West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

西弗吉尼亚临床和转化科学研究所：通过合作伙伴关系和变革性研究改善健康

• 批准号: 10210187
• 负责人: Sally Lynn Hodder
• 金额: $ 157.32万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10210187
• 关键词: 2019-nCoV; Address; African American; Agreement; Area; Automobile Driving; Award; COVID-19; COVID-19 pandemic; Case Study; Center for Translational Science Activities; Cessation of life; China; Clinical; Clinical Research; Clinical Sciences; Collaborations; Color; Country; Data; Delaware; Development; Disease; Disease Outbreaks; Electronic Health Record; Ensure; Funding; Goals; Health; Human Resources; Hypertension; Infection; Institutes; Institutional Review Boards; Leadership; Louisiana; Maine; Meat; Mississippi; Morbidity - disease rate; Native Americans; Nebraska; New England; New York City; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oklahoma; Outcome; Patient-Focused Outcomes; Patients; Persons; Plants; Population; Population Heterogeneity; Prisons; Request for Applications; Research; Research Personnel; Resources; Rhode Island; Rural; Rural Population; Site; Specific qualifier value; Testing; Translational Research; Translations; Underserved Population; United States; Vulnerable Populations; West Virginia; Work; base; cohort; comorbidity; coronavirus disease; data exchange; data format; data resource; data to knowledge; diverse data; health care service organization; human disease; improved; medically underserved population; mortality; novel coronavirus; operation; pandemic disease; programs; respiratory; rural area; urban area

Emergence of a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has resulted in human disease (COVID-19) that has swept the globe in pandemic proportions with more than eight million confirmed cases and >440,000 deaths to date. Surges of COVID-19 have occurred throughout the United States (US) with urban centers such as New York City and New Orleans hardest hit. COVID-19 clinical descriptions have evolved from what was initially felt to be a respiratory illness to a multisystem disease with protean manifestations. Moreover, disparities in outcomes have been described with African Americans having higher infection and mortality rates. Populations residing in rural areas are often poorer, older, and have multiple co-morbidities such as type 2 diabetes, obesity and hypertension, raising questions about disease manifestations and outcomes that may differ from those described in urban areas. COVID-19 cases and mortality in rural areas continues to climb with multiple outbreaks, many of which have been related to meat packing plants and prison clusters. The National COVID Cohort Collaborative (N3C) has been established by the National Center for Data to Health (CD2H) in partnership with the National Center for Advancing Translational Sciences (NCATS) for purposes of building a centralized national data resource for the study of COVID-19. As N3C will facilitate translation of data into knowledge urgently needed to effectively address the COVID-19 pandemic, it is critically important that this resource contain patient outcomes data from diverse populations throughout the US – both urban and rural – with inclusion of populations of color, Native Americans, and others. The Institutional Development Award Program Clinical Translational Research Centers (IDeA CTRs) are located in diverse areas of the US, serving rural populations as well as other vulnerable groups, including Native Americans and persons of color. IDeA CTRs are well poised to provide outcomes data that relate to a diverse group of medically underserved persons that may otherwise not receive adequate representation in the N3C. Specifically, eight IDeA CTRs located in Delaware, Louisiana, Maine, Mississippi, Nebraska, Oklahoma, Rhode Island, and West Virginia have established relationships with healthcare organizations that have, to date, have conducted SARS CoV-2 testing among more than 285,000 persons, of whom more than 25,000 have tested positive. This project will enable rapid contribution of COVID-19 patient data from IDeA states to N3C, enhancing understanding of COVID-19 in the US and driving further research addressing COVID-19 patient outcomes in multiple underserved populations.

出现一种新型冠状病毒，现称为严重急性呼吸系统综合征冠状病毒 2（SARS CoV-2），导致了人类疾病（COVID-19），席卷了地球仪， 大流行的比例，迄今为止确诊病例超过800万例，死亡人数超过44万。 COVID-19疫情在美国各地激增，城市中心如 纽约市和新奥尔良受灾最严重。2019冠状病毒病的临床描述已经演变 从最初认为的呼吸系统疾病到多系统疾病， 表现。此外，在非裔美国人中， 感染率和死亡率更高。居住在农村地区的人口往往比较贫穷， 老年人，并有多种合并症，如2型糖尿病，肥胖和高血压，提高 关于疾病表现和结局的问题，可能与 市区农村地区的COVID-19病例和死亡率继续攀升， 爆发，其中许多与肉类加工厂和监狱集群有关。的 国家数据中心成立了国家COVID队列协作（N3 C） 与国家推进转化科学中心合作， （NCATS），旨在为COVID-19研究建立集中的国家数据资源。 由于N3 C将促进将数据转化为有效解决全球气候变化问题所迫切需要的知识， COVID-19大流行，此资源包含患者结局数据至关重要 来自美国各地的不同人群-城市和农村-包括人口 有色人种、美洲原住民和其他人。机构发展奖计划临床 转化研究中心（IDEA CTR）位于美国的不同地区，为农村地区提供服务。 这是一个非常重要的问题，因为它涉及到人口以及其他弱势群体，包括美洲原住民和有色人种。 IDEA CTR已做好充分准备，可提供与不同医学组相关的结局数据 服务不足的人，否则可能无法在N3 C中获得足够的代表性。 具体而言，位于特拉华州、路易斯安那州、缅因州、密西西比、内布拉斯加州、 俄克拉荷马州、罗得岛和西弗吉尼亚州已经与医疗保健建立了关系 迄今为止，已经在285，000多名患者中进行了SARS CoV-2检测的组织 其中25 000多人检测呈阳性。该项目将使快速 将来自IDEA州的COVID-19患者数据贡献给N3 C， 美国的COVID-19，并推动进一步研究解决美国的COVID-19患者结局 多个服务不足的人群。