these circuits balance competing demands to select and drive sequential behaviors. We will then use optogenetic tools to test specific circuit models of behavioral sequence generation in freely behaving flies. These studies are divided into the following three Specific Aims: Specific Aim 1: Defining the cellular basis of stochastic control of walking. Specific Aim 2: Identify the neural circuitry underlying path integration. Specific Aim 3: Investigate the network mechanisms of counter-turning behavior.

项目4：行为序列循环的神经基础