THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

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Project Summary NIA has established the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) as a national genetics data repository in order to facilitate access by qualified investigators to genotypic data for the study of the genetics of late-onset Alzheimer's Disease (AD). It is the policy of the NIA that all Genetic Data derived from NIA funded studies for the genetics of late-onset Alzheimer's disease be deposited at NIAGADS or another NIA approved site or both whenever possible. NIAGADS is also the Data Coordinating Center for Alzheimer's Disease Sequencing Project (ADSP), a National Institute on Aging initiative to identify new genetic variants by sequencing genomes/exomes of more than 30,000 AD patients and cognitively normal controls. In the third funding period, NIAGADS will continue our primary mission as the national repository for AD genetics and genomics, support ADSP data coordination, and collaborate with NIA- funded and other relevant ADRD research initiatives. The growing data will evolve into a long-lasting resource and a major legacy of ADSP. NIAGADS will: (1) Curate, update, and disseminate a high-quality, lasting data collection with 80,000 or more genomes for ADRD genetics/genomics research; (2) Support ADSP data production and analysis activities; (3) Develop informatics infrastructure for cloud-based data analysis, management and dissemination; (4) Expand computational tools for genetic and genomic data annotation, report and visualization; (5) Collaborate with other research resources and initiatives, and expand the outreach program.