Project-005

以治疗相关的方式应对传染病需要了解 有助于疾病过程的微生物毒力因子以及这些因子影响的方式 宿主的免疫和炎症反应。实现这一目标将为开发新的 策略来影响病原体和/或宿主的反应，从而提供一个完美的 临床相关转化研究的机会。因此，实现这一理解仍然是 我们的微生物发病机制和宿主炎症反应中心的总体目标。的关键因素 要做到这一点，就必须召集足够数量的调查人员，每个人都要接受既定的 高级教师，其研究与这一基本科学主题和我们的总体目标是一致的 中心将这些研究人员联系在一起的基本假设是， 病原体在其影响免疫和炎症反应的背景下，在其共同的人类 东道方将尽可能利用机会阐明关于东道方回应及其 对疾病进程的不利影响。为此，该应用程序汇集了项目领导人 四名研究人员从两种病原体的角度关注不同的微生物病原体 它们本身及其对宿主炎症反应的影响。为了支持这些调查人员，并建立一个 管道的新研究人员的研究是符合我们的基本科学主题，我们建议 为所有中心研究人员提供一个综合的、高度互动的教师发展计划， 第一阶段开发的资源，使我们的第二阶段项目负责人和其他中心研究人员能够 在符合这一基本主题的领域建立独立资助的研究事业（目标1）; 利用行政和科学发展（核心A）以及研究和技术进步 (Core B）一期开发的核心，继续推动中心科学发展 研究员和加强东道校园的整体研究基础设施（目标2）;以及 我们在第一阶段招募更多研究人员的努力取得了成功，这些研究人员的研究符合 基础科学主题，促进发展合作，协同研究关系 中心研究者（目标3）。这将使我们能够在第一阶段项目领导人成功的基础上， 建立一个自我维持的微生物发病机制和宿主炎症反应中心。

Addressing infectious disease in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in favor of the host, thereby providing a perfect opportunity for clinically relevant translational research. Thus, achieving this understanding continues to be the overall goal of our Center for Microbial Pathogenesis and Host Inflammatory Responses. The key element to accomplishing this is to assemble a critical mass of investigators, each under the mentorship of established senior faculty, whose research is consistent with this underlying scientific theme and the overall goals of our Center. The underlying hypothesis that ties these investigators together is that targeting diverse microbial pathogens in the context of their impact on immunological and inflammatory responses in their common human host will optimize opportunities for the elucidation of common themes with respect to the host response and its adverse consequences on the disease process. To this end, this application brings together as Project Leaders four investigators who focus on diverse microbial pathogens from the point of view of both the pathogens themselves and their impact on host inflammatory responses. To support these investigators, and to build a pipeline of new investigators whose research is consistent with our underlying scientific theme, we propose to provide an integrated and highly interactive faculty development plan for all Center investigators that leverages the resources developed during Phase I to enable our Phase II Project Leaders and other Center investigators to establish independently-funded research careers in an area consistent with this underlying theme (Aim 1); to utilize the Administrative and Scientific Development (Core A) and Research and Technical Advancement (Core B) cores developed during Phase I to continue to promote the scientific development of Center investigators and enhance the overall research infrastructure on the host campuses (Aim 2); and to build on the success of our Phase I efforts to recruit additional investigators whose research is consistent with the underlying scientific theme and promote the development of collaborative, synergistic research relationships among Center investigators (Aim 3). This will allow us to build on the success of Phase I Project Leaders to establish a self-sustaining Center for Microbial Pathogenesis and Host Inflammatory Responses.