Brain Rehabilitation Research Center

脑康复研究中心(BRRC)的使命是： 最大限度地恢复受神经损伤或退伍军人影响的认知、情绪和运动功能 疾病通过增强神经可塑性和神经网络重组通过发现 治疗机制和创新。 BRRC是一个有19年历史的财团，有三个主要机构：北佛罗里达州/南佐治亚州VA医疗保健 系统，佛罗里达大学(UF)/斯汉兹医疗保健和布鲁克斯康复医院。BRRC 支持&gt；28名调查员(具有退伍军人事务部资助的研究的14名PI、14名助理调查员和其他 合作调查人员)和他们的团队。BRRC支持协作、跨学科的研究 团队，为复杂的人类表现和大脑功能提供广泛的设施和资源 测量。我们计划的研究项目利用特定的神经再生机制来恢复认知能力， 情绪和运动功能。首先，在认知功能倡议中，我们正在开发创新的治疗方法 对于脑外伤幸存者的记忆受损、执行功能和目标实现。第二，在情感上 我们正在建立新的脑神经标记物，用于创伤后应激障碍的客观诊断和预测 有无创伤性脑损伤时的心理治疗反应。我们正在调查病因， 创伤后应激障碍合并脑损伤的病理和神经生理机制 参与创伤后应激障碍/创伤性脑损伤的情绪后果，并测试有助于康复的新干预措施 情绪调节。第三，在运动功能倡议中，我们正在研究大脑激活机制 在行走和上肢运动时，阐明病理并找出更有效的治疗方法 诱导运动恢复的目标。我们正在开发一种新的脑神经反馈并进行可行性测试 方案(实时脑成像)，以改善中风后的上肢功能。我们正在测试几个 卒中幸存者的创新步态训练干预措施：步态协调和脑刺激相结合； 后向行走训练范式；加强行走过程中的感觉反馈并测试情绪恐惧 与下降自我效能相关的因素；以及可行性-测试比较有效性试验的方案， 慢性中风患者的长期活动能力和健康状况。第四，在康复神经科学倡议(动物 和人类模型)，我们正在完善我们的临床前脑损伤和脊髓损伤的啮齿动物模型，以反映临床症状 人类颅脑损伤/脊髓损伤的慢性和永久性残疾。我们正在建立可靠的、定量的和临床的 评估慢性多发性残疾和阐明脑损伤在慢性多发性残疾中的作用的可翻译措施 人类神经退行性疾病。我们正在评估联合干预的效果，如运动 训练和中枢神经系统刺激，以减轻颅脑损伤所致的残疾。在中风和脑外伤中，我们分别是 评估潜在修饰物的影响，如年龄、性别、种族/民族，以及调节 认知障碍的基因变异、脑结构/功能和炎症过程。 BRRC始终如一地达到了RR&D处预期的基准，具体如下： *主题连贯、神经可塑性研究组合专注于RR&D退伍军人的高优先级需求 有神经损伤或疾病的人。 *强有力的科学传播计划，包括BRRC调查人员的国家领导。 *积极和成功的能力建设方案，包括跨职业阶段的支持和指导。 *核心中心奖优秀的资金杠杆率。 *为调查人员购置和管理广泛的设施、设备和共享资源。 *成功的组织模式，有大力支持调查人员的记录，包括预算 规划过程，富有远见的战略规划过程。

The Mission of the Brain Rehabilitation Research Center (BRRC) is: Maximize recovery of cognitive, emotion, and motor function in Veterans affected by neurologic injury or disease by potentiating neural plasticity and neural network reorganization through the discovery of mechanisms and innovation of treatments. The BRRC is a 19-yr consortium with three major institutions: North Florida/South Georgia VA Health Care System, University of Florida (UF)/Shands Healthcare, and Brooks Rehabilitation Hospital. The BRRC supports > 28 investigators (14 PIs with VA-funded studies, 14 associate investigators, and additional collaborating investigators) and their teams. The BRRC supports a collaborative, interdisciplinary research team, providing extensive facilities and resources for sophisticated human performance and brain function measurement. Our planned research programs utilize specific neuroplastic mechanisms to recover cognitive, emotion, and motor function. First, in the Cognition Function Initiative, we are developing innovative treatment for impaired memory, executive function, and goal achievement in TBI survivors. Second, in the Emotion Function Initiative, we are establishing new brain neuromarkers for objective diagnosis of PTSD and prediction of psychotherapy response in the presence and absence of TBI. We are investigating the etiological, pathological and neurophysiological mechanisms of PTSD comorbid with TBI, identifying brain networks involved in the emotional consequences of PTSD/TBI, and testing novel interventions to aid in recovery of emotion regulation. Third, in the Motor Function Initiative, we are investigating brain activation mechanisms during walking and during upper limb movement, to elucidate pathology and identify more useful treatment targets for inducing motor recovery. We are developing and feasibility-testing a new brain neural feedback regimen (real time brain imaging) to improve upper limb function after stroke. We are testing several innovative gait training interventions for stroke survivors: combination of gait coordination and brain stimulation; backward walking training paradigm; enhancing sensory feedback during walking and testing emotional fear factors related to fall self-efficacy; and feasibility-testing a protocol for a comparative effectiveness trial, for long-term mobility and health for chronic stroke. Fourth, in the Rehabilitation Neuroscience Initiative (animal and human models), we are refining our preclinical rodent models of TBI and SCI that reflect clinical symptoms of chronic and persistent disabilities in human TBI/SCI. We are establishing reliable, quantitative, and clinically translatable measures for assessing chronic multiple disabilities and for illuminating the role of TBI in chronic human neurodegenerative disease. We are evaluating efficacy of combined interventions, such as locomotor training and CNS stimulation, to mitigate TBI-induced disabilities. In stroke and TBI separately, we are evaluating the impact of potential modifiers such as age, gender, race/ethnicity, and moderating biomarkers of gene variants, brain structure/function, and inflammatory processes on cognitive impairment. The BRRC has consistently achieved the benchmarks expected by the RR&D Service, as follows: * Thematically cohesive, neural plasticity research portfolio focused on RR&D high priority Veteran needs for those with neurological injury or disease. * Robust science dissemination program, including national leadership by BRRC investigators. * Active and successful capacity-building program, including support and mentoring across career stages. * Excellent funding leverage ratio of Core Center award. * Acquisition and stewardship of extensive facilities, equipment, and shared resources for investigators. * Successful organizational model with a track record of strongly supporting investigators, inclusive budget planning process, visionary strategic planning process.