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A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior

用于理解行为的感觉运动基础的脑回路程序

基本信息

批准号：
10202757
负责人：
Thomas Robert Clandinin
金额：
$ 281.95万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10202757
关键词：
Administrative Coordination Affect Animal Behavior Animals Attention deficit hyperactivity disorder Behavior Behavioral Biological Models Biomechanics Brain Brain region Cells Cognition Disorders Communities Computer software Cues Custom Data Analyses Data Collection Data Science Data Science Core Development Devices Diagnosis Drosophila melanogaster Electrophysiology (science)Ensure Esthesia Feedback Goals Hunger Impairment Individual Infrastructure Institution Laboratories Laboratory Research Lead Leg Link Methods Modeling Molecular Genetics Monitor Motion Motor Motor Neurons Motor output Movement Movement Disorders Muscle Nervous system structure Neurons Neurosciences Odors Pain Parkinson Disease Pattern Periodicity Process Prosthesis Protocols documentation Reflex action Research Research Project Grants Research Support Resources Role Schizophrenia Sense Organs Sensory Series Spinal Cord Spinal cord injury Standardization Stroke Structure Syndrome System Techniques United States National Institutes of Health Visual Walking Wing Work archive data archived data assistive robot attentional control base computerized tools control theory data format data science resource data sharing design executive function experience experimental study flexibility fly innovation instrument instrumentation mathematical methods meetings member motor control multidisciplinary neural circuit neuromechanism neuroregulation novel optical imaging programs recruit relating to nervous system sensory system synergism theories visual feedback visual processing

项目摘要

A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior Abstract The Project team's long-term goal is to develop a comprehensive theory of animal behavior that explicitly incorporates neural processes operating across hierarchical levels — from circuits that regulate the action of individual muscles to those that regulate behavioral sequences and decisions. Our innovative approach is guided by the notion that different brain regions are not linked within a single neuroanatomical tier, but rather constitute a series of hierarchically nested feedback loops. The effort is organized into four Research Projects, each focusing on a different processing stage related to: (1) muscle action, (2) motor patterns, (3) motion guidance, and (4) behavioral sequences. Demonstrating our commitment to team interaction, these Research Projects are not organized according to PIs laboratories, but rather each constitutes a collaborative multi- laboratory effort. The collective expertise of our research team spans the entire nervous system - from the sensory periphery to the motor periphery and was chosen to include experts in every experimental technique we require (molecular genetics, electrophysiology, optical imaging, biomechanics, quantitative behavioral analysis, control theory, and dynamic network theory). We will exploit mathematical approaches – control theory and dynamic network theory in particular – that are best suited to model feedback and the flow of information through and among different processing stages in the brain. The four complimentary and integrated Research Projects will focus on ethologically relevant natural behaviors, with an emphasis on recording methods that interrogate the functions of genetically identified neurons in intact, behaving animals – a rigorous standard that is designed to have the broadest impact on systems neuroscience. Our research exploits a single, experimentally tractable model system (Drosophila melanogaster), in which we can easily study the functions of genetically identified cell classes in ethologically relevant behaviors. Our experiments emphasize methods that interrogate the functions of neurons in intact, behaving animals, a rigorous standard that is designed to have the broadest impact on systems neuroscience. Our research will be supported by an Instrumentation and Software Resource Core that will develop and support novel devices and software, so that we can continue to employ state-of-the-art experimental techniques and data analysis. Collectively, our research program constitutes a systematic attack on the neural basis of behavior that integrates vertically across phenomenological tiers. The result of our effort will be a new synthesis of how a fully embodied brain works to generate behavior.

理解行为的感觉运动基础的脑回路程序摘要项目组的长期目标是发展一个全面的动物行为理论，结合了跨层次运作的神经过程-从调节神经元活动的电路，个体肌肉到那些调节行为序列和决定的肌肉。我们的创新方法是这一概念的指导下，不同的大脑区域不是在一个单一的神经解剖层，而是构成一系列层级嵌套的反馈回路。这项工作分为四个研究项目，每一个集中在不同的处理阶段，涉及：（1）肌肉动作，（2）运动模式，（3）运动指导;（4）行为序列。这些研究证明了我们对团队互动的承诺，项目不是根据PI实验室组织的，而是每个项目都构成了一个协作的多个实验室。实验室的努力我们研究团队的集体专业知识涵盖整个神经系统-从从感觉周边到运动周边，并选择包括每项实验技术的专家我们需要（分子遗传学，电生理学，光学成像，生物力学，定量行为学，分析、控制理论和动态网络理论）。我们将利用数学方法-控制理论和动态网络理论，特别是-最适合模型反馈和流动的信息在大脑的不同处理阶段之间传递。四个免费的，综合研究项目将侧重于动物行为学相关的自然行为，重点是在完整的、有行为的动物中询问遗传识别的神经元功能的记录方法 - 这是一个严格的标准，旨在对系统神经科学产生最广泛的影响。我们的研究利用一个单一的、实验上易于处理的模型系统（黑腹果蝇），在其中我们可以很容易地研究在行为学相关行为中基因识别的细胞类别的功能。我们的实验强调询问完整的神经元功能的方法，行为动物，严格的标准旨在对系统神经科学产生最广泛的影响。我们的研究将得到一个仪器和软件资源核心，将开发和支持新的设备和软件，我们可以继续采用最先进的实验技术和数据分析。总体而言，我们一项研究计划构成了对行为神经基础的系统性攻击，跨越现象学层面。我们努力的结果将是一个新的综合体，能产生行为

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A population of descending neurons that regulates the flight motor of Drosophila.

DOI：
10.1016/j.cub.2022.01.008
发表时间：
2022-03-14
期刊：
CURRENT BIOLOGY
影响因子：
9.2
作者：
Namiki, Shigehiro;Ros, Ivo G.;Morrow, Carmen;Rowell, William J.;Card, Gwyneth M.;Korff, Wyatt;Dickinson, Michael H.
通讯作者：
Dickinson, Michael H.

The functional organization of descending sensory-motor pathways in Drosophila.