Core A: Administrative and Scientific Development Core

项目摘要/摘要 微生物致病和宿主炎症反应中心在第一阶段的第一个目标 是把一群有前途的年轻调查人员聚集在一起，他们的研究重点是建筑群 不同微生物病原体及其共同人类宿主之间的相互作用，并提供这些 拥有建立富有成效的独立研究事业所需的支持结构的调查人员。这个 第二个目标是在这些调查人员成功的基础上，将该计划扩大到包括其他 调查人员的工作与这一基本主题相一致，从而达到所需的临界质量 建立自给自足的生物医学研究卓越中心。该中心的首要目标是 促进这些研究人员在治疗上解决传染病问题的能力 通过了解促成疾病过程的微生物毒力因素来实现相关方式 以及这些因素如何影响宿主的免疫和炎症反应，从而提供 操纵这些因素以有利于东道主所需的关键基础。正如在总体上描述的 作为第二阶段续签申请的组成部分，我们在实现这些目标方面取得了巨大进展， 现在处于有利地位，可以从发展阶段(第一阶段)过渡到成长阶段(第二阶段)。一把钥匙 这一过渡的组成部分是我们的行政和科学发展核心(核心A)。具体地说，核心 A将继续为中心提供行政、财政和科学支持(目标1)，促进科学 通过指导和师资发展促进研究人员的成长(目标2)，并促进成长和 通过招聘新的调查人员和促进合作和 中心内部和更广泛的东道校园内的协同互动(目标3)。至 这些目标，核心A将依靠经验丰富的管理团队，内部和外部的建议 咨询委员会，并为每个中心调查员提供经验丰富的导师。核心集团的领导团队已经 促进了第一阶段项目负责人的成功，并建立了强大的新调查人员渠道，以及 在第二阶段期间，将采取措施确保这些新项目负责人的成功，促进继续 成功获得R01资金的一期项目负责人，维护新中心的管道 研究人员，并促进中心之间合作和协同研究关系的发展 研究人员本身和东道主校园内的其他科学家(阿肯色大学医学院 科学和阿肯色州儿童医院研究所)拥有共同的研究兴趣。成功将会 根据在第二阶段实现以下里程碑的能力来判断：1)获得不少于五个新的R01- 级别资助，2)至少两个第一阶段项目负责人续签资助，3)以高质量发表25-50篇稿件- 影响期刊，以及4)提交了P01，其中包括两名或更多中心调查人员。

PROJECT SUMMARY/ABSTRACT The first goal for the Center for Microbial Pathogenesis and Host Inflammatory Responses during Phase I was to bring together a group of promising young investigators whose research focuses on the complex interactions among diverse microbial pathogens and their common human host and to provide these investigators with the support structure required to establish productive, independent research careers. The second goal was to build on the success of these investigators to expand the program to include additional investigators whose work is consistent with this underlying theme, thereby achieving the critical mass required to establish a self-sustaining Center of Biomedical Research Excellence. The overarching goal of the Center is to promote the ability of these investigators to address problems in infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory responses, thereby providing the critical foundation required to manipulate these factors in favor of the host. As described in the Overall component of this Phase II renewal application, we have made tremendous progress toward these goals and are now in strong position to transition from a developmental (Phase I) to a growth stage (Phase II). A key component of this transition is our Administrative and Scientific Development Core (Core A). Specifically, Core A will continue to provide administrative, fiscal, and scientific support for the Center (Aim 1), foster the scientific growth of its investigators through mentoring and faculty development (Aim 2), and foster growth and expansion of the Center through the recruitment of new investigators and facilitating collaborative and synergistic interactions both within the Center and more broadly on the host campuses at large (Aim 3). To these ends, Core A will rely on a seasoned administrative team, the advice of both Internal and External Advisory Committees, and experienced mentors for each Center investigator. The Core's leadership team has fostered the success of Phase I Project Leaders and developed a robust pipeline of new investigators, and during Phase II steps will be taken to ensure the success of these new Project Leaders, promote the continued success of Phase I Project Leaders who obtained R01 funding, maintain the pipeline of new Center investigators, and promote development of collaborative and synergistic research relationships among Center investigators themselves and other scientists on the host campuses (University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute) with common research interests. Success will be judged by the ability to achieve the following milestones in Phase II: 1) obtain no fewer than five new R01- level grants, 2) have at least two Phase I Project Leaders renew grants, 3) publish 25–50 manuscripts in high- impact journals, and 4) have a P01 submitted that includes two or more Center investigators.