Health Effects and Geochemistry of Arsenic

砷的健康影响和地球化学

• 批准号: 10203196
• 负责人: Ana Navas-Acien
• 金额: $ 1.08万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203196
• 关键词: 10 year old; Academia; Address; Adult; Affect; Area; Arsenic; Bangladesh; Blood; Carbon; Cardiovascular Diseases; Child; China; Chronic; Cods; Cohort Studies; Communication; Communities; Consult; Consultations; Core Facility; Country; Data; Data Set; Development; Diabetes Mellitus; Diet; Diffuse; Disease Outcome; Dose; Ecology; Elements; Engineering; Environment; Exposure to; Folic Acid; Food; Food Contamination; Fostering; Geography; Geological Survey; Geoscience; Government; Government Agencies; Health; Household; Human; In Situ; Incentives; Incidence; Individual; Information Dissemination; Inner Mongolia; Intake; Intelligence; Laboratories; Local Government; Longitudinal Studies; Longitudinal cohort study; Lung diseases; Maine; Mentors; Meta-Analysis; Metabolism; Methylation; Minnesota; Mission; New Jersey; Non-Malignant; Nongovernmental Organizations; Outcome; Politics; Positioning Attribute; Postdoctoral Fellow; Precipitation; Privatization; Production; Prospective cohort study; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Research; Research Project Grants; Rice; Scientist; Series; Signal Recognition Particle; Site; Soil; Source; State Government; Subgroup; Superfund; Supplementation; Taiwan; Technology; Technology Transfer; Testing; Toxic effect; Training; Translational Research; United States; Universities; Vitamin B Complex; Water; adverse outcome; anthropogenesis; base; cognitive ability; contaminated water; drinking water; experimental study; exposed human population; graduate student; ground water; health data; improved; iron oxide; magnetite ferrosoferric oxide; methyl group; next generation; novel; novel strategies; outreach; programs; remediation; response; skills; social; study population; success; superfund site; trial comparing; undergraduate student; well water

Overall - Project Summary/Abstract: The contamination of water and aquifer sediments with arsenic (As) is associated with major public health and environmental mitigation issues in the United States. At present, 823 of 1739 U.S. Superfund sites list As as a major contaminant; in addition millions of U.S. residents are unduly exposed due to naturally occurring As in their household well water. This proposal includes two biomedical and two geoscience projects that seek to address critically important issues that collectively aim to reduce As exposure and toxicity in exposed human populations in the U.S. and in Bangladesh, where much information can be learned that will benefit residents of the U.S. and elsewhere. The proposal builds on the strengths of our existing longitudinal cohort study of 35,000 adults in Bangladesh by examining dose-response relationships between As exposure (in the low-mid range) from contaminated food and water with incident cases (and sub-types) of cardiovascular disease (CVD) and non-malignant lung disease, as well as diabetes mellitus (DM). In addition, we will combine and meta-analyze data from Bangladesh, Taiwan, China (Inner Mongolia) and the U.S. (AZ, CO, ND, OK, SD) to refine the dose-response relationships between As exposure and CVD. We build off our previous observations that: a) As exposure is associated with deficits in child intelligence; and b) that folate, a B vitamin, facilitates As metabolism and elimination in adults. We propose to conduct a randomized clinical trial in 8-10 year old children in Bangladesh to test the hypothesis that folate+B12 supplementation can: a) lower blood As; and b) improve cognitive abilities in children. Building on our previous geoscience research which indicates that in situ magnetite formation forms a diffuse barrier capable of long-term As retention, we propose to conduct laboratory and field research to optimize and implement this new approach at a U.S. Geological Survey research site on Cape Cod, MA and a Superfund site in Raleigh, NC. In Bangladesh, we will quantify the geographic and socio-political barriers to reducing As exposure by analyzing the vast data sets accumulated in our main study area and we will conduct a randomized controlled trial comparing ways to overcome some of them. In parallel, we will continue to examine the potential vulnerability to human perturbations of shallow and deep aquifers that are low in As. These low As aquifers are crucial for reducing exposure to our study population and the country at large. In the U.S., we will build on our proven success of partnering with state and local governments to reduce As exposure in communities that rely on As-contaminated household wells in ME, NJ and MN. We will also continue to facilitate effective communication among our SRP scientists, stakeholders and government partners via five specific strategies. Finally, we will continue to train the next generation of scientists with disciplinary and inter-disciplinary skills that will enable them to improve the health of those who reside in environments that might expose them to As and other contaminants in soil, water and food.

总体 - 项目摘要/摘要：砷 (As) 对水和含水层沉积物的污染 与美国重大公共卫生和环境缓解问题相关。目前，823 1739 个美国超级基金站点中的 1739 个将 As 列为主要污染物；此外，数百万美国居民过度 由于家庭井水中自然存在的砷而暴露。该提案包括两项生物医学 以及两个地球科学项目，旨在解决至关重要的问题，共同旨在减少砷 美国和孟加拉国的暴露人群的暴露和毒性，有很多信息 据了解，这将使美国和其他地方的居民受益。该提案建立在以下优势之上： 我们现有的纵向队列研究通过检查剂量反应对孟加拉国 35,000 名成年人进行 受污染食品和水的砷暴露（中低范围）与事故之间的关系 心血管疾病 (CVD) 和非恶性肺病以及糖尿病的病例（和亚型） 梅利图斯（DM）。此外，我们还将结合来自孟加拉国、台湾、中国（内陆）的数据并进行荟萃分析。 蒙古）和美国（AZ、CO、ND、OK、SD）完善砷暴露之间的剂量反应关系 和化学气相沉积。我们根据之前的观察发现：a) 由于暴露与儿童的缺陷有关 智力; b) 叶酸（一种 B 族维生素）可促进成人的 As 代谢和消除。我们建议 在孟加拉国对 8-10 岁儿童进行了一项随机临床试验，以检验叶酸+B12 的假设 补充可以： a) 降低血砷； b) 提高​​儿童的认知能力。 基于我们之前的地球科学研究表明，原位磁铁矿形成形成了 由于扩散屏障能够长期保留，我们建议进行实验室和现场研究 在位于马萨诸塞州科德角的美国地质调查局研究基地和一个 位于北卡罗来纳州罗利的超级基金网站。在孟加拉国，我们将量化地理和社会政治障碍 通过分析我们主要研究领域积累的大量数据集来减少砷暴露，我们将进行 一项随机对照试验，比较克服其中一些问题的方法。与此同时，我们将继续 研究砷含量低的浅层和深层含水层对人类干扰的潜在脆弱性。 这些低砷含水层对于减少我们的研究人群和整个国家的暴露至关重要。 在美国，我们将在与州和地方政府合作的成功经验基础上再接再厉， 减少缅因州、新泽西州和明尼苏达州依赖砷污染家庭水井的社区的砷暴露。我们将 还继续促进我们的 SRP 科学家、利益相关者和政府之间的有效沟通 合作伙伴通过五项具体战略。最后，我们将继续培养下一代科学家 学科和跨学科技能，使他们能够改善居住在该地区的人们的健康 可能使他们接触土壤、水和食物中的砷和其他污染物的环境。

项目成果

Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain.

• DOI: 10.1016/j.envpol.2018.01.008
• 发表时间: 2018-04
• 期刊: Environmental pollution (Barking, Essex : 1987)
• 作者: Grau-Perez M;Navas-Acien A;Galan-Chilet I;Briongos-Figuero LS;Morchon-Simon D;Bermudez JD;Crainiceanu CM;de Marco G;Rentero-Garrido P;Garcia-Barrera T;Gomez-Ariza JL;Casasnovas JA;Martin-Escudero JC;Redon J;Chaves FJ;Tellez-Plaza M
• 通讯作者: Tellez-Plaza M

Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh.

• DOI: 10.1289/ehp.1001937
• 发表时间: 2011-01
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Pilsner JR;Hall MN;Liu X;Ahsan H;Ilievski V;Slavkovich V;Levy D;Factor-Litvak P;Graziano JH;Gamble MV
• 通讯作者: Gamble MV

Megacity pumping and preferential flow threaten groundwater quality.

• DOI: 10.1038/ncomms12833
• 发表时间: 2016-09-27
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Khan, Mahfuzur R.;Koneshloo, Mohammad;Knappett, Peter S. K.;Ahmed, Kazi M.;Bostick, Benjamin C.;Mailloux, Brian J.;Mozumder, Rajib H.;Zahid, Anwar;Harvey, Charles F.;van Geen, Alexander;Michael, Holly A.
• 通讯作者: Michael, Holly A.

Urinary and dietary analysis of 18,470 bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity.

• DOI: 10.1371/journal.pone.0080691
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Melkonian S;Argos M;Hall MN;Chen Y;Parvez F;Pierce B;Cao H;Aschebrook-Kilfoy B;Ahmed A;Islam T;Slavcovich V;Gamble M;Haris PI;Graziano JH;Ahsan H
• 通讯作者: Ahsan H

Epigenetic Biomarkers of Lead Exposure and Cardiovascular Disease: Prospective Evidence in the Strong Heart Study.

• DOI: 10.1161/jaha.122.026934
• 发表时间: 2022-12-06
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Lieberman-Cribbin W;Domingo-Relloso A;Navas-Acien A;Cole S;Haack K;Umans J;Tellez-Plaza M;Colicino E;Baccarelli AA;Gao X;Kupsco A
• 通讯作者: Kupsco A