Integrated Physiology Training: Molecule to Organism

描述(由申请者提供)：在过去的二十年里，全国生理学系的培训经历了一场变革，使学生无法彻底理解从整个动物到细胞和分子水平的学科广度。威斯康星医学院(MCW)生理学系是一个例外，该系提供研究培训，强调整合所有这些级别的知识，并培养对这些知识与疾病过程的关系的认识。根据目前的建议，我们将继续为每年6名NIH支持的学员提供细胞、分子和整个动物生理学方面的特殊培训。拟议中的培训的一个独特方面是指导计划，其中包括来自各种传统领域的基础科学家以及临床科学家。研究生将在全国范围内招生，并根据本科生的学历、研究经验和对研究和培训事业的承诺来选择。学生完成第一年的研究生院之前，他们将被考虑为国家卫生研究院的培训支持。培训生的选择将主要根据研究生院第一年的课程工作和研究实验室的表现。实习生是麻省理工学院生物医学研究生院的全日制博士候选人。他们将完成必修课和选修课，以及一个研究项目，其中包括使用分子生物学、分离组织和整个动物或临床研究的技术。主要目标是为学员提供跨学科基础科学和翻译研究的广泛基础，如第147页所述。学员将发展批判性思维、综合推理和技术技能，以创造和参与与高血压、中风和呼吸系统疾病预防和控制相关的不断发展的研究事业。一个创新的特点是强调满足国家需要，为后基因组时代生物医学研究的更综合系统的未来进行培训。研究训练由初级生理学教员以及其他基础科学和临床教员的共同导师监督。该计划将培训生物医学科学家进行研究和教育医疗专业人员，从而发现和交流预防和管理心血管和肺部疾病所需的信息。

Description (provided by applicant): Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that precludes students from a thorough understanding that spans the breadth of the discipline from the whole animal to the cellular and molecular level. An exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers research training emphasizing integration of knowledge at all these levels with development of an appreciation for the relationship of this knowledge to disease processes. With the current proposal, we will continue providing this exceptional training in cellular, molecular, and whole animal physiology for 6 NIH supported trainees each year. A unique aspect of the proposed training is the mentoring program, which includes basic scientists from a variety of traditional areas as well as clinican scientists. Graduate students will be recruited nationally and selected on the basis of undergraduate academic credentials, research experience, and commitment to a career in research and training. Students complete the first year of graduate school before they will be considered for NIH training support. Selection of trainees will be based primarily on performance in course work and in the research laboratory during the first year of graduate school. Trainees are full-time Ph.D. candidates in the MCW graduate school of biomedical sciences. They will complete required and elective courses and a research project that includes use of the techniques of molecular biology, isolated tissues, and whole animal or clinical investigation. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research as outlined on page 147. Trainees will develop the critical thinking, integrative reasoning, and technical skills required to create and participate in evolving research careers related to prevention and control of hypertension, stroke, and respiratory diseases. An innovative feature is the emphasis on addressing the national need to train for the more integrated-systems future of biomedical research in the post-genome era. Research training is supervised by primary Physiology faculty along with co-mentors from other basic science and clinical faculty. The program will train biomedical scientists to conduct research and educate medical professionals leading to the discovery and communication of information required for the prevention and management of cardiovascular and pulmonary disease.