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Imaging structure and function

影像结构与功能

基本信息

批准号：
10213733
负责人：
Thomas Robert Clandinin
金额：
$ 15.58万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213733
关键词：
Antibodies Behavioral Charge Collaborations Communities Computer software Confocal Microscopy Core Facility Custom Data Data Analyses Development Discipline Disease Electronics Equipment Faculty Goals Grant Health Hour Human Resources Image Imaging technology In Vitro Individual Investments Label Laboratories Lasers Maintenance Methods Microscope Microscopy Modality Modernization Modification Monitor Neurons Neurosciences Ophthalmology Ophthalmoscopes Optical Coherence Tomography Optics Output Ownership Photic Stimulation Play Protocols documentation Reagent Renaissance Research Research Personnel Resolution Role Scanning Scientist Services Slide Stimulus Structure Support Groups System Techniques Technology Technology Transfer Testing Time Tissues Training Ursidae Family Vision Vision research Visual Visual system structure Work adaptive optics adaptive optics scanning laser ophthalmoscopy cost data acquisition experience experimental study fluorescence microscope imaging approach imaging modality imaging system in vivo in vivo imaging innovation instrument member microscopic imaging multiphoton microscopy novel strategies optical imaging optogenetics payment process optimization recruit relating to nervous system sensor service programs software development synergism tool two-photon virtual reality environment vision development vision science visual stimulus

项目摘要

IMAGING STRUCTURE AND FUNCTION CORE SUMMARY Imaging technologies such as confocal microscopy, multiphoton microscopy and super- resolution imaging as well as optical coherence tomography have transformed the ability of scientists to observe structural and functional changes in the visual system, in vivo and ex vivo, in both health and disease. The overarching goal of the imaging core is to transform the ability of vision scientists to use these critical technologies by providing access to and training on the newest imaging modalities, and transferring novel approaches between groups to facilitate innovation in research and collaboration across vision research disciplines. This goal will be achieved through supporting (1) access to new confocal and OCT/in vivo fluorescence microscopes as well as custom adaptive optics imaging ophthalmoscopes that will be made available through the Ophthalmology Department, (2) access to advanced imaging modalities available through various Stanford Microscopy Facilities, and (3) application and dissemination of customized in vivo imaging approaches and systems developed by investigators in the vision research center.

成像结构和功能核心总结成像技术，如共焦显微镜，多光子显微镜和超分辨率成像以及光学相干断层扫描技术已经改变了科学家的能力，观察视觉系统的结构和功能变化，在体内和体外，在两个健康和疾病成像核心的首要目标是改变视觉科学家的能力，通过提供最新成像模式的使用和培训来使用这些关键技术，并在小组之间转移新的方法，以促进研究和合作的创新跨视觉研究学科。这一目标将通过以下方式实现：（1）提供新的共聚焦和OCT/体内荧光显微镜以及定制自适应光学成像眼科将提供的检眼镜，（2）获得通过各种斯坦福大学显微镜设施提供的先进成像模式，以及（3）应用和传播定制的体内成像方法和系统，视觉研究中心的研究人员。