Core A: Administrative and Scientific Development Core

项目总结/摘要 微生物发病机制和宿主炎症反应中心在第一阶段的第一个目标 是召集一群有前途的年轻研究人员，他们的研究重点是 不同微生物病原体及其共同人类宿主之间的相互作用，并提供这些 研究人员与所需的支持结构，以建立生产，独立的研究生涯。的 第二个目标是在这些调查人员成功的基础上扩大该计划， 其工作符合这一基本主题的调查员，从而达到所需的足够数量 建立一个自我维持的卓越生物医学研究中心。中心的首要目标是 提高这些研究人员的能力，以解决传染病问题的治疗， 相关的时尚，通过了解微生物的毒力因子，有助于疾病的过程 以及这些因素如何影响宿主的免疫和炎症反应，从而提供 关键的基础需要操纵这些因素有利于主机。如总体报告所述， 作为第二阶段更新申请的组成部分，我们在实现这些目标方面取得了巨大进展， 现在处于从发展阶段（第一阶段）过渡到增长阶段（第二阶段）的有利地位。一个关键 这一转变的组成部分是我们的行政和科学发展核心（核心A）。具体而言，核心 A将继续为中心提供行政、财政和科学支持（目标1）， 通过指导和教师发展（目标2），促进研究人员的成长， 通过招募新的研究人员和促进合作， 中心内部和更广泛的主办校园之间的协同互动（目标3）。到 为了实现这些目标，核心A将依靠一个经验丰富的管理团队，内部和外部的建议， 咨询委员会和每位中心研究者的经验丰富的导师。核心的领导团队 促进了第一阶段项目领导人的成功，并建立了一个强大的新调查人员管道， 在第二阶段，将采取措施确保这些新的项目领导人取得成功，促进 第一阶段项目负责人成功获得R 01资金，维持新中心的管道 研究人员，并促进中心之间的合作和协同研究关系的发展 研究人员本人和主办校园（阿肯色州医学大学）的其他科学家 科学和阿肯色州儿童医院研究所）有共同的研究兴趣。成功将 通过在第二阶段实现以下里程碑的能力来判断：1）获得不少于5个新的R 01- 2）至少有两个第一阶段项目负责人更新赠款，3）发表25-50篇高水平的手稿， 有影响力的期刊，以及4）提交了包括两名或更多中心研究者的P01。

PROJECT SUMMARY/ABSTRACT The first goal for the Center for Microbial Pathogenesis and Host Inflammatory Responses during Phase I was to bring together a group of promising young investigators whose research focuses on the complex interactions among diverse microbial pathogens and their common human host and to provide these investigators with the support structure required to establish productive, independent research careers. The second goal was to build on the success of these investigators to expand the program to include additional investigators whose work is consistent with this underlying theme, thereby achieving the critical mass required to establish a self-sustaining Center of Biomedical Research Excellence. The overarching goal of the Center is to promote the ability of these investigators to address problems in infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory responses, thereby providing the critical foundation required to manipulate these factors in favor of the host. As described in the Overall component of this Phase II renewal application, we have made tremendous progress toward these goals and are now in strong position to transition from a developmental (Phase I) to a growth stage (Phase II). A key component of this transition is our Administrative and Scientific Development Core (Core A). Specifically, Core A will continue to provide administrative, fiscal, and scientific support for the Center (Aim 1), foster the scientific growth of its investigators through mentoring and faculty development (Aim 2), and foster growth and expansion of the Center through the recruitment of new investigators and facilitating collaborative and synergistic interactions both within the Center and more broadly on the host campuses at large (Aim 3). To these ends, Core A will rely on a seasoned administrative team, the advice of both Internal and External Advisory Committees, and experienced mentors for each Center investigator. The Core's leadership team has fostered the success of Phase I Project Leaders and developed a robust pipeline of new investigators, and during Phase II steps will be taken to ensure the success of these new Project Leaders, promote the continued success of Phase I Project Leaders who obtained R01 funding, maintain the pipeline of new Center investigators, and promote development of collaborative and synergistic research relationships among Center investigators themselves and other scientists on the host campuses (University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute) with common research interests. Success will be judged by the ability to achieve the following milestones in Phase II: 1) obtain no fewer than five new R01- level grants, 2) have at least two Phase I Project Leaders renew grants, 3) publish 25–50 manuscripts in high- impact journals, and 4) have a P01 submitted that includes two or more Center investigators.