THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

阿尔茨海默病数据存储站点的 NIA 遗传学

• 批准号: 9899175
• 负责人: LI-SAN WANG
• 金额: $ 173.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899175
• 关键词: Abbreviations; Address; Affect; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; American; Archives; Cognitive; Collection; Communities; Community Outreach; Computer software; DNA Sequence; Data; Data Collection; Data Coordinating Center; Data Provenance; Data Set; Data Storage and Retrieval; Databases; Dementia; Dependence; Deposition; Disease; Documentation; Drug Targeting; Educational workshop; Ensure; Fostering; Funding; Gene Expression; Genes; Genetic; Genetic Diseases; Genetic Research; Genetic study; Genomics; Genotype; Human Genetics; Infrastructure; Knowledge; Late Onset Alzheimer Disease; Link; Maps; Medical; Mission; National Human Genome Research Institute; National Institute on Aging; Neurosciences; Newsletter; Ontology; Pathway interactions; Phenotype; Policies; Process; Production; Publications; Research; Research Personnel; Resources; Retrieval; SNP array; Sampling; Sequence Alignment; Single Nucleotide Polymorphism; Site; U-Series Cooperative Agreements; United States National Institutes of Health; Variant; Visualization; cell repository; community involvement; data collection site; data infrastructure; data resource; data sharing; data warehouse; database of Genotypes and Phenotypes; design; exome; gene interaction; genetic variant; genome sequencing; genome wide association study; genome-wide; genomic data; improved; insight; meetings; novel; outreach program; phenotypic data; posters; prevent; programs; repository; symposium; tool; web interface; web site; whole genome

Project Summary NIA has established the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) as a national genetics data repository in order to facilitate access by qualified investigators to genotypic data for the study of the genetics of late-onset Alzheimer's Disease (AD). It is the policy of the NIA that all Genetic Data derived from NIA funded studies for the genetics of late-onset Alzheimer's disease be deposited at NIAGADS or another NIA approved site or both whenever possible. NIAGADS is also the Data Coordinating Center for Alzheimer's Disease Sequencing Project (ADSP), a White House/NIH initiative to identify new genetic variants by sequencing genomes/exomes of ~15,000 AD patients and cognitively normal controls. In the second funding period, NIAGADS will continue its mission as the national repository for AD genetics with these proposed activities: (1) receive and organize AD genetics datasets for community access, (2) coordinate data production and support analysis activities for ADSP, (3) develop the AD Genomics Information Gateway (AD-GIG), an integrated information platform for researchers to access AD knowledge, data, and other resources at NIAGADS more easily, (4) expand NIAGADS resource by interfacing with other research initiatives, and (5) promote community involvement with an active outreach program.

项目摘要 NIA建立了国家老年痴呆症遗传学研究所数据存储网站 （NIAGADS）作为国家遗传学数据库，以方便合格的研究人员获得 晚发性阿尔茨海默病（AD）遗传学研究的基因型数据。这是NIA的政策 所有来自NIA资助的晚发性阿尔茨海默病遗传学研究的遗传数据， 存放在NIAGADS或另一个NIA批准的地点或尽可能存放在两者。NIAGADS也是数据 阿尔茨海默病测序项目协调中心（ADSP）是白宫/NIH的一项倡议， 通过对约15，000名认知正常的AD患者的基因组/外显子组进行测序， 对照在第二个供资期，NIAGADS将继续其作为AD国家资料库的使命 遗传学与这些拟议的活动：（1）接收和组织AD遗传学数据集供社区访问， (2)协调ADSP的数据生成并支持分析活动，（3）开发AD基因组学 信息门户（AD-GIG）是研究人员获取AD知识的综合信息平台， 数据和其他资源在NIAGADS更容易，（4）扩大NIAGADS资源，通过与其他接口 研究倡议，和（5）促进社区参与积极的外展计划。