Project 3: Neural Basis of Motion Guidance Loops

项目 3：运动引导环的神经基础

• 批准号: 10202763
• 负责人: Thomas Robert Clandinin
• 金额: $ 49.06万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202763
• 关键词: Affect; Animals; Augmented Reality; Back; Bacteria; Behavior; Brain; Calcium; Cells; Chemicals; Computer Models; Cues; Electrophysiology (science); Environment; Exhibits; Eye; Eye Movements; Feedback; Flying body movement; Funding; Genetic; Goals; Head; Human; Hunger; Hybrids; Image; Larva; Lead; Location; Measures; Modeling; Motion; Motor; Movement; Mus; Neurons; Odors; Organism; Output; Play; Positioning Attribute; Probability; Reflex action; Role; Running; Saccades; Sensory; Signal Transduction; Smooth Pursuit; Specific qualifier value; Stimulus; System; Visual; Walking; Work; behavioral response; design; fly; genetic effector; network architecture; neural circuit; novel; programs; relating to nervous system; response; sensory feedback; sensory input; visual processing; visual stimulus; voltage

Project 3: The Neural Basis of Motion Guidance Loops Abstract The goal of Project 3 is to characterize the third level of four nested control loops, namely the Neural Basis of Motion Guidance. Motion guidance loops operate at the intersection of sensory and motor circuits to initiate and coordinate goal-directed behaviors. This project will dissect the circuits that control visually guided flight, that relay signals from motor centers into the visual periphery, and that underlie context-dependent switching of visual responses. To do this, the project will make use of genetic driver lines to target specific neuron types, as well as genetic effector molecules that alter neural activity and calcium dynamics. Functional outputs of the system will be measured using calcium and voltage imaging, as well as whole-cell electrophysiological recordings of neural activity, and behavior. Computational modeling will play central roles in both the design of visual stimuli, as well as in studies of network architecture and behavior. These efforts are divided into the following three Aims. Specific Aim 1: Determine the cellular basis of proportional-integral-derivative (PID) feedback in the flight motor system. Specific Aim 2: Determine how motor commands and hunger affect visual processing. Specific Aim 3: Investigate the mechanisms by which odor cues can switch the direction of visual orienting reflexes.

项目3：运动引导回路的神经基础