Morphological and Biomechanical Insights into the Pathophysiology of Femoroacetabular Impingement Syndrome
股髋臼撞击综合征病理生理学的形态学和生物力学见解
基本信息
- 批准号:10207471
- 负责人:
- 金额:$ 47.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AnatomyAnimal ModelArthrographyArticular Range of MotionArticulationBiomechanicsCartilageClinicalComputational TechniqueConflict (Psychology)Control GroupsDataDeformityDegenerative polyarthritisDevelopmentDiagnosisDiagnostic radiologic examinationDiseaseElementsEtiologyEvaluationExhibitsFilmFinite Element AnalysisFluoroscopyFunctional disorderGrowthHeadHigh PrevalenceHip JointHip OsteoarthritisHip region structureImageIndividualInjuryIntuitionJointsLeadLeftLocationMagnetic ResonanceMeasurementMeasuresMechanicsMethodsModelingMorphologyMotionNeckOperative Surgical ProceduresOutcomePainPathogenesisPathologicPatientsPopulationPositioning AttributeProceduresReplacement ArthroplastyReportingResearchResource SharingScanningShapesStressStructureSymptomsSyndromeTechniquesTechnologyTractionTranslationsWalkingagedbonecohortdesignexperiencegait rehabilitationimprovedin silicoin vivoinnovationinsightkinematicsnovel strategiesosteochondral tissuepain reliefpathomechanicsshear stresssuccesstheoriestreatment strategyyoung adult
项目摘要
PROJECT SUMMARY
By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis
(OA) cases. FAIS patients present with a loss of sphericity of the femoral head, reduction in femoral-neck offset,
and/or an excessively prominent acetabular wall. Patients report pain that is position- or motion-related. Often,
cartilage is delaminated from bone and the labrum is torn. The theory of FAIS pathophysiology is that
pathoanatomy causes pathomechanics. However, we lack a quantitative understanding of the disease. Studies
that have examined hip anatomy and biomechanics in FAIS patients have yielded conflicting data, likely due to
the application of inaccurate measurement techniques. There is also a high prevalence of FAI morphology
among the asymptomatic population (i.e., positive controls), which has hindered progress to understand why FAI
morphology causes damage. Herein, we apply experimental and computational techniques to advance
understanding of FAIS pathophysiology. We will examine three cohorts: FAIS patients, negative controls, and
positive controls. Aim 1 will measure in-vivo hip articulation during inclined walking, pivoting, and squatting in the
three cohorts using dual fluoroscopy. We hypothesize that patients with FAIS will exhibit altered kinematics;
however, given our preliminary data, we posit that range of motion will not be reduced in patients. Further, we
hypothesize that positive controls will have altered kinematics when compared to negative controls. In Sub-Aim
1, we will visualize the interaction between the shape of the hip joint and its kinematic position during dynamic
loading using statistical shape modeling of the dual fluoroscopy data. Completion of Aim 1 improve clinical
understanding of FAIS by enabling us to visualize the effects of pathologic shape during dynamic loading. Aim
2 will analyze chondrolabral mechanics in-silico to improve understanding of FAIS pathophysiology. Specifically,
we will generate finite element models of bone, cartilage, and labrum using a validated pipeline. We will compare
load transfer to the labrum and shear stresses and strains at the osteochondral and chondrolabral junction during
inclined walking, pivoting, and squatting. We hypothesize that load transfer to the labrum is increased, and
cartilage shear stresses and strains at the osteochondral and chondrolabral junctions are elevated in FAIS
patients. Compensatory motion experienced by the positive control group may keep chondrolabral stresses and
strains within normal. Thus, we hypothesize that there will be no significant differences in FE results between
the two control groups. Sub-Aim 2 will quantify relationships between local measures of hip shape and
chondrolabral mechanics. Completion of Aim 2 will enhance understanding of OA pathogenesis in patients with
FAIS. Identifying how positive controls cope with their deformities could inform new treatment strategies.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Andrew Edward Anderson其他文献
Andrew Edward Anderson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Andrew Edward Anderson', 18)}}的其他基金
Morphologic and Kinematic Adaptations of the Subtalar Joint after Ankle Fusion Surgery in Patients with Varus-type Ankle Osteoarthritis
内翻型踝骨关节炎患者踝关节融合手术后距下关节的形态和运动学适应
- 批准号:
10725811 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Morphological and Biomechanical Insights into the Pathophysiology of Femoroacetabular Impingement Syndrome
股髋臼撞击综合征病理生理学的形态学和生物力学见解
- 批准号:
10437851 - 财政年份:2020
- 资助金额:
$ 47.94万 - 项目类别:
Morphological and Biomechanical Insights into the Pathophysiology of Femoroacetabular Impingement Syndrome
股髋臼撞击综合征病理生理学的形态学和生物力学见解
- 批准号:
10032655 - 财政年份:2020
- 资助金额:
$ 47.94万 - 项目类别:
Quantifying the Pathophysiology of Femoroacetabular Impingement Syndrome
量化股髋臼撞击综合征的病理生理学
- 批准号:
9985290 - 财政年份:2019
- 资助金额:
$ 47.94万 - 项目类别:
Population-Based Shape and Biomechanical Analysis of Hip Pathoanatomy
基于人群的髋关节病理解剖形状和生物力学分析
- 批准号:
8892826 - 财政年份:2013
- 资助金额:
$ 47.94万 - 项目类别:
Computational and Statistical Framework to Model Tissue Shape and Mechanics
组织形状和力学建模的计算和统计框架
- 批准号:
10612478 - 财政年份:2013
- 资助金额:
$ 47.94万 - 项目类别:
Population-Based Shape and Biomechanical Analysis of Hip Pathoanatomy
基于人群的髋关节病理解剖形状和生物力学分析
- 批准号:
9113003 - 财政年份:2013
- 资助金额:
$ 47.94万 - 项目类别:
Musculoskeletal and Finite Element Modeling of Femoroacetabular Impingement
股骨髋臼撞击的肌肉骨骼和有限元建模
- 批准号:
8629695 - 财政年份:2013
- 资助金额:
$ 47.94万 - 项目类别:
Population-Based Shape and Biomechanical Analysis of Hip Pathoanatomy
基于人群的髋关节病理解剖形状和生物力学分析
- 批准号:
8595484 - 财政年份:2013
- 资助金额:
$ 47.94万 - 项目类别:
Computational and Statistical Framework to Model Tissue Shape and Mechanics
组织形状和力学建模的计算和统计框架
- 批准号:
10471785 - 财政年份:2013
- 资助金额:
$ 47.94万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 47.94万 - 项目类别:
Grant-in-Aid for Early-Career Scientists