INTEGRATED PHYSIOLOGY TRAINING-- MOLECULE TO ORGANISM

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EXCEED THE SPACE PROVIDED. During the last ten to fifteen years, training in Physiology departments in this country has undergone a tranformation that precludes students from obtaining researchtraining that spans the discipline from the whole animal to the cellular and molecular level. An exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers researchtraining emphasizing integration of knowledge at all these evels as well as development of an appreciation for the relationship of this knowledge to disease processes. ndeed, in the past 5 years, 19 students (2 NIH trainees) have received their Ph.D. from this department and are now successful in additional training or as faculty members. This proposed program will continue to provide training in Cellular, Molecular, and Whole Animal Physiology. Trainees will be recruited nationally and will be selected on the basis of academic credentials, previous research experience, and commitment to a career in research and training. Trainees will complete required and elective courses and a research project that includes use of the techniques of molecular biology, biochemistry, isolated tissues, and whole animal investigation. Emphasis will be placed on interpretation of the relationship of data obtained from subcellular systems to normal and abnormal physiology of the whole animal. Research will be in the areas of hypertension, stroke, and pulmonary disease, and will be designed to provide trained biomedical scientists in those areas of need, each of which has been targeted by theNIH. Research training will be conducted under the direct supervision of the primary faculty of the training program (faculty of the Department of Physiology) who have extensive experience in training Graduate tudents and have productive NIH funded research programs. Secondary faculty will serve on dissertation committees contributing their special expertise. All trainees will be full-time Ph.D. candidates in the MCW GraduateSchool. Trainee progress in developing critical, integrative thought and in acquiring the skills required to successfully contribute to continuing studies on prevention and control of cardiovascularand pulmonary disease will be monitored at regular intervals. PERFORMANCE SITE ========================================Section End===========================================