Project 3: Neural Basis of Motion Guidance Loops
项目 3:运动引导环的神经基础
基本信息
- 批准号:10202763
- 负责人:
- 金额:$ 49.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-30 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnimalsAugmented RealityBackBacteriaBehaviorBrainCalciumCellsChemicalsComputer ModelsCuesElectrophysiology (science)EnvironmentExhibitsEyeEye MovementsFeedbackFlying body movementFundingGeneticGoalsHeadHumanHungerHybridsImageLarvaLeadLocationMeasuresModelingMotionMotorMovementMusNeuronsOdorsOrganismOutputPlayPositioning AttributeProbabilityReflex actionRoleRunningSaccadesSensorySignal TransductionSmooth PursuitSpecific qualifier valueStimulusSystemVisualWalkingWorkbehavioral responsedesignflygenetic effectornetwork architectureneural circuitnovelprogramsrelating to nervous systemresponsesensory feedbacksensory inputvisual processingvisual stimulusvoltage
项目摘要
Project 3: The Neural Basis of Motion Guidance Loops
Abstract
The goal of Project 3 is to characterize the third level of four nested control loops, namely the Neural
Basis of Motion Guidance. Motion guidance loops operate at the intersection of sensory and motor
circuits to initiate and coordinate goal-directed behaviors. This project will dissect the circuits that
control visually guided flight, that relay signals from motor centers into the visual periphery, and that
underlie context-dependent switching of visual responses. To do this, the project will make use of
genetic driver lines to target specific neuron types, as well as genetic effector molecules that alter neural
activity and calcium dynamics. Functional outputs of the system will be measured using calcium and
voltage imaging, as well as whole-cell electrophysiological recordings of neural activity, and behavior.
Computational modeling will play central roles in both the design of visual stimuli, as well as in studies
of network architecture and behavior. These efforts are divided into the following three Aims.
Specific Aim 1: Determine the cellular basis of proportional-integral-derivative (PID)
feedback in the flight motor system.
Specific Aim 2: Determine how motor commands and hunger affect visual processing.
Specific Aim 3: Investigate the mechanisms by which odor cues can switch the direction
of visual orienting reflexes.
项目3:运动引导回路的神经基础
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas Robert Clandinin其他文献
Thomas Robert Clandinin的其他文献
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{{ truncateString('Thomas Robert Clandinin', 18)}}的其他基金
How do neurons coordinate alternative energy sources to meet the demands of computation?
神经元如何协调替代能源以满足计算需求?
- 批准号:
10606195 - 财政年份:2022
- 资助金额:
$ 49.06万 - 项目类别:
Population Neural Activity Mediating Sensory Perception Across Modalities
群体神经活动介导跨模态的感官知觉
- 批准号:
10310712 - 财政年份:2021
- 资助金额:
$ 49.06万 - 项目类别:
Population Neural Activity Mediating Sensory Perception Across Modalities
群体神经活动介导跨模态的感官知觉
- 批准号:
10242189 - 财政年份:2018
- 资助金额:
$ 49.06万 - 项目类别:
Population Neural Activity Mediating Sensory Perception Across Modalities
群体神经活动介导跨模态的感官知觉
- 批准号:
9789712 - 财政年份:2018
- 资助金额:
$ 49.06万 - 项目类别:
A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior
用于理解行为的感觉运动基础的脑回路程序
- 批准号:
10202757 - 财政年份:2017
- 资助金额:
$ 49.06万 - 项目类别:
Revealing circuit control of neuronal excitation with next-generation voltage indicators
使用下一代电压指示器揭示神经元兴奋的电路控制
- 批准号:
9380741 - 财政年份:2017
- 资助金额:
$ 49.06万 - 项目类别:
A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior
用于理解行为的感觉运动基础的脑回路程序
- 批准号:
9444301 - 财政年份:2017
- 资助金额:
$ 49.06万 - 项目类别:
A new strategy for cell-type specific gene disruption in flies and mice
果蝇和小鼠细胞类型特异性基因破坏的新策略
- 批准号:
9297370 - 财政年份:2015
- 资助金额:
$ 49.06万 - 项目类别:
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