THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

摘要/概要 NIA阿尔茨海默病遗传学数据存储网站（NIAGADS）是一站式访问门户网站， 阿尔茨海默病遗传学，并作为阿尔茨海默病的数据协调中心 测序项目（ADSP）。自NIAGADS提交延期以来，ADSP已大幅扩展 2016年的应用，包括处理来自119个队列的多达114，335个基因组的序列数据（10 是最初预期的两倍）和三项关于机器学习分析的新重大举措， 表型协调和功能基因组学。NIA和NIAGADS都没有预料到 主要增长或新的NIA倡议时，原始应用程序编写，它是 我们必须增强NIAGADS的能力，以保持有效的运作， 补充申请。 拟议的行政补充旨在增强NIAGADS的能力， 为国家执行机构实现其国家适应行动方案的目标，该请求 在原研究计划的范围内，包括四项任务：（1）增加程序员 支持维护NIAGADS云数据共享服务及其安全性;（2）开发云计算工具， 基于云的数据分析;（3）与凯斯西储大学合作，以增强我们基于云的 （4）扩大NIAGADS的覆盖面，建立一个网站， 向更广泛的受众传播AD遗传学研究。

Abstract/Summary NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is a one-stop access portal for Alzheimer's disease genetics and serves as the data coordinating center for the Alzheimer's Disease Sequencing Project (ADSP). ADSP has expanded substantially since NIAGADS submitted the renewal application in 2016, including processing sequence data of up to 114,335 genomes from 119 cohorts (10 times what was anticipated initially) and three new major initiatives on machine learning analysis, phenotype harmonization, and functional genomics. Neither NIA nor NIAGADS could have anticipated the major growth or the new NIA initiatives when the original application was written, and it is imperative that we augment the capacity of NIAGADS to maintain efficient operations with this supplement request. The proposed administrative supplement aims to augment the capacity of NIAGADS and maintain efficient operations for ADSP support in order that NIA meets its NAPA Milestones. The request is within the scope of the original research plan and includes four tasks: (1) additional programmer support to maintain NIAGADS cloud data sharing service and its security; (2) develop tools for cloud- based data analysis; (3) collaborate with Case Western Reserve University to enhance our cloud-based computing infrastructure for ADSP data analysis; (4) expand NIAGADS outreach with a website for disseminating AD genetics research to a wider audience.