Brain Rehabilitation Research Center
脑康复研究中心
基本信息
- 批准号:10268968
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-10-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:AchievementAffectAgeAnimal ModelAttentionAwardBenchmarkingBiological MarkersBrainBrain imagingBudgetsCaringChronicClinicalCognitionCognitiveDiagnosisDiseaseEmotionalEmotionsEquipmentEthnic OriginEtiologyFeedbackFloridaFrightFundingGaitGenderGoalsHealthHealth systemHealthcareHealthcare SystemsHospitalsHumanImpaired cognitionInflammatoryInstitutionInterdisciplinary StudyInterventionLeadershipLocomotor trainingLong-Term CareMeasurementMeasuresMemoryMemory impairmentMentorsMissionMotorNervous System TraumaNeurodegenerative DisordersNeurologicNeuronal PlasticityNeurosciencesOrganizational ModelsPathologicPathologyPerformancePersonal SatisfactionPost-Traumatic Stress DisordersProcessProtocols documentationPsychotherapyQuality of lifeRaceRecoveryRegimenRehabilitation therapyResearchResearch PersonnelResource SharingResourcesRodent ModelRoleScienceServicesStrategic PlanningStrokeStructureSurvivorsTestingTimeTrainingTraumatic Brain InjuryUniversitiesUpper ExtremityUpper limb movementVeteransWalkingcareercentral nervous system injurychronic strokeclinical practiceclinically translatablecognitive recoverycohesioncomorbiditycomparative effectiveness trialcostcost effectivecost estimatedisabilityefficacy evaluationemotion regulationexecutive functionfallsfeasibility testingfunctional restorationgait rehabilitationgenetic varianthuman modelimprovedinnovationmotor recoverymultiple disabilitynervous system disorderneural networkneurological rehabilitationneurophysiologynovelpersistent symptompost strokepre-clinicalprogram disseminationprogramsrehabilitation researchrelating to nervous systemresponseself testingsensory feedbackstroke interventionstroke survivorstroke therapy
项目摘要
The Mission of the Brain Rehabilitation Research Center (BRRC) is:
Maximize recovery of cognitive, emotion, and motor function in Veterans affected by neurologic injury or
disease by potentiating neural plasticity and neural network reorganization through the discovery of
mechanisms and innovation of treatments.
The BRRC is a 19-yr consortium with three major institutions: North Florida/South Georgia VA Health Care
System, University of Florida (UF)/Shands Healthcare, and Brooks Rehabilitation Hospital. The BRRC
supports > 28 investigators (14 PIs with VA-funded studies, 14 associate investigators, and additional
collaborating investigators) and their teams. The BRRC supports a collaborative, interdisciplinary research
team, providing extensive facilities and resources for sophisticated human performance and brain function
measurement. Our planned research programs utilize specific neuroplastic mechanisms to recover cognitive,
emotion, and motor function. First, in the Cognition Function Initiative, we are developing innovative treatment
for impaired memory, executive function, and goal achievement in TBI survivors. Second, in the Emotion
Function Initiative, we are establishing new brain neuromarkers for objective diagnosis of PTSD and prediction
of psychotherapy response in the presence and absence of TBI. We are investigating the etiological,
pathological and neurophysiological mechanisms of PTSD comorbid with TBI, identifying brain networks
involved in the emotional consequences of PTSD/TBI, and testing novel interventions to aid in recovery of
emotion regulation. Third, in the Motor Function Initiative, we are investigating brain activation mechanisms
during walking and during upper limb movement, to elucidate pathology and identify more useful treatment
targets for inducing motor recovery. We are developing and feasibility-testing a new brain neural feedback
regimen (real time brain imaging) to improve upper limb function after stroke. We are testing several
innovative gait training interventions for stroke survivors: combination of gait coordination and brain stimulation;
backward walking training paradigm; enhancing sensory feedback during walking and testing emotional fear
factors related to fall self-efficacy; and feasibility-testing a protocol for a comparative effectiveness trial, for
long-term mobility and health for chronic stroke. Fourth, in the Rehabilitation Neuroscience Initiative (animal
and human models), we are refining our preclinical rodent models of TBI and SCI that reflect clinical symptoms
of chronic and persistent disabilities in human TBI/SCI. We are establishing reliable, quantitative, and clinically
translatable measures for assessing chronic multiple disabilities and for illuminating the role of TBI in chronic
human neurodegenerative disease. We are evaluating efficacy of combined interventions, such as locomotor
training and CNS stimulation, to mitigate TBI-induced disabilities. In stroke and TBI separately, we are
evaluating the impact of potential modifiers such as age, gender, race/ethnicity, and moderating biomarkers of
gene variants, brain structure/function, and inflammatory processes on cognitive impairment.
The BRRC has consistently achieved the benchmarks expected by the RR&D Service, as follows:
* Thematically cohesive, neural plasticity research portfolio focused on RR&D high priority Veteran needs for
those with neurological injury or disease.
* Robust science dissemination program, including national leadership by BRRC investigators.
* Active and successful capacity-building program, including support and mentoring across career stages.
* Excellent funding leverage ratio of Core Center award.
* Acquisition and stewardship of extensive facilities, equipment, and shared resources for investigators.
* Successful organizational model with a track record of strongly supporting investigators, inclusive budget
planning process, visionary strategic planning process.
脑康复研究中心(BRRC)的使命是:
项目成果
期刊论文数量(0)
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{{ truncateString('RUSSELL M BAUER', 18)}}的其他基金
Developing Process-Specific Verbal Memory Interventions for Veterans with TBI
为患有 TBI 的退伍军人制定特定过程的言语记忆干预措施
- 批准号:
8986675 - 财政年份:2015
- 资助金额:
-- - 项目类别:
PSYCHOPHYSIOLOGY OF IMPLICIT MEMORY IN ALCOHOLIC AMNESIA
酒精性遗忘症中内隐记忆的心理生理学
- 批准号:
3109393 - 财政年份:1983
- 资助金额:
-- - 项目类别:
PSYCHOPHYSIOLOGY OF IMPLICIT MEMORY IN ALCOHOLIC AMNESIA
酒精性遗忘症中内隐记忆的心理生理学
- 批准号:
2043401 - 财政年份:1983
- 资助金额:
-- - 项目类别:
PSYCHOPHYSIOLOGY OF IMPLICIT MEMORY IN ALCOHOLIC AMNESIA
酒精性遗忘症中内隐记忆的心理生理学
- 批准号:
2043400 - 财政年份:1983
- 资助金额:
-- - 项目类别:
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