West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

自新型冠状病毒(SARS-CoV-2)在美国出现以来，超过33 已确诊病例100万例，死亡人数已攀升至60多万人。这个 机构发展奖计划(IDEA)临床和转化研究中心 (CTR)位于美国的不同地区，服务于农村人口和其他 服务不足的群体，包括美洲原住民、西班牙裔个人和有色人种。 许多接受IDEA-CTR服务的州都是受新冠肺炎影响最严重的州之一 大流行。国家COVID队列协作(N3C)已由国家 数据到健康中心(CD2H)与国家推进中心合作 翻译科学(NCATS)作为COVID研究的集中国家数据资源-- 19.在过去的一年里，参加国家COVID队列合作的8个IDEA-CTR (N3C)提供了超过175,000人的电子健康记录(EHR)数据 感染了SARS-COV-2。IDEA-CTR调查人员曾领导多个N3C域名团队， 参与了许多数据项目，并聘请了150多名IDEA州调查人员 美国。此外，N3C已经作为一种刺激，推动了CTR作为一个高度 协作网络。IDEA CTR现在已经做好了充分准备，可以在此经验基础上实现 纳入来自美国其他地区的EHR，扩大不同领域的参与 研究人员贯穿整个IDEA州，最重要的是，推动与少数群体相关的科学 以及服务不足的想法国家人口，并将结果传达给这些社区。我们 将通过以下目标实现这些广泛目标：目标1-建立想法-CTR 基础设施，以组织创意CTR之间的协作，以推动相关 科学；目标2-扩大IDEA-CTR数据对N3C的贡献，从而增加代表性 N3C数据集中的少数民族、农村和其他未得到充分服务的人口；目标3-提供 使用一系列技术进行尖端大数据研究所需的分析支持， 包括机器学习(ML)和人工智能(AI)，以回答重要研究 关于SARS-CoV-2病毒在理想状态下的影响的问题；和目标4--积极参与 IDEA州的调查人员将能够进行高质量的新冠肺炎数据项目(通过 N3C)与各自州的人口有关，同时促进调查员的发展。

Since the emergence of the novel coronavirus (SARS-Cov-2) in the United States, more than 33 million cases have been confirmed, and the death toll has climbed to over 600,000 persons. The Institutional Development Award Program (IDeA) Clinical and Translational Research Centers (CTRs) are located in diverse areas of the US, serving rural populations as well as other underserved groups, including Native Americans, Hispanic individuals, and persons of color. Many states served by IDeA-CTRs have been among those hardest hit by the COVID-19 pandemic. The National COVID Cohort Collaborative (N3C) has been established by the National Center for Data to Health (CD2H) in partnership with the National Center for Advancing Translational Sciences (NCATS) as a centralized national data resource for the study of COVID- 19. Over the past year, the 8 IDeA-CTRs participating in National COVID Cohort Collaborative (N3C) have contributed electronic health record (EHR) data on more than 175,000 individuals infected with SARS-COV-2. IDeA-CTR investigators have led multiple N3C Domain Teams, participated in many data projects, and engaged more than 150 IDeA state investigators across the US. Moreover, N3C has served as a stimulus for the IDeA CTRs to work as a highly collaborative network. IDeA CTRs are now well poised to build on this experience to enable inclusion of EHRs from additional areas of the United States, broaden engagement of diverse investigators throughout IDeA states, and most importantly, to drive science relevant to minority and underserved IDeA state populations with communication of results to those communities. We will accomplish these broad objectives through the following aims: Aim 1 - Build IDeA-CTR infrastructure to organize collaboration among IDeA CTRs for purposes of driving relevant science; AIM 2 - Expand IDeA-CTR data contributions to N3C, thereby, increasing representation of minority, rural, and other underserved populations in the N3C dataset; Aim 3 - Provide the necessary analytic support to conduct cutting-edge big data research using a range of techniques, including machine learning (ML) and artificial intelligence (AI), to answer important research questions regarding impact of SARS-CoV-2 in IDeA states; and Aim 4 - Actively engage investigators in IDeA states to enable conduct of high quality COVID-19 data projects (through N3C) relevant to populations in their respective states while facilitating investigator development.