Project 3: Neural Basis of Motion Guidance Loops

项目3：运动制导回路的神经基础 摘要 项目3的目标是描述四个嵌套控制循环的第三级，即神经网络 运动制导的基础。运动引导环在感觉和运动的交叉点工作 启动和协调目标导向行为的回路。这个项目将剖析 控制视觉引导飞行，将来自运动中心的信号传递到视觉外围，以及 视觉反应的上下文相关转换是基础。要做到这一点，该项目将利用 针对特定神经元类型的遗传驱动系，以及改变神经的遗传效应分子 活性和钙动力学。系统的功能输出将使用钙和 电压成像，以及神经活动和行为的全细胞电生理记录。 计算建模将在视觉刺激的设计和研究中发挥核心作用 网络架构和行为。这些努力分为以下三个目标。 具体目标1：确定比例积分导数(PID)的元胞基础 飞行马达系统中的反馈。 具体目标2：确定运动指令和饥饿是如何影响视觉处理的。 具体目标3：研究气味线索改变方向的机制 视觉定向反射。

Project 3: The Neural Basis of Motion Guidance Loops Abstract The goal of Project 3 is to characterize the third level of four nested control loops, namely the Neural Basis of Motion Guidance. Motion guidance loops operate at the intersection of sensory and motor circuits to initiate and coordinate goal-directed behaviors. This project will dissect the circuits that control visually guided flight, that relay signals from motor centers into the visual periphery, and that underlie context-dependent switching of visual responses. To do this, the project will make use of genetic driver lines to target specific neuron types, as well as genetic effector molecules that alter neural activity and calcium dynamics. Functional outputs of the system will be measured using calcium and voltage imaging, as well as whole-cell electrophysiological recordings of neural activity, and behavior. Computational modeling will play central roles in both the design of visual stimuli, as well as in studies of network architecture and behavior. These efforts are divided into the following three Aims. Specific Aim 1: Determine the cellular basis of proportional-integral-derivative (PID) feedback in the flight motor system. Specific Aim 2: Determine how motor commands and hunger affect visual processing. Specific Aim 3: Investigate the mechanisms by which odor cues can switch the direction of visual orienting reflexes.