Musculoskeletal and Finite Element Modeling of Femoroacetabular Impingement

股骨髋臼撞击的肌肉骨骼和有限元建模

• 批准号: 8629695
• 负责人: Andrew Edward Anderson
• 金额: $ 15.83万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8629695
• 关键词: Activities of Daily Living; Agreement; Area; Arthrography; Articular Range of Motion; Biomechanics; Cadaver; Cartilage; Clinical; Computer Simulation; Consensus; Data; Degenerative polyarthritis; Development; Diagnosis; Elements; Equipment; Etiology; Evaluation; Fluoroscopy; Foundations; Funding; Geometry; Goals; Head; Hip Joint; Hip Osteoarthritis; Hip Pain; Hip region structure; Human; In Vitro; Investigation; Joints; Lead; Life; Link; Literature; Location; Lower Extremity; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medical Imaging; Methods; Modeling; Morphology; Motion; Motivation; Muscle; Musculoskeletal; Operative Surgical Procedures; Outcome; Pathology; Patients; Protocols documentation; Reaction; Research; Resolution; Rotation; Sampling; Site; Skin; Speed; Staging; Stress; Surface; Testing; Thick; Validation; acetabulum; articular cartilage; base; bone geometry; computer studies; improved; in vivo; instrument; kinematics; public health relevance; research study; treatment strategy; young adult

DESCRIPTION (provided by applicant): Femoroacetabular impingement (FAI) is a reduction in hip joint clearance that causes hip pain and may predispose the hip joint to osteoarthritis (OA). Altered biomechanics are considered the key initiator of OA. Patients with FAI often present with chondrolabral damage and restrictions in range of motion, suggesting that FAI alters cartilage/labrum contact mechanics and hip kinematics. Recent studies suggest that FAI may also cause primary or adaptive changes to muscle activation and force. Previous clinical and basic biomechanics studies have failed to elucidate the link between FAI, altered biomechanics and OA due to oversimplified approaches or inaccurate testing equipment. Our long term goal is to improve the diagnosis and treatment of FAI by quantifying hip biomechanics. To support this goal, we propose a R21-level research study to demonstrate the feasibility of using a combined experimental and computational protocol to quantify joint kinematics, muscle forces/activations, and cartilage/labrum contact mechanics in the human hip. We will use a combination of dual fluoroscopy and camera-based marker tracking to quantify lower limb kinematics during activities of daily living. Musculoskeletal (MS) models will estimate muscle forces/activations and finite element (FE) models will predict chondrolabral mechanics. In the past, our MS models assumed a static hip joint center and pre-defined muscle attachments and our FE models assumed boundary and loading conditions from the literature. In this R21, we will compare MS model (Aim 1) and FE model (Aim 2) predictions between models that are subject-specific with those that assume pre-defined or literature-based inputs. After determining the required level of model complexity and after conducting power analyses with the pilot data from this R21, we will pursue R01 level funding extending our computational and experimental protocols to further investigate the biomechanics of FAI.

描述（由申请人提供）：股髋臼撞击（FAI）是髋关节间隙的减少，导致髋部疼痛，并可能使髋关节易患骨关节炎（OA）。生物力学的改变被认为是 OA 的关键引发因素。 FAI 患者经常出现软骨盂唇损伤和运动范围受限，这表明 FAI 改变了软骨/盂唇接触力学和髋关节运动学。最近的研究表明，FAI 还可能导致肌肉激活和力量的原发性或适应性变化。 由于过于简化的方法或不准确的测试设备，之前的临床和基础生物力学研究未能阐明 FAI、生物力学改变和 OA 之间的联系。我们的长期目标是通过量化髋关节生物力学来改善 FAI 的诊断和治疗。为了支持这一目标，我们提出了一项 R21 级别的研究，以证明使用组合实验和计算协议来量化人类髋部的关节运动学、肌肉力/激活以及软骨/盂唇接触力学的可行性。 我们将结合使用双透视和基于摄像头的标记跟踪来量化日常生活活动期间的下肢运动学。肌肉骨骼 (MS) 模型将估计肌肉力量/活动，有限元 (FE) 模型将预测软骨盂力学。过去，我们的 MS 模型假设静态髋关节中心和预定义的肌肉附件，而我们的 FE 模型则假设文献中的边界和负载条件。在此 R21 中，我们将比较特定于主题的模型与假设预定义或基于文献的输入的模型之间的 MS 模型（目标 1）和 FE 模型（目标 2）预测。 在确定所需的模型复杂性水平并使用 R21 的试点数据进行功率分析后，我们将寻求 R01 级资金，扩展我们的计算和实验协议，以进一步研究 FAI 的生物力学。