Integrated Physiology Training: Molecule to Organism

综合生理学培训：分子到有机体

• 批准号: 10222748
• 负责人: Matthew Robert Hodges
• 金额: $ 29.97万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222748
• 关键词: Organism; Physiology; Training

PROJECT SUMMARY Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that creates a challenge for students seeking an understanding of the discipline at the whole animal to the cellular and molecular levels. One exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers exceptional research training emphasizing the integration of knowledge at all of these levels, and the relationship of this knowledge to human disease processes. In our current proposal, we will continue providing this outstanding training in cellular, molecular, and whole animal Physiology for 6 NIH- supported trainees each year. In addition, we request funds to provide stipends for 6 rising 2nd year medical students enrolled at MCW to spend 11 weeks during the summer engaged in research in the laboratory of one of our faculty to enhance recruitment of medical students into biomedical research. Unique aspects of the proposed PhD training are the multidisciplinary mentoring program and opportunities for translational research fostered by a highly collaborative basic science and clinical faculty. Graduate students will be recruited nationally and selected for admission on the basis of undergraduate academic credentials, previous research experience, and commitment to a career in research. Students must successfully complete the requirements of the first two years of graduate school before being considered for T32 support. Selection of T32 trainees will be based on performance in course work, the preliminary examination and in research. Trainees are full-time Ph.D. candidates in the MCW Graduate School, and will complete a research that includes use of the techniques in molecular, cellular, tissue, and whole-animal or clinical investigation. Research training is supervised by Physiology faculty along with co-mentors from other basic science and clinical departments. Trainees will undergo continuous evaluation by utilizing Individual Development Plans created upon matriculation, which are reviewed and updated yearly. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research through developing critical thinking, integrative reasoning, and technical skills required to succeed in evolving research careers focused on the prevention of hypertension, stroke, and respiratory diseases. An innovative feature of the training is the emphasis on addressing the national need to train for the integrated- systems approaches that represent the future of biomedical research in the post-genomic era. The success of our program in research is indicated by the 47 first-authored publications from 24 T32 supported graduates over the past 10 years (Table 5A), and their contribution to 51 manuscripts coauthored with other students or faculty, indicative of our highly collaborative training program. Another measure of overall success of our program is that 94% of T32 trainees who completed our program over the past 15 years (Table 8A) have continued in a biomedical field, with 18 obtaining research, teaching, and/or patient care faculty positions and only two trainees withdrew from the program without obtaining the PhD (average duration of training was 4.96 years).

项目总结 在过去的二十年里，全国各地生理学部门的培训经历了 为寻求对整个动物的学科理解的学生带来挑战的转变 到细胞和分子水平。其中一个例外是麻省理工学院生理学系。 威斯康星州(MCW)，它提供特别的研究培训，强调在所有 这些水平，以及这些知识与人类疾病过程的关系。在我们目前的提案中，我们将 继续为6个NIH提供细胞、分子和整个动物生理学方面的出色培训- 每年资助受训人员。此外，我们要求提供资金，以提供6个上升的第二年的医疗津贴 在MCW注册的学生在暑假期间花11周的时间在One的实验室进行研究 加强生物医学研究专业的医学生招生工作。独一无二的方面 拟议的博士培训是多学科指导计划和翻译研究的机会 由高度合作的基础科学和临床教职员工培养。研究生将面向全国招生 并根据本科生学历，以前的研究经验， 以及致力于研究事业。学生必须成功完成前两项要求 在被考虑支持T32之前，他已经读了几年的研究生。T32实习生的遴选将基于 在课程作业、初试和研究方面的表现。实习生为全日制博士候选人 ，并将完成一项研究，其中包括在分子中使用技术， 细胞、组织和全动物或临床研究。研究训练由生理学教师指导。 以及来自其他基础科学和临床科室的共同导师。学员将接受连续的 通过利用在入学时创建的个人发展计划进行评估，这些计划经过审查和更新 每年一次。主要目标是为学员提供跨学科的基础科学和 通过发展批判性思维、综合推理和所需的技术技能进行翻译研究 成功地发展了专注于高血压、中风和呼吸系统疾病预防的研究事业。 培训的一个创新特点是强调满足国家对综合培训的需求- 代表后基因组时代生物医学研究未来的系统方法。的成功之处 我们的研究计划是由来自24个T32资助的毕业生的47个第一作者出版的 过去10年(表5A)，以及他们对51篇与其他学生或教师合著的手稿的贡献， 表明我们高度合作的培训计划。衡量我们项目总体成功的另一个标准是 在过去15年内完成我们计划的T32学员中有94%(表8A)继续在 生物医学领域，18人获得研究、教学和/或患者护理学院职位，只有两名实习生 在没有获得博士学位的情况下退出该计划(平均培训时间为4.96年)。