Brain Rehabilitation Research Center

脑康复研究中心

• 批准号: 9910074
• 负责人: RUSSELL M BAUER
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910074
• 关键词: Achievement; Affect; Age; Animal Model; Attention; Award; Benchmarking; Biological Markers; Brain; Brain imaging; Budgets; Caring; Chronic; Clinical; Cognition; Cognitive; Diagnosis; Disease; Emotional; Emotions; Equipment; Ethnic Origin; Etiology; Feedback; Florida; Fright; Funding; Gait; Gender; Goals; Health; Health system; Healthcare; Healthcare Systems; Hospitals; Human; Impaired cognition; Inflammatory; Institution; Interdisciplinary Study; Intervention; Leadership; Locomotor training; Long-Term Care; Measurement; Measures; Memory; Memory impairment; Mentors; Mission; Motor; Nervous System Trauma; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Neurosciences; Organizational Models; Pathologic; Pathology; Performance; Personal Satisfaction; Post-Traumatic Stress Disorders; Process; Protocols documentation; Psychotherapy; Quality of life; Race; Recovery; Regimen; Rehabilitation therapy; Research; Research Personnel; Resource Sharing; Resources; Rodent Model; Role; Science; Self Efficacy; Services; Strategic Planning; Stroke; Structure; Survivors; Testing; Time; Training; Traumatic Brain Injury; Universities; Upper Extremity; Upper limb movement; Veterans; Walking; career; central nervous system injury; chronic stroke; clinical practice; clinically translatable; cognitive recovery; cohesion; comorbidity; comparative effectiveness trial; cost; cost effective; cost estimate; disability; emotion regulation; executive function; falls; functional restoration; gait rehabilitation; genetic variant; human model; improved; innovation; motor recovery; multiple disability; nervous system disorder; neural network; neurological rehabilitation; neurophysiology; novel; persistent symptom; post stroke; pre-clinical; program dissemination; programs; rehabilitation research; relating to nervous system; response; sensory feedback; stroke intervention; stroke survivor; stroke therapy

The Mission of the Brain Rehabilitation Research Center (BRRC) is: Maximize recovery of cognitive, emotion, and motor function in Veterans affected by neurologic injury or disease by potentiating neural plasticity and neural network reorganization through the discovery of mechanisms and innovation of treatments. The BRRC is a 19-yr consortium with three major institutions: North Florida/South Georgia VA Health Care System, University of Florida (UF)/Shands Healthcare, and Brooks Rehabilitation Hospital. The BRRC supports > 28 investigators (14 PIs with VA-funded studies, 14 associate investigators, and additional collaborating investigators) and their teams. The BRRC supports a collaborative, interdisciplinary research team, providing extensive facilities and resources for sophisticated human performance and brain function measurement. Our planned research programs utilize specific neuroplastic mechanisms to recover cognitive, emotion, and motor function. First, in the Cognition Function Initiative, we are developing innovative treatment for impaired memory, executive function, and goal achievement in TBI survivors. Second, in the Emotion Function Initiative, we are establishing new brain neuromarkers for objective diagnosis of PTSD and prediction of psychotherapy response in the presence and absence of TBI. We are investigating the etiological, pathological and neurophysiological mechanisms of PTSD comorbid with TBI, identifying brain networks involved in the emotional consequences of PTSD/TBI, and testing novel interventions to aid in recovery of emotion regulation. Third, in the Motor Function Initiative, we are investigating brain activation mechanisms during walking and during upper limb movement, to elucidate pathology and identify more useful treatment targets for inducing motor recovery. We are developing and feasibility-testing a new brain neural feedback regimen (real time brain imaging) to improve upper limb function after stroke. We are testing several innovative gait training interventions for stroke survivors: combination of gait coordination and brain stimulation; backward walking training paradigm; enhancing sensory feedback during walking and testing emotional fear factors related to fall self-efficacy; and feasibility-testing a protocol for a comparative effectiveness trial, for long-term mobility and health for chronic stroke. Fourth, in the Rehabilitation Neuroscience Initiative (animal and human models), we are refining our preclinical rodent models of TBI and SCI that reflect clinical symptoms of chronic and persistent disabilities in human TBI/SCI. We are establishing reliable, quantitative, and clinically translatable measures for assessing chronic multiple disabilities and for illuminating the role of TBI in chronic human neurodegenerative disease. We are evaluating efficacy of combined interventions, such as locomotor training and CNS stimulation, to mitigate TBI-induced disabilities. In stroke and TBI separately, we are evaluating the impact of potential modifiers such as age, gender, race/ethnicity, and moderating biomarkers of gene variants, brain structure/function, and inflammatory processes on cognitive impairment. The BRRC has consistently achieved the benchmarks expected by the RR&D Service, as follows: * Thematically cohesive, neural plasticity research portfolio focused on RR&D high priority Veteran needs for those with neurological injury or disease. * Robust science dissemination program, including national leadership by BRRC investigators. * Active and successful capacity-building program, including support and mentoring across career stages. * Excellent funding leverage ratio of Core Center award. * Acquisition and stewardship of extensive facilities, equipment, and shared resources for investigators. * Successful organizational model with a track record of strongly supporting investigators, inclusive budget planning process, visionary strategic planning process.

脑康复研究中心（BRRC）的使命是： 最大限度地恢复受神经损伤影响的退伍军人的认知、情感和运动功能， 疾病通过增强神经可塑性和神经网络重组，通过发现 治疗机制和创新。 BRRC是一个有19年历史的财团，有三个主要机构：北佛罗里达/南格鲁吉亚弗吉尼亚州卫生保健 系统，佛罗里达大学（UF）/尚兹医疗保健和布鲁克斯康复医院。BRRC 支持> 28名研究者（14名参与VA资助研究的PI，14名助理研究者，以及其他研究者） 合作研究人员）及其团队。BRRC支持跨学科的合作研究 团队，为复杂的人类表现和大脑功能提供广泛的设施和资源 测量.我们计划的研究项目利用特定的神经可塑性机制来恢复认知， 情绪和运动功能首先，在认知功能倡议中，我们正在开发创新的治疗方法， 创伤性脑损伤幸存者的记忆、执行功能和目标实现受损。第二，在情感中 功能倡议，我们正在建立新的大脑神经标记物，用于PTSD的客观诊断和预测 心理治疗的反应在存在和不存在创伤性脑损伤。我们正在调查病因， 创伤后应激障碍与创伤性脑损伤共病的病理学和神经生理学机制， 参与创伤后应激障碍/创伤性脑损伤的情绪后果，并测试新的干预措施，以帮助恢复 emotion regulation.第三，在运动功能倡议中，我们正在研究大脑激活机制， 在行走和上肢运动期间，阐明病理学并确定更有用的治疗方法 诱导运动恢复的目标。我们正在开发和可行性测试一种新的大脑神经反馈 方案（真实的时间脑成像），以改善中风后上肢功能。我们正在测试几个 中风幸存者的创新步态训练干预：步态协调和脑刺激相结合; 倒走训练范式;增强步行过程中的感觉反馈和测试情绪恐惧 与跌倒自我效能相关的因素;以及可行性测试一项比较有效性试验的方案， 长期的流动性和健康的慢性中风。第四，在康复神经科学倡议（动物 和人类模型），我们正在完善反映临床症状的TBI和SCI临床前啮齿动物模型 TBI/SCI患者的慢性和持续性残疾。我们正在建立可靠的，定量的，临床的 评估慢性多重残疾和阐明TBI在慢性 人类神经退行性疾病。我们正在评估联合干预的有效性，例如运动 训练和中枢神经系统刺激，以减轻TBI引起的残疾。在中风和TBI分别，我们是 评估潜在修饰因素（如年龄、性别、种族/民族）和调节生物标志物的影响， 基因变异、大脑结构/功能和炎症过程对认知障碍的影响。 该中心一直达到驻地协调员和发展处预期的基准，具体如下： * 主题连贯，神经可塑性研究组合专注于RR&D高优先级退伍军人的需求， 有神经损伤或疾病的人。 * 强大的科学传播计划，包括BRRC调查人员的国家领导。 * 积极和成功的能力建设计划，包括跨职业阶段的支持和指导。 * 卓越的核心中心奖资金杠杆率。 * 为调查人员购置和管理大量设施、设备和共享资源。 * 成功的组织模式，有强烈支持研究者的记录，包容性预算 规划过程，有远见的战略规划过程。