Integrated Physiology Training: Molecule to Organism

综合生理学培训：分子到有机体

• 批准号: 10439685
• 负责人: Matthew Robert Hodges
• 金额: $ 18.43万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10439685
• 关键词: Organism; Physiology; Training

PROJECT SUMMARY Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that creates a challenge for students seeking an understanding of the discipline at the whole animal to the cellular and molecular levels. One exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers exceptional research training emphasizing the integration of knowledge at all of these levels, and the relationship of this knowledge to human disease processes. In our current proposal, we will continue providing this outstanding training in cellular, molecular, and whole animal Physiology for 6 NIH- supported trainees each year. In addition, we request funds to provide stipends for 6 rising 2nd year medical students enrolled at MCW to spend 11 weeks during the summer engaged in research in the laboratory of one of our faculty to enhance recruitment of medical students into biomedical research. Unique aspects of the proposed PhD training are the multidisciplinary mentoring program and opportunities for translational research fostered by a highly collaborative basic science and clinical faculty. Graduate students will be recruited nationally and selected for admission on the basis of undergraduate academic credentials, previous research experience, and commitment to a career in research. Students must successfully complete the requirements of the first two years of graduate school before being considered for T32 support. Selection of T32 trainees will be based on performance in course work, the preliminary examination and in research. Trainees are full-time Ph.D. candidates in the MCW Graduate School, and will complete a research that includes use of the techniques in molecular, cellular, tissue, and whole-animal or clinical investigation. Research training is supervised by Physiology faculty along with co-mentors from other basic science and clinical departments. Trainees will undergo continuous evaluation by utilizing Individual Development Plans created upon matriculation, which are reviewed and updated yearly. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research through developing critical thinking, integrative reasoning, and technical skills required to succeed in evolving research careers focused on the prevention of hypertension, stroke, and respiratory diseases. An innovative feature of the training is the emphasis on addressing the national need to train for the integrated- systems approaches that represent the future of biomedical research in the post-genomic era. The success of our program in research is indicated by the 47 first-authored publications from 24 T32 supported graduates over the past 10 years (Table 5A), and their contribution to 51 manuscripts coauthored with other students or faculty, indicative of our highly collaborative training program. Another measure of overall success of our program is that 94% of T32 trainees who completed our program over the past 15 years (Table 8A) have continued in a biomedical field, with 18 obtaining research, teaching, and/or patient care faculty positions and only two trainees withdrew from the program without obtaining the PhD (average duration of training was 4.96 years).

项目摘要 在过去的二十年里，全国各地的生理学部门的培训经历了一个 转变，为学生创造了一个挑战，寻求在整个动物学科的理解 到细胞和分子水平。其中一个例外是纽约医学院的生理学系。 威斯康星州（MCW），提供卓越的研究培训，强调在所有的知识整合， 这些水平，以及这些知识与人类疾病过程的关系。在我们目前的提案中，我们将 继续提供细胞，分子和整个动物生理学的优秀培训，为6 NIH- 每年都有学员参加。此外，我们要求资金为6名第二年的医疗费用提供津贴。 在MCW注册的学生在夏天花11周的时间在一个实验室从事研究 我们的教师，以加强招聘医学生进入生物医学研究。独特的方面 建议的博士培训是多学科的指导计划和转化研究的机会 由高度协作的基础科学和临床教师培养。研究生将面向全国招生 并根据本科学历，以前的研究经验， 致力于研究事业学生必须成功完成前两项要求 在被考虑支持T32之前，我已经在研究生院工作了几年。T32学员的选择将基于 在课程工作、初审和研究中的表现。实习生为全日制博士。候选人 在MCW研究生院，并将完成一项研究，其中包括使用分子技术， 细胞、组织和整体动物或临床研究。研究培训由生理学教师监督 沿着来自其他基础科学和临床部门的共同导师。学员将接受连续的 利用入学时制定的个人发展计划进行评估，并对其进行审查和更新 每年一次。主要目标是为学员提供跨学科基础科学的广泛基础， 翻译研究通过发展批判性思维，综合推理和所需的技术技能， 成功地发展研究事业，重点是预防高血压，中风和呼吸系统疾病。 培训的一个创新特点是强调满足国家对培训综合能力的需要， 系统方法，代表了后基因组时代生物医学研究的未来。的成功 我们的研究计划由24名T32支持的毕业生的47篇第一作者的出版物表明， 过去10年（表5A），以及他们与其他学生或教师合著的51篇手稿的贡献， 这表明了我们高度合作的培训项目衡量我们项目整体成功的另一个标准是， 在过去15年中完成我们计划的T32学员中，有94%（表8A）继续参加 生物医学领域，18人获得研究，教学和/或病人护理教师职位，只有两名受训人员 没有获得博士学位就退出了该项目（平均培训时间为4.96年）。