Building sequencing capacity to address nosocomial infections in primary care and referral veterinary medical facilities

建立测序能力以解决初级保健和转诊兽医医疗设施中的院内感染问题

• 批准号: 10215997
• 负责人: Dubraska V Diaz-Campos
• 金额: $ 16.16万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-20 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215997
• 关键词: Building; sequencing; capacity; address; nosocomial

PAR-18-604 Vet-LIRN Network Capacity-building Proposal Project Summary/Abstract The impact of antimicrobial resistance (AMR) in veterinary medicine, as in human healthcare, is widespread and can often include negative patient outcomes and increased treatment costs. Resistant bacteria can contaminate hospital environments and can pose a public health risk of zoonotic transmission. Antimicrobial stewardship programs (ASP) have become the foundation for responding to the antimicrobial resistance crisis in human healthcare, but ASPs in veterinary practice remain significantly undeveloped. At the Ohio State University College of Veterinary Medicine (OSU-CVM), we began developing a Veterinary ASP for our OSU Veterinary Medical Center (OSU-VMC) in 2015. The OSU-CVM BuckeyeASP now provides a framework based on our successful existing program that can be adapted to private veterinary practice. In fall 2020, the BuckeyeASP, a three-year certification program will be offered without cost by the OSU-CVM Antimicrobial Stewardship Working Group (ASWG) to private veterinary practices in Ohio. The program will be promoted by the OSU-CVM and the Ohio Veterinary Medical Association (OVMA). Two primary components of the BuckeyeASP, are the active surveillance of hospital environments and the passive surveillance of clinical isolates recovered from veterinary patients. The three main aims of this proposal are 1) understand the molecular epidemiology of nosocomial infections in primary care and referral veterinary medical facilities in Ohio; 2) establish the impact of veterinary antimicrobial stewardship and infection control program implementation on the patient risk of nosocomial infection in primary care veterinary practices, and 3) create and disseminate antimicrobial stewardship and infection control recommendations for primary care veterinary practices in Ohio. We propose to purchase automated equipment to improve our pathogen sequencing capacity and compile data on nosocomial AMR infections in veterinary medicine. In addition, the Clinical Diagnostic Laboratory of the VMC at Ohio State will adopt emerging technologies currently used to investigate nosocomial infections as well as foodborne illness outbreaks. The adoption of these new technologies will allow the laboratory to train personnel, participate in proficiency tests offered by the Vet-LIRN, and most importantly, to support the network in case investigations when needed.

PAR-18-604 Vet-LIRN网络能力建设提案 项目总结/摘要 抗生素耐药性（AMR）在兽医学中的影响与在人类医疗保健中的影响一样， 广泛存在，并且通常可能包括负面的患者结果和增加的治疗成本。耐 细菌可污染医院环境，并可造成人畜共患病的公共卫生风险。 传输抗菌药物管理计划（ASP）已成为应对 人类医疗保健中的抗生素耐药性危机，但兽医实践中的ASP仍然显着 未开发在俄亥俄州州立大学兽医学院，我们开始了 在2015年为我们的OSU兽医医疗中心（OSU-VMC）开发兽医ASP。OSU-CVM BuckeyeASP现在提供了一个基于我们成功的现有程序的框架， 私人兽医诊所2020年秋季，将提供为期三年的BuckeyeASP认证计划 OSU-CVM抗菌剂管理工作组（ASWG）免费向私人兽医提供 在俄亥俄州执业。该计划将由OSU-CVM和俄亥俄州兽医局推广 协会（OVMA）。BuckeyeASP的两个主要组成部分是医院的主动监测 环境和从兽医患者中回收的临床分离株的被动监测。的 该提案的三个主要目的是：1）了解医院感染的分子流行病学 在初级保健和转诊兽医医疗设施在俄亥俄州; 2）建立兽医的影响， 抗菌药物管理和感染控制计划的实施对患者的风险 初级保健兽医实践中的医院感染，以及3）创建和传播抗菌药物 俄亥俄州初级保健兽医管理和感染控制建议。我们 建议购买自动化设备，以提高我们的病原体测序能力， 兽医中医院内AMR感染的数据。此外，临床诊断实验室 俄亥俄州的VMC将采用目前用于调查医院感染的新兴技术 感染以及食源性疾病爆发。采用这些新技术将使 实验室培训人员，参加Vet-LIRN提供的熟练程度测试，以及大多数 重要的是，在需要时支持网络进行案件调查。