Integrated Physiology Training: Molecule to Organism

综合生理学培训：分子到有机体

• 批准号: 10439685
• 负责人: Matthew Robert Hodges
• 金额: $ 18.43万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10439685
• 关键词: Organism; Physiology; Training

PROJECT SUMMARY Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that creates a challenge for students seeking an understanding of the discipline at the whole animal to the cellular and molecular levels. One exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers exceptional research training emphasizing the integration of knowledge at all of these levels, and the relationship of this knowledge to human disease processes. In our current proposal, we will continue providing this outstanding training in cellular, molecular, and whole animal Physiology for 6 NIH- supported trainees each year. In addition, we request funds to provide stipends for 6 rising 2nd year medical students enrolled at MCW to spend 11 weeks during the summer engaged in research in the laboratory of one of our faculty to enhance recruitment of medical students into biomedical research. Unique aspects of the proposed PhD training are the multidisciplinary mentoring program and opportunities for translational research fostered by a highly collaborative basic science and clinical faculty. Graduate students will be recruited nationally and selected for admission on the basis of undergraduate academic credentials, previous research experience, and commitment to a career in research. Students must successfully complete the requirements of the first two years of graduate school before being considered for T32 support. Selection of T32 trainees will be based on performance in course work, the preliminary examination and in research. Trainees are full-time Ph.D. candidates in the MCW Graduate School, and will complete a research that includes use of the techniques in molecular, cellular, tissue, and whole-animal or clinical investigation. Research training is supervised by Physiology faculty along with co-mentors from other basic science and clinical departments. Trainees will undergo continuous evaluation by utilizing Individual Development Plans created upon matriculation, which are reviewed and updated yearly. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research through developing critical thinking, integrative reasoning, and technical skills required to succeed in evolving research careers focused on the prevention of hypertension, stroke, and respiratory diseases. An innovative feature of the training is the emphasis on addressing the national need to train for the integrated- systems approaches that represent the future of biomedical research in the post-genomic era. The success of our program in research is indicated by the 47 first-authored publications from 24 T32 supported graduates over the past 10 years (Table 5A), and their contribution to 51 manuscripts coauthored with other students or faculty, indicative of our highly collaborative training program. Another measure of overall success of our program is that 94% of T32 trainees who completed our program over the past 15 years (Table 8A) have continued in a biomedical field, with 18 obtaining research, teaching, and/or patient care faculty positions and only two trainees withdrew from the program without obtaining the PhD (average duration of training was 4.96 years).

项目概要 近二十年来，全国生理科室的培训经历了突飞猛进的发展。 转变为寻求了解整个动物学科的学生带来了挑战 到细胞和分子水平。一个例外是医学院生理学系 威斯康星州 (MCW)，提供卓越的研究培训，强调所有领域的知识整合 这些水平，以及这些知识与人类疾病过程的关系。在我们当前的提案中，我们将 继续为 6 名 NIH- 提供细胞、分子和整个动物生理学方面的杰出培训 每年都支持实习生。此外，我们请求资金为 6 名升入第二年的医疗人员提供津贴 MCW 注册的学生将在暑假期间在实验室进行 11 周的研究 我们的教师队伍，以加强招募医学生进行生物医学研究。独特的方面 拟议的博士培训包括多学科指导计划和转化研究机会 由高度协作的基础科学和临床教师培育。面向全国招生研究生 并根据本科学历、以往的研究经验选择录取， 以及对研究事业的承诺。学生必须成功完成前两项的要求 在考虑获得 T32 支持之前，已经读了多年的研究生院。 T32学员的选拔将基于 课程作业、初步考试和研究中的表现。受训人员均为全日制博士生。候选人 在 MCW 研究生院，并将完成一项研究，包括使用分子技术、 细胞、组织和整个动物或临床研究。研究培训由生理学教师监督 以及来自其他基础科学和临床部门的共同导师。学员将持续接受 利用入学时制定的个人发展计划进行评估，并对其进行审查和更新 每年。主要目标是为学员提供跨学科基础科学和知识的广泛基础 通过培养批判性思维、综合推理和技术技能来进行转化研究 成功发展专注于预防高血压、中风和呼吸系统疾病的研究事业。 此次培训的一个创新特点是强调满足国家综合培训需求。 代表后基因组时代生物医学研究未来的系统方法。的成功 我们的研究计划由 24 名 T32 资助的毕业生发表的 47 篇第一作者出版物表明 过去 10 年（表 5A），以及他们与其他学生或教师合着的 51 篇手稿的贡献， 这体现了我们高度协作的培训计划。衡量我们计划总体成功的另一个标准是 在过去 15 年里完成我们项目的 T32 学员中，94%（表 8A）继续在 生物医学领域，有 18 人获得研究、教学和/或患者护理教职，只有 2 名实习生 未获得博士学位就退出该项目（平均培训时间为4.96年）。