CORE B-Data Management, Harmonization, and Information Transfer Core

CORE B-数据管理、协调和信息传输核心

• 批准号: 10090894
• 负责人: LI-SAN WANG
• 金额: $ 265.46万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090894
• 关键词: Alzheimer' s Disease; Alzheimer' s Disease Core Center; Alzheimer' s disease related dementia; Automobile Driving; Biostatistics Core; ChIP-seq; Communities; Computer software; Data; Data Analyses; Data Files; Data Set; Data Storage and Retrieval; Deposition; Documentation; Ensure; Environment; Genes; Genetic; Genetic Research; Genome; Genotype; Haplotypes; Image; Information Dissemination; Information Technology; Joints; Output; Pathway Analysis; Phase; Phenotype; Process; Production; Protocols documentation; Quality Control; Research; Research Personnel; Site; Source; Source Code; Structure; Testing; Variant; Work; cloud based; cloud platform; computer code; computer infrastructure; computerized data processing; data harmonization; data management; data quality; data sharing; design; distributed data; exome; exome sequencing; follow-up; functional genomics; gene interaction; genetic variant; genome wide association study; genomic data; in silico; insertion/deletion mutation; phenotypic data; programs; repository; transcriptome sequencing; web site; whole genome

Core B Project Summary Core B (Data Management, Harmonization, and Information Transfer Core) is responsible for facilitating analysis of Alzheimer’s Disease Sequence Project (ADSP) data and other relevant projects by processing and harmonizing all relevant genetic and functional genomics (FG) data. Core B will manage all phenotype, genotype, annotation, and analysis results, and distribute data/files to all ADSP investigators and to NIA Genetics of Alzheimer’s Data Storage Site (NIAGADS), the NIA-designated qualified access repository for AD genetics research. Specific Aims are: (1) Receive and manage all relevant genotypic, phenotypic, and functional genomic data; (2) Calling SNVs, indels and structural variants (SVs) from sequencing data; (3) Develop a GCAD haplotype reference panel with GCAD WGS data for GWAS imputation; (4) Facilitate harmonization of FG/omics data by developing best practices for data processing and coordinate harmonization of ADSP FG Program and other relevant omics data; (5) Support GCAD information technology needs and information dissemination activities.

核心B项目摘要 核心B（数据管理、协调和信息传输核心）负责 促进阿尔茨海默病序列项目（ADSP）数据和其他相关数据的分析， 通过处理和协调所有相关的遗传和功能基因组学（FG）数据， 核心B将管理所有表型、基因型、注释和分析结果，并分发 所有ADSP研究者和NIA阿尔茨海默病遗传学数据存储网站的数据/文件 （NIAGADS），NIA指定的AD遗传学研究合格访问库。具体 目的是：（1）接收和管理所有相关的基因型，表型和功能基因组 数据;（2）从测序数据中调用SNV、插入缺失和结构变体（SV）;（3）开发一个 具有GCAD WGS数据的GCAD单倍型参考组用于GWAS插补; 通过制定数据处理的最佳实践来协调FG/组学数据， 协调ADSP FG计划和其他相关组学数据的协调;（5）支持 GCAD信息技术需求和信息传播活动。