Center for Microbial Pathogenesis and Host Inflammatory Responses

项目摘要/摘要 以治疗相关的方式解决传染病需要理解 促进疾病进程的微生物毒力因素以及这些因素影响的方式 宿主的免疫和炎症反应。实现这一点将为小说的发展提供机会 影响病原体和/或寄主反应的策略有利于寄主，从而提供完美的 临床相关转化研究的机会。因此，实现这一理解仍然是 我们微生物致病和宿主炎症反应中心的总体目标。关键要素是 要做到这一点，就是召集一大批调查人员，每个人都在老牌公司的指导下 资深教员，他们的研究与这一潜在的科学主题和我们的总体目标是一致的 中心。将这些研究人员联系在一起的潜在假设是，针对不同的微生物 病原体对普通人免疫和炎症反应的影响 东道主将优化机会，就东道主的反应和其 对疾病进程的不利后果。为此，该应用程序将项目负责人聚集在一起 从两种病原体的角度关注不同微生物病原体的四名研究人员 以及它们对宿主炎症反应的影响。支持这些调查人员，并建立一个 新研究人员的流水线，他们的研究与我们潜在的科学主题一致，我们建议 为所有中心调查人员提供集成且高度互动的教师发展计划 在第一阶段开发的资源使我们的第二阶段项目负责人和其他中心调查人员能够 在符合这一基本主题(目标1)的领域建立独立资助的研究事业； 运用管理科学发展观(核心A)与研究技术进步 (核心B)第一阶段开发的核心，以继续推动中心的科学发展 调查人员和加强东道国校园的整体研究基础设施(目标2)；并在此基础上 我们的第一阶段努力成功地招募了更多的调查人员，他们的研究与 以科学为主题，促进发展协作、协同的研究关系 在中心调查人员中(目标3)。这将使我们能够在第一阶段项目负责人的成功基础上再接再厉 建立一个自给自足的微生物致病和宿主炎症反应中心。

PROJECT SUMMARY/ABSTRACT Addressing infectious disease in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in favor of the host, thereby providing a perfect opportunity for clinically relevant translational research. Thus, achieving this understanding continues to be the overall goal of our Center for Microbial Pathogenesis and Host Inflammatory Responses. The key element to accomplishing this is to assemble a critical mass of investigators, each under the mentorship of established senior faculty, whose research is consistent with this underlying scientific theme and the overall goals of our Center. The underlying hypothesis that ties these investigators together is that targeting diverse microbial pathogens in the context of their impact on immunological and inflammatory responses in their common human host will optimize opportunities for the elucidation of common themes with respect to the host response and its adverse consequences on the disease process. To this end, this application brings together as Project Leaders four investigators who focus on diverse microbial pathogens from the point of view of both the pathogens themselves and their impact on host inflammatory responses. To support these investigators, and to build a pipeline of new investigators whose research is consistent with our underlying scientific theme, we propose to provide an integrated and highly interactive faculty development plan for all Center investigators that leverages the resources developed during Phase I to enable our Phase II Project Leaders and other Center investigators to establish independently-funded research careers in an area consistent with this underlying theme (Aim 1); to utilize the Administrative and Scientific Development (Core A) and Research and Technical Advancement (Core B) cores developed during Phase I to continue to promote the scientific development of Center investigators and enhance the overall research infrastructure on the host campuses (Aim 2); and to build on the success of our Phase I efforts to recruit additional investigators whose research is consistent with the underlying scientific theme and promote the development of collaborative, synergistic research relationships among Center investigators (Aim 3). This will allow us to build on the success of Phase I Project Leaders to establish a self-sustaining Center for Microbial Pathogenesis and Host Inflammatory Responses.