West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

近年来，阿巴拉契亚地区的死亡率逐渐上升，而死亡率却在下降。 在美国其他地区观察到的利率。西弗吉尼亚州在全国50个州中排名第47位。 2015年美国健康排行榜。此外，WV仍处于或接近一些慢性疾病的底部 癌症和心血管疾病等疾病。仅靠这些观察并不能全面反映 国家或地区与健康有关的挑战的连续性，但明确强调需要继续关注 以及对支撑真正解决方案的研究的投资。西弗吉尼亚临床与翻译 科学研究所(WVCTSI)成立于2012年，通过最初的临床和转化研究(CTR) 并随后形成了一个联系良好的全州研究网络，创建了基础设施 以解决西弗吉尼亚州存在的巨大健康差距。WVCTSI的首要目标是 作为协作中心，引领全州范围内的临床和转化研究创新，催化和 加快开发解决令人头疼的健康问题的解决方案。在过去的四年里，WVCTSI一直是 变革力量，实施调查员指导服务，建立试点项目资金，形成 以实践为基础的研究网络，由68个地点(大部分是农村地区)组成，创建了一个200万个的综合数据存储库 独特的电子病历，发展一种基础广泛的研究诚信文化，并与我们的 合作伙伴建立信任和有效协作。WVCTSI现在处于有利地位，可以实现这一目标 续签申请，包括：1)建立可持续的研究基础设施，对 到2022年改善世界卫生组织的健康结果，2)招募下一代临床医生科学家和翻译 在团队科学方面表现出色并为长期成功做好准备的研究人员，以及3)积极参与 多个利益相关者，包括社区、医疗提供者和政策制定者，以推动研究 改善西弗吉尼亚人的健康。我们的合作伙伴还包括该州所有的学术医疗中心 作为肯塔基大学、退伍军人管理局和国家职业安全研究所 和健康。通过其集体活动和强大的伙伴关系，WVCTSI将在以下方面发挥关键作用 扭转西弗吉尼亚州死亡率上升的趋势，为制定有效的 为区域卫生问题提供解决方案的研究基础设施。

Mortality rates in Appalachia have progressively increased over recent years, in contrast to decreasing mortality rates observed in the remainder of the US. West Virginia was ranked 47th overall among the 50 states in the 2015 America's Health Rankings. In addition, WV remains at, or near, the bottom for a number of chronic diseases including cancer and cardiovascular disease. These observations alone do not capture the entire continuum of health related challenges in the state or region, but clearly emphasize the need for continued focus on, and investment in, research that underpins real solutions. The West Virginia Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Clinical and Translational Research (CTR) award and has subsequently formed a well-connected, statewide research network, creating the infrastructure to address the substantial health disparities that exist in West Virginia. The overarching goal of the WVCTSI is to serve as a collaborative hub to lead statewide innovation in clinical and translational research, catalyzing and accelerating development of solutions to vexing health problems. Over the past four years, WVCTSI has been a transformative force, implementing investigator mentoring services, establishing pilot project funding, forming a practice-based research network of 68 sites (mostly rural), creating an integrated data repository of two million unique electronic medical records, developing a broad-based culture of research integrity, and working with our partners to establish trust and effective collaboration. WVCTSI is now well positioned to attain the goals of this renewal application that include: 1) building sustainable research infrastructure that substantively contributes to improving WV health outcomes by 2022, 2) recruiting the next generation of clinician scientists and translational researchers that excel in team science and are positioned for long-term success, and 3) actively engaging with multiple stakeholders that include communities, medical providers, and policy makers to drive research that improves health of West Virginians. Our partners include all academic medical centers within the state as well as the University of Kentucky, the Veterans Administration, and the National Institute for Occupational Safety and Health. Through its collective activities and powerful partnerships, the WVCTSI will play a critical role in reversing the trend of increasing mortality rates in West Virginia and serve as a model for developing effective research infrastructure that provides solutions to regional health issues.