Building sequencing capacity to address nosocomial infections in primary care and referral veterinary medical facilities

PAR-18-604 VET-LIRN网络能力建设提案 项目摘要/摘要 抗菌素耐药性(AMR)对兽医的影响，就像对人类医疗保健一样，是 这一现象普遍存在，往往包括负面的患者结局和增加的治疗费用。耐药 细菌可污染医院环境，并可构成人畜共患病的公共健康风险 变速箱。抗菌管理计划(ASP)已成为应对 人类医疗保健中的抗菌素耐药性危机，但在兽医实践中的ASP仍然显著 未开发的。在俄亥俄州立大学兽医学院(OSU-CVM)，我们开始 2015年为我们的俄亥俄州立大学兽医中心(OSU-VMC)开发了一个兽医ASP。OSU-CVM BuckeyeASP现在提供了一个基于我们成功的现有程序的框架，可以根据需要进行调整 私人兽医诊所。2020年秋季，将提供为期三年的认证计划BuckeyeASP 由OSU-CVM抗菌管理工作组(ASWG)免费提供给私人兽医 在俄亥俄州开业。该计划将由俄亥俄州立大学CVM和俄亥俄州兽医中心推动 协会(OVMA)。BuckeyeASP的两个主要组成部分是对医院的主动监控 环境和从兽医病人身上回收的临床分离株的被动监测。这个 这项建议的三个主要目的是：1)了解医院感染的分子流行病学 在俄亥俄州的初级保健和转诊兽医医疗设施中；2)建立兽医的影响 抗菌药物管理和感染控制程序实施对患者风险的影响 初级保健兽医实践中的医院感染，以及3)创建和传播抗菌剂 俄亥俄州初级保健兽医实践的管理和感染控制建议。我们 建议购买自动化设备以提高我们的病原体测序能力并编制 兽医院内AMR感染资料。此外，临床诊断实验室 俄亥俄州立大学的VMC将采用目前用于调查医院内的新兴技术 感染以及食源性疾病暴发。这些新技术的采用将使 实验室培训人员，参加VET-LIRN提供的能力测试，以及MOST 重要的是，在需要时支持网络进行案件调查。

PAR-18-604 Vet-LIRN Network Capacity-building Proposal Project Summary/Abstract The impact of antimicrobial resistance (AMR) in veterinary medicine, as in human healthcare, is widespread and can often include negative patient outcomes and increased treatment costs. Resistant bacteria can contaminate hospital environments and can pose a public health risk of zoonotic transmission. Antimicrobial stewardship programs (ASP) have become the foundation for responding to the antimicrobial resistance crisis in human healthcare, but ASPs in veterinary practice remain significantly undeveloped. At the Ohio State University College of Veterinary Medicine (OSU-CVM), we began developing a Veterinary ASP for our OSU Veterinary Medical Center (OSU-VMC) in 2015. The OSU-CVM BuckeyeASP now provides a framework based on our successful existing program that can be adapted to private veterinary practice. In fall 2020, the BuckeyeASP, a three-year certification program will be offered without cost by the OSU-CVM Antimicrobial Stewardship Working Group (ASWG) to private veterinary practices in Ohio. The program will be promoted by the OSU-CVM and the Ohio Veterinary Medical Association (OVMA). Two primary components of the BuckeyeASP, are the active surveillance of hospital environments and the passive surveillance of clinical isolates recovered from veterinary patients. The three main aims of this proposal are 1) understand the molecular epidemiology of nosocomial infections in primary care and referral veterinary medical facilities in Ohio; 2) establish the impact of veterinary antimicrobial stewardship and infection control program implementation on the patient risk of nosocomial infection in primary care veterinary practices, and 3) create and disseminate antimicrobial stewardship and infection control recommendations for primary care veterinary practices in Ohio. We propose to purchase automated equipment to improve our pathogen sequencing capacity and compile data on nosocomial AMR infections in veterinary medicine. In addition, the Clinical Diagnostic Laboratory of the VMC at Ohio State will adopt emerging technologies currently used to investigate nosocomial infections as well as foodborne illness outbreaks. The adoption of these new technologies will allow the laboratory to train personnel, participate in proficiency tests offered by the Vet-LIRN, and most importantly, to support the network in case investigations when needed.